全文获取类型
收费全文 | 21983篇 |
免费 | 1017篇 |
国内免费 | 166篇 |
专业分类
耳鼻咽喉 | 208篇 |
儿科学 | 450篇 |
妇产科学 | 179篇 |
基础医学 | 2927篇 |
口腔科学 | 490篇 |
临床医学 | 1407篇 |
内科学 | 5688篇 |
皮肤病学 | 499篇 |
神经病学 | 1773篇 |
特种医学 | 762篇 |
外科学 | 3646篇 |
综合类 | 59篇 |
一般理论 | 4篇 |
预防医学 | 554篇 |
眼科学 | 659篇 |
药学 | 1472篇 |
中国医学 | 32篇 |
肿瘤学 | 2357篇 |
出版年
2023年 | 136篇 |
2022年 | 308篇 |
2021年 | 539篇 |
2020年 | 256篇 |
2019年 | 333篇 |
2018年 | 434篇 |
2017年 | 348篇 |
2016年 | 459篇 |
2015年 | 506篇 |
2014年 | 612篇 |
2013年 | 737篇 |
2012年 | 1259篇 |
2011年 | 1355篇 |
2010年 | 802篇 |
2009年 | 702篇 |
2008年 | 1205篇 |
2007年 | 1362篇 |
2006年 | 1284篇 |
2005年 | 1416篇 |
2004年 | 1418篇 |
2003年 | 1273篇 |
2002年 | 1290篇 |
2001年 | 394篇 |
2000年 | 328篇 |
1999年 | 409篇 |
1998年 | 342篇 |
1997年 | 261篇 |
1996年 | 263篇 |
1995年 | 229篇 |
1994年 | 200篇 |
1993年 | 219篇 |
1992年 | 237篇 |
1991年 | 195篇 |
1990年 | 214篇 |
1989年 | 201篇 |
1988年 | 165篇 |
1987年 | 127篇 |
1986年 | 144篇 |
1985年 | 137篇 |
1984年 | 111篇 |
1983年 | 93篇 |
1982年 | 72篇 |
1981年 | 63篇 |
1980年 | 52篇 |
1979年 | 81篇 |
1978年 | 68篇 |
1974年 | 44篇 |
1973年 | 52篇 |
1967年 | 42篇 |
1966年 | 43篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
31.
Yoshihiro Wakayama Masahiko Inoue Makoto Murahashi Seiji Shibuya Takahiro Jimi Hiroko Kojima Hiroaki Oniki 《Annals of neurology》1996,39(2):217-223
The ultrastructural localization of adhalin and its relations to dystrophin, β-dystroglycan, and β-spectrin were studied in normal murine skeletal myofibers. The C-terminal peptides of adhalin and β-dystroglycan were synthesized based on their cDNAs, and the affinity-purified antibodies against these peptides were produced. Single-immunolabeling electron microscopy showed that the adhalin was located just inside the muscle plasma membrane or inside the myofiber a short distance from the plasma membrane. The adhalin signal was also noted at the sarcoplasmic side of plasmalemmd invaginations or at vesicular structures in subsarcolemmal areas. Double-immunogold-labeling electron microscopy disclosed a similar localization of dystrophin, β-dystroglycan, and β-spectrin. The close association of adhalin with dystrophin or β-dystroglycan was demonstrated by formation of doublets by signals of antibodies of adhalin with those of dystrophin or β-dystroglycan and was confirmed by statistical analyses. This study demonstrated that the location of adhalin is close to that of dystrophin and β-dystroglycan at the muscle plasma membrane. 相似文献
32.
33.
34.
Yoshito Tomimaru Ken Kodama Jiro Okami Kazuyuki Oda Koji Takami Masahiko Higashiyama 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(5):193-198
Objective Postoperative pericardial effusion commonly occurs after open heart surgery. However, after general thoracotomy such as pulmonary
resection, there have been few reports of pericardial effusion. The purpose of this study is to investigate patients with
pericardial effusion following pulmonary resection.Methods: Among 2,385 patients with pulmonary resection for lung neoplasm in our institute, eight patients, whose pericardium had
never been opened during the operation, developed pericardial effusion. The clinical characteristics of the eight patients
were analyzed.Results: Pericardial effusion after pulmonary resection was divided into two subtypes: pericardial effusion in three patients with
left thoracotomy occurring within 30 days postoperatively, and pericardial effusion in the remaining five patients with right
thoracotomy occurring more than 30 days postoperatively. Pericardiotomy or pericardiocentesis was performed in three symptomatic
patients, and the remaining five asymptomatic patients were treated with diuretics. Pericardial effusion disappeared in three
of the five patients about 1–3 months after the conservative treatment, while, in the remaining patients, because pericardial
effusion had increased gradually, pericardiocentesis was performed.Conclusion: From our experience, the treatment strategy of drainage for early pericardial effusion and diuretics for late pericardial
effusion seems to be appropriate. (Jpn J Thorac Cardiovasc Surg 2006; 54:193-198) 相似文献
35.
