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排序方式: 共有8743条查询结果,搜索用时 15 毫秒
41.
Stamborowski Sadi Fernando de Oliveira Spinelli Bruna Moreira Lima Fernanda Pupio Silva Costa Davidson Ribeiro de Silveira Souza Gabriela Aparecida Lima Mario Oliveira Lopes Martins Rodrigo Alvaro Brandão 《Lasers in medical science》2021,36(8):1741-1749
Lasers in Medical Science - Physical activity raises body temperature. However, the literature does not contain studies about whether the employment of hotobiomodulation (PMB) could significantly... 相似文献
42.
Chimello-Sousa Daniela Thomazatti Lavez Geovane Praxedes Fernandes Roger Rodrigo Tavares Milla Sprone Rosa Adalberto Luiz Siessere Selma Regalo Simone Cecílio Hallak Bombonato-Prado Karina Fittipaldi 《Lasers in medical science》2021,36(9):1979-1988
Lasers in Medical Science - The purpose of this study is to analyze the influence of InGaAlP diode laser (660 nm) with or without an odontogenic medium (OM) in the functional activity of... 相似文献
43.
Marysol Luna Jason D Guss Laura S Vasquez-Bolanos Macy Castaneda Manuela Vargas Rojas Jasmin M Strong Denise A Alabi Sophie D Dornevil Jacob C Nixon Erik A Taylor Eve Donnelly Xueyan Fu M Kyla Shea Sarah L Booth Rodrigo Bicalho Christopher J Hernandez 《Journal of bone and mineral research》2021,36(9):1823-1834
Modifications to the constituents of the gut microbiome influence bone density and tissue-level strength, but the specific microbial components that influence tissue-level strength in bone are not known. Here, we selectively modify constituents of the gut microbiota using narrow-spectrum antibiotics to identify components of the microbiome associated with changes in bone mechanical and material properties. Male C57BL/6J mice (4 weeks) were divided into seven groups (n = 7–10/group) and had taxa within the gut microbiome removed through dosing with: (i) ampicillin; (ii) neomycin; (iii) vancomycin; (iv) metronidazole; (v) a cocktail of all four antibiotics together (with zero-calorie sweetener to ensure intake); (vi) zero-calorie sweetener only; or (vii) no additive (untreated) for 12 weeks. Individual antibiotics remove only some taxa from the gut, while the cocktail of all four removes almost all microbes. After accounting for differences in geometry, whole bone strength was reduced in animals with gut microbiome modified by neomycin (−28%, p = 0.002) and was increased in the group in which the gut microbiome was altered by sweetener alone (+39%, p < 0.001). Analysis of the fecal microbiota detected seven lower-ranked taxa differentially abundant in animals with impaired tissue-level strength and 14 differentially abundant taxa associated with increased tissue-level strength. Histological and serum markers of bone turnover and trabecular bone volume per tissue volume (BV/TV) did not differ among groups. These findings demonstrate that modifications to the taxonomic components of the gut microbiome have the potential to decrease or increase tissue-level strength of bone independent of bone quantity and without noticeable changes in bone turnover. © 2021 American Society for Bone and Mineral Research (ASBMR). 相似文献
44.
Arturo Blazquez-Navarro Chantip Dang-Heine Patrizia Wehler Toralf Roch Chris Bauer Sindy Neumann Rodrigo Blazquez-Navarro Andriy Kurchenko Kerstin Wolk Robert Sabat Timm H. Westhoff Sven Olek Oliver Thomusch Harald Seitz Petra Reinke Christian Hugo Birgit Sawitzki Michal Or-Guil Nina Babel 《Transplant international》2021,34(9):1680-1688
Epstein–Barr virus (EBV) reactivation is a very common and potentially lethal complication of renal transplantation. However, its risk factors and effects on transplant outcome are not well known. Here, we have analysed a large, multi-centre cohort (N = 512) in which 18.4% of the patients experienced EBV reactivation during the first post-transplant year. The patients were characterized pre-transplant and two weeks post-transplant by a multi-level biomarker panel. EBV reactivation was episodic for most patients, only 12 patients showed prolonged viraemia for over four months. Pre-transplant EBV shedding and male sex were associated with significantly increased incidence of post-transplant EBV reactivation. Importantly, we also identified a significant association of post-transplant EBV with acute rejection and with decreased haemoglobin levels. No further severe complications associated with EBV, either episodic or chronic, could be detected. Our data suggest that despite relatively frequent EBV reactivation, it had no association with serious complications during the first post-transplantation year. EBV shedding prior to transplantation could be employed as biomarkers for personalized immunosuppressive therapy. In summary, our results support the employed immunosuppressive regimes as relatively safe with regard to EBV. However, long-term studies are paramount to support these conclusions. 相似文献
45.
