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181.
Tracheal carcinoma was diagnosed in a 10-year-old male Spitz dog suffering from dyspnoea. The tumour was poorly differentiated, but desmosomes were seen by transmission electron microscopy. 相似文献
182.
183.
OBJECTIVE: To report two cases demonstrating an interaction between danazol and warfarin, resulting in the potentiation of warfarin's effect and bleeding complications. DATA SOURCES: Case reports, review articles, and studies identified by MEDLINE. STUDY SELECTION: All published English-language reports involving danazol and warfarin interactions were reviewed. DATA SYNTHESIS: Danazol, a synthetic testosterone derivative, is used in the treatment of endometriosis, fibrocystic breast disease, menorrhagia protein C deficiency, and hemophilia. We describe two cases including an interaction between danazol and warfarin, resulting in bleeding complications. There are at least two other reported cases of this interaction. This interaction may be attributable to several mechanisms. Danazol may inhibit the metabolism of warfarin and/or it may have a direct effect on the coagulation and fibrinolytic systems. CONCLUSIONS: Based on this report and other published cases, clinicians must be aware that danazol may increase the anticoagulant effect of warfarin. Patients receiving warfarin who are prescribed danazol must be monitored closely to prevent excessive anticoagulation and subsequent bleeding. Studies are needed to determine the frequency of this interaction and its underlying mechanisms. 相似文献
184.
Winnie CW Chu Bobby KW Ng Albert M Li Tsz-ping Lam Wynnie WM Lam Jack CY Cheng 《Journal of orthopaedic surgery and research》2007,2(1):20-7
Background
Restrictive impairment is the commonest reported pulmonary deficit in AIS, which improves following surgical operation. However, exact mechanism of how improvement is brought about is unknown. Dynamic fast breath-hold (BH)-MR imaging is a recent advance which provides direct quantitative visual assessment of pulmonary function. By using above technique, change in lung volume, chest wall and diaphragmatic motion in AIS patients before and six months after posterior spinal fusion surgery were measured. 相似文献185.
NJ Hardcastle†§ AJ Tunbridge‡ KW Shum† DH Dockrell‡§ ST Green‡ 《Journal of the European Academy of Dermatology and Venereology》2005,19(5):631-633
We present a case where alopecia occurred with severe seborrhoeic dermatitis associated with the commencement of combination antiretroviral therapy for acute retroviral syndrome. We postulate that the eruption could represent a novel manifestation in association with immunological response to antiretroviral therapy. 相似文献
186.
187.
Vijaya L Damaraju David Y Bouffard Clarence KW Wong Marilyn L Clarke John R Mackey Lorraine Leblond Carol E Cass Mike Grey Henriette Gourdeau 《BMC cancer》2007,7(1):121
Background
Gemcitabine, a deoxycytidine nucleoside analog, is the current standard chemotherapy used as first-line treatment for patients with locally advanced or metastatic cancer of the pancreas, and extends life survival by 5.7 months. Advanced pancreatic cancer thus remains a highly unmet medical need and new therapeutic agents are required for this patient population. Troxacitabine (Troxatyl™) is the first unnatural L-nucleoside analog to show potent preclinical antitumor activity and is currently under clinical investigation. Troxacitabine was recently evaluated as a first-line therapy in 54 patients with advanced adenocarcinoma of the pancreas and gave comparable overall results to those reported with gemcitabine in recently published randomized trials. 相似文献188.
Letts VA Mahaffey CL Beyer B Frankel WN 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(6):2123-2128
The voltage-dependent calcium channel gamma4 subunit protein, CACNG4, is closely related to the gamma2 subunit, CACNG2. Both are expressed primarily in the brain and share 53% amino acid identity. The Cacng2 gene is disrupted in the stargazer mouse, with its distinctive phenotype including ataxia, frequent absence seizure episodes, and head elevation. A disruption within Cacng4 was engineered to assess its particular function. The homozygous Cacng4-targeted mutant mouse appeared normal with no ataxic gait or absence seizures, suggesting that other members of the gamma subunit family might functionally compensate for the absence of CACNG4. To test this hypothesis, the targeted Cacng4 mutation was combined with alleles of Cacng2. Absence seizures were observed in combination with the stargazer 3J mutation, which itself does not have seizures, and increased seizure activity was observed in combination with the waggler allele. Furthermore, within the corticothalamic loop, where absence seizures arise, CACNG4 expression is restricted to the thalamus. Our studies show that the CACNG4 protein has seizure suppressing activity, but this effect is revealed only when CACNG2 expression is also compromised, suggesting that CACNG subunits have in vivo overlapping functions. 相似文献
189.
Despite the high prevalence of sexual desire disorders, little is known about their biological underpinnings in humans. Animal
studies suggest that dopamine is involved in appetitive sexual behavior; thus, one aim of this study was to elucidate that
relationship in humans. This study used measurement of the acoustic startle response (ASR) and prepulse inhibition of the
startle response (PPI) as psychophysiological indicators of changes in motivational states to assess the potential relation
between sexual desire and appetitive motivation in humans. Responses to sexually provocative stimuli consisting of single
nude men and single nude women in a sample of 153 participants (77 men, 76 women) were assessed. The results indicated that
ASR was attenuated after exposure to appetitive stimuli (i.e., sexually provocative pictures of attractive individuals) to
a greater extent among participants with higher levels of sexual desire, as measured by the Sexual Desire Inventory-2 (Spector,
I. P., Carey, M. P., & Steinberg, L. (1996).Journal of Sex&Marital Therapy,22,175–190). In addition, PPI was inversely associated with subjective ratings across stimuli such that greater subjective levels
of desire were correlated with lower levels of PPI. In general, these results suggest that individuals with lower levels of
sexual desire may have a diminished physiological response to appetitive sexual stimuli. 相似文献
190.
Kandzari DE Granger CB Simoons ML White HD Simes J Mahaffey KW Gore J Weaver WD Longstreth WT Stebbins A Lee KL Califf RM Topol EJ;Global Utilization of Streptokinase tPA for Occluded Arteries-I Investigators 《The American journal of cardiology》2004,93(4):458-461
Of 592 patients in the Global Utilization of Streptokinase and tPA for Occluded Arteries-I trial who had a stroke during initial hospitalization, the risