全文获取类型
收费全文 | 4770篇 |
免费 | 188篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 157篇 |
妇产科学 | 177篇 |
基础医学 | 594篇 |
口腔科学 | 195篇 |
临床医学 | 397篇 |
内科学 | 1056篇 |
皮肤病学 | 60篇 |
神经病学 | 413篇 |
特种医学 | 195篇 |
外科学 | 610篇 |
综合类 | 22篇 |
一般理论 | 2篇 |
预防医学 | 224篇 |
眼科学 | 22篇 |
药学 | 266篇 |
中国医学 | 6篇 |
肿瘤学 | 534篇 |
出版年
2023年 | 12篇 |
2022年 | 58篇 |
2021年 | 110篇 |
2020年 | 51篇 |
2019年 | 92篇 |
2018年 | 121篇 |
2017年 | 68篇 |
2016年 | 64篇 |
2015年 | 75篇 |
2014年 | 103篇 |
2013年 | 164篇 |
2012年 | 255篇 |
2011年 | 247篇 |
2010年 | 131篇 |
2009年 | 108篇 |
2008年 | 236篇 |
2007年 | 223篇 |
2006年 | 209篇 |
2005年 | 234篇 |
2004年 | 223篇 |
2003年 | 247篇 |
2002年 | 184篇 |
2001年 | 171篇 |
2000年 | 208篇 |
1999年 | 159篇 |
1998年 | 71篇 |
1997年 | 47篇 |
1996年 | 37篇 |
1995年 | 35篇 |
1994年 | 35篇 |
1993年 | 28篇 |
1992年 | 85篇 |
1991年 | 98篇 |
1990年 | 82篇 |
1989年 | 76篇 |
1988年 | 67篇 |
1987年 | 77篇 |
1986年 | 71篇 |
1985年 | 63篇 |
1984年 | 47篇 |
1983年 | 45篇 |
1982年 | 18篇 |
1981年 | 22篇 |
1980年 | 14篇 |
1979年 | 37篇 |
1978年 | 23篇 |
1975年 | 17篇 |
1974年 | 14篇 |
1973年 | 14篇 |
1966年 | 14篇 |
排序方式: 共有4969条查询结果,搜索用时 0 毫秒
111.
112.
J A Manfredi R P Wall D C Sane G A Braden 《Catheterization and cardiovascular interventions》2001,52(4):468-472
Heparin-induced thrombocytopenia (HIT) is a well-documented complication of heparin anticoagulation therapy. Heparin's frequent use in the cardiovascular population poses a significant challenge for managing patients with HIT in need of percutaneous coronary intervention (PCI). We describe four patients with HIT who successfully underwent PCI without thrombotic or hemorrhagic complications while on lepirudin. 相似文献
113.
Summary Two hundreds and sixty red foxes, eighteen badgers and eight stone martens from north-eastern Italy were examined for zoonotic
parasites by SCT, with particular attention to Trichinella sp. and Echinococcus multilocularis. No adult worms of E. multilocularis were observed in the intestine of red foxes or mustelids. Out of 223 fox faecal samples analysed by a commercial CA-ELISA,
5.8 % was positive to Echinococcus coproantigens. Trichinella sp. was detected by digestion of muscle in 1.2 % of examined foxes (2/172), but not in mustelids (0/11). Toxocara canis, responsible for human toxocarosis, resulted to be common in fox population (48.5 %). This parasite was found both in young
(53.3 % of cubs and 61.9 % of sub-adults) and in adult animals (42.7 %). Other zoonotic parasites as Uncinaria stenocephala (52.3 %) and Trichuris vulpis (0.4 %) were detected in fox populations. 相似文献
114.
Inflammatory carcinoma of the breast. Clinical review and summary of the Vanderbilt experience with multi-modality therapy 总被引:1,自引:0,他引:1
M M Sherry D H Johnson D L Page F A Greco J D Hainsworth 《The American journal of medicine》1985,79(3):355-364
Inflammatory breast cancer is a distinct clinicopathologic entity that accounts for 1 percent of all cases of breast cancer. The diagnosis should be strongly suspected on the basis of the distinctive clinical findings, which include edema of the breast, inflammation, wheals, and a typical reddish-purple color of the overlying skin. Pathologic examination usually shows infiltration of the dermal lymphatics with carcinoma. Evidence of distant metastatic spread is more frequent than with other types of breast cancer and is seen in approximately 30 percent of patients. The five-year disease-free survival rate is less than 5 percent when local therapy alone (mastectomy and/or local radiotherapy) is used. The addition of combination chemotherapy to high-dose local radiotherapy has improved the five-year survival rate to approximately 30 percent. The potential for long-term survival is limited to the subgroup of patients with only local-regional disease at the time of diagnosis. Patients with inflammatory breast cancer should be treated with combined-modality therapy using combination chemotherapy and high-dose radiotherapy to the breast, since this approach is potentially curative. The fatalism formerly associated with this diagnosis is no longer warranted, particularly in patients with local-regional disease. Failure to employ intensive combined-modality treatment will deny some patients a chance for long-term survival. 相似文献
115.