Rodrigo Rodrigues Pessoa Paul Maroni Janet Kukreja Simon P. Kim 《Translational andrology and urology》2021,10(5):2158
Radical prostatectomy (RP) has undergone a remarkable transformation from open to minimally-invasive surgery over the last two decades. However, it is important to recognize there is still conflicting evidence regarding key outcomes. We aimed to summarize current literature on comparative effectiveness of robotic and open RP for key outcomes including oncologic results, health-related quality of life (HRQOL) measures, safety and postoperative complications, and healthcare costs. The bulk of the paper will discuss and interpret limitations of current data. Finally, we will also highlight future directions of both surgical approaches and its potential impact on health care delivery. 相似文献
46.
47.
Solange Cailleaux Rodrigo A. B. Lopes-Martins Flávio Aimbire Renato S. B. Cordeiro E. Tibiriçá 《Naunyn-Schmiedeberg's archives of pharmacology》1999,359(6):505-511
The hypothesis that platelet-activating factor (PAF) plays a role in the modulation of the vasomotor tone and blood pressure
was put forward by our group in previous in vivo studies in anaesthetised rabbits. The present study was undertaken to investigate
the putative role of this lipid mediator in the vascular reactivity of the renal circulation, using the experimental model
of the isolated perfused rabbit kidney. Dose-response curves to noradrenaline-induced vasoconstriction were performed before
and after continuous infusions of two different PAF-receptor antagonists (WEB 2086 and yangambin) and of the phospholipase
A2 inhibitor mepacrine. The increases in renal perfusion pressure elicited by noradrenaline were potentiated by all the above-mentioned
treatments in a dose-dependent manner. Moreover, prostaglandin F2α-induced vasoconstriction was also potentiated by the administration of the PAF receptor antagonists and mepacrine. Furthermore,
the administration of PAF into the renal circulation induced dose-related and long-lasting vasodilator responses, which were
blocked by the PAF receptor antagonists. Nevertheless, PAF-induced renal vasodilation was also abolished by a pretreatment
with mepacrine or with the cyclooxygenase inhibitor indomethacin, suggesting that it enhances the secondary formation of vasodilator
arachidonic acid metabolites. The data indicate that PAF is involved in the modulation of the vasomotor tone in the renal
circulation, through the release of cyclooxygenase products, constituting an additional mechanism of modulation of smooth
muscle cell contractility to the ones exerted by well-known vasoactive substances of endothelial origin such as nitric oxide.
Received: 20 April 1998 / Accepted: 5 March 1999 相似文献
48.
Alosetron relieves pain and improves bowel function compared with mebeverine in female nonconstipated irritable bowel syndrome patients 总被引:5,自引:0,他引:5
Jones RH Holtmann G Rodrigo L Ehsanullah RS Crompton PM Jacques LA Mills JG 《Alimentary pharmacology & therapeutics》1999,13(11):1419-1427
BACKGROUND: Irritable bowel syndrome is one of the most common gastrointestinal disorders, yet no therapy convincingly controls the multiple symptoms of this syndrome. AIM: To compare the efficacy and tolerability of the new 5-HT3-receptor antagonist alosetron and the smooth muscle relaxant mebeverine in a double-blind, multicentre, randomized trial. METHODS: Six hundred and twenty-three nonconstipated females with irritable bowel syndrome were randomized to receive alosetron 1 mg twice daily (n=319) or mebeverine 135 mg three times daily (n=304) for 12 weeks, followed by a 4-week post-treatment period. The primary efficacy end-point was monthly responders for adequate relief of irritable bowel syndrome related abdominal pain and discomfort (defined as patients reporting adequate relief on at least 2 out of 4 weeks). Secondary end-points included assessments of bowel function, including urgency, stool frequency and stool consistency. RESULTS: There were significantly more responders in the alosetron group compared with mebeverine at months 2 and 3 (P < 0.01). Compared with mebeverine, the alosetron group experienced significant decreases in proportion of days with urgency and mean stool frequency, and had firmer stools within 1 week of starting treatment. A similar proportion of patients reported adverse events in the two treatment groups. CONCLUSIONS: In nonconstipated female irritable bowel syndrome patients, alosetron is significantly more effective than mebeverine in improving symptoms. 相似文献
49.