36.
37.
Toshihiko Imakiire Yuichi Kikuchi Muneharu Yamada Taketoshi Kushiyama Keishi Higashi Naomi Hyodo Kojiro Yamamoto Takashi Oda Shigenobu Suzuki Soichiro Miura 《Hypertension research》2007,30(7):635-642
The mechanisms of hypertensive nephrosclerosis are not fully understood. In experimental models of the disease, inflammatory reactions such as macrophage infiltration play an important role. In human hypertensive nephrosclerosis, however, there have been few studies examining the role of inflammation histologically. We investigated whether the number of infiltrating macrophages was increased in human hypertensive nephrosclerosis, and evaluated the effects of a blockade of the renin-angiotensin system on clinical and histological findings. We examined macrophage infiltration using immunohistochemistry in renal biopsy specimens obtained from 16 patients with hypertensive nephrosclerosis, 5 patients with IgA nephropathy, 5 patients with membranous nephropathy, and 5 patients with minimal change nephrotic syndrome. The number of infiltrating macrophages in glomeruli was significantly larger in the patients with hypertensive nephrosclerosis than in those with minimal change nephrotic syndrome. The patients with hypertensive nephrosclerosis were divided into groups based on their use of antihypertensive agents at the time of renal biopsy. We investigated the effects of antihypertensive agents on clinical findings, macrophage infiltration, and monocyte chemoattractant protein-1 expression. There was no difference in clinical findings between the hypertensive groups. The numbers of infiltrating macrophages and monocyte chemoattractant protein-1-positive cells in glomeruli were significantly smaller in patients treated with an angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor blocker, whereas calcium channel blockers had no influence on histological findings. In conclusion, inflammation is involved in the progression of human hypertensive nephrosclerosis and the inflammatory process is inhibited by blocking the renin-angiotensin system. 相似文献
38.
Seijiro Yoshida Yoshio Nitta Katsuhiko Oda 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(4):230-233
A 65-year-old patient with ischemic heart disease and severe diabetes mellitus underwent minimally invasive direct coronary
artery bypass grafting under general combined with epidural anesthesia. Paraplegia developed after surgery and the diagnosis
of anterior spinal artery syndrome was made based on the patient s neurological condition and magnetic resonance imaging findings.
Paraplegia following epidural anesthesia is a rare but recognized complication and this complication should be taken into
account, especially in patients at risk, when considering epidural analgesia techniques in the minimally invasive cardiac
surgery. 相似文献
39.
D Craig Willcox Bradley J Willcox Sanae Shimajiri Sayuri Kurechi Makoto Suzuki 《The American journal of geriatric psychiatry》2007,15(3):252-256
OBJECTIVE: This study retrospectively explored the late-life functional status of Okinawan centenarians. METHODS: Activities of daily living were measured retrospectively at five time points (10, 5, 3, and 1 year prior and present) for 22 centenarians in relation to seven physical, two sensory, and two cognitive functions using the Inoue Index. RESULTS: In all, 82% of individuals were still functioning independently at a mean age of 92 years and almost two-thirds were still functioning independently at a mean age of 97 years. CONCLUSION: Preliminary analyses suggest high functional status in Okinawan centenarians throughout their 90 s. The genetic and environmental factors contributing to this successful aging phenomenon deserve further investigation. 相似文献
40.
Hiromi Kataoka Takashi Joh Yusuke Inoue Naotaka Ogasawara Tadayuki Oshima Satoshi Tanida Makoto Sasaki Haruhisa Nakao Takahiro Nakazawa Hirotaka Ohara 《Digestive endoscopy》2006,18(4):294-297
A 75‐year‐old male was admitted to the gastroenterology unit of Nagoya City University Hospital due to epigastralgia after surgical treatment for right renal cancer. Endoscopy revealed advanced type 1 gastric cancer in the corpus of the stomach and multiple polypoid lesions in the stomach and duodenum. X‐ray examination of the small intestine using barium showed multiple polyps in the upper jejunum. Faint pigmentation on the palm was also detected. Peutz‐Jeghers syndrome (PJS) was diagnosed, despite a lack of family history. Total gastrectomy, resection of part of the upper jejunum and intraoperative endoscopic polypectomy of duodenal polyps was performed. This is the second reported case of PJS associated with renal cancer. We also detected a missense mutation in the tumor suppressor gene STK11 that, when mutated, is causative for PJS. 相似文献