Lethal cancer and chronic untreatable viral disease with life threatening consequences are among the major burden for morbidity and mortality in the western world. A large number of resources are employed every year in identification of new drugs to treat this condition. A remarkable percentage of resources are wasted for safety concerns about possible acute cardiac or pulmonary toxicity of the new identified compounds, that are rejected without further development even when promising. ExtraCorporeal Membrane Oxygenation (ECMO) is an established technique to support and replace cardio-pulmonary function that underwent rapid technologic improvement in the last years, resulting in reduced complication rate. ECMO has been used with success to treat acute life-threatening cardiac and pulmonary toxicity. Our hypothesis is that the new ECMO technological improvement could make this technique available to other setting, such as lethal cancer and infectious diseases, where it can provide a safe base to overwhelm acute cardiac and pulmonary toxicity of chemotoxic drugs and techniques. New drugs and old promising compounds rejected for toxicity could thus be re-introduced and employed, opening a new scenario in the treatment of life-threatening diseases. 相似文献
116.
Viviana Lo Buono Rosanna Palmeri Simona De Salvo Matteo Berenati Agata Greco Rosella Ciurleo Chiara Sorbera Vincenzo Cimino Francesco Corallo Placido Bramanti Silvia Marino Giuseppe Di Lorenzo Lilla Bonanno 《中国神经再生研究》2021,16(3):587
Anxiety and depression in Parkinson’s disease (PD) reduce well-being of the patients. Emotional alterations influence motor skills and cognitive performance; moreover, they contribute significantly and independently to worsen rehabilitative treatment response. We investigated anxiety, depression, and quality of life in PD patients subjected to multidisciplinary rehabilitative training. The self-controlled study included 100 PD patients (49 males and 51 females with the mean age of 64.66 years) admitted to 60 days hospitalization rehabilitative program, between January 2017 and December 2018. Motor, cognitive, linguistic abilities, and functional independence were evaluated at admission (T0 baseline visit) and 60 days after (T1) the multidisciplinary rehabilitation including motor exercises, speech therapies, and cognitive intervention. The multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood, motor abilities, autonomy in the activities of daily life, perception of quality of life, cognitive performance and speech skills. Non-motor symptoms may worsen severe disability and reduce quality of life. They are often poorly recognized and inadequately treated. Nonetheless, multidisciplinary rehabilitative training represents an optimal strategy to improve disease management. The study was approved by Istituito di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi “Bonino-Pulejo” Ethical Committee (approval No. 6/2016) in June 2016. 相似文献
117.
Francesco Manfredi Danilo Abbati Beatrice Claudia Cianciotti Lorena Stasi Alessia Potenza Eliana Ruggiero Zulma Magnani Erica Carnevale Matteo Doglio Maddalena Noviello Elena Tassi Chiara Balestrieri Silvia Buonanno Francesca Clemente Claudia De Lalla Maria Pia Protti Anna Mondino Giulia Casorati Paolo Dellabona Chiara Bonini 《European journal of immunology》2021,51(8):1992-2005
The phenotype of infused cells is a major determinant of Adoptive T-cell therapy (ACT) efficacy. Yet, the difficulty in deciphering multiparametric cytometry data limited the fine characterization of cellular products. To allow the analysis of dynamic and complex flow cytometry samples, we developed cytoChain, a novel dataset mining tool and a new analytical workflow. CytoChain was challenged to compare state-of-the-art and innovative culture conditions to generate stem-like memory cells (TSCM) suitable for ACT. Noticeably, the combination of IL-7/15 and superoxides scavenging sustained the emergence of a previously unidentified nonexhausted Fit-TSCM signature, overlooked by manual gating and endowed with superior expansion potential. CytoChain proficiently traced back this population in independent datasets, and in T-cell receptor engineered lymphocytes. CytoChain flexibility and function were then further validated on a published dataset from circulating T cells in COVID-19 patients. Collectively, our results support the use of cytoChain to identify novel, functionally critical immunophenotypes for ACT and patients immunomonitoring. 相似文献
118.
Rossella Rella Andrea Contegiacomo Enida Bufi Sara Mercogliano Paolo Belli Riccardo Manfredi 《The British journal of radiology》2021,94(1119)
Objectives:To conduct a systematic review of evidences about the relationship between background parenchymal enhancement (BPE) of the contralateral healthy breast and breast cancer: its association with clinicopathological breast cancer characteristics, its potential as predictive and prognostic biomarker and the biological linkage between BPE and breast cancer.Methods:A computerized literature search using PubMed and Google Scholar was performed up to June 2020. Two authors independently conducted search, screening, quality assessment, and extraction of data from the eligible studies. Studies were assessed for quality and risk of bias using the revised Quality Assessment of Diagnostic Accuracy Studies tool.Results:Of the 476 articles identified, 22 articles met the inclusion criteria. No significant association was found between BPE and invasiveness, histological cancer type, T- and N-stage, multifocality, lymphatic and vascular invasion and histological tumour grade while the association between BPE and molecular subtypes is still unclear. As predictive biomarker, a greater decrease in BPE during and after neoadjuvant chemotherapy was associated with pathological complete response. Results about the role of BPE as prognostic factor were inconsistent. An association between high BPE and microvessel density, CD34 and VEGF (histological markers of vascularization and angiogenesis) was found.Conclusions:BPE of the contralateral breast is associated with breast cancer in several aspects, therefore it has been proposed as a tool to refine breast cancer decision-making process.Advances in knowledge:Additional researches with standardized BPE assessment are needed to translate this emerging biomarker into clinical practice in the era of personalized medicine. 相似文献
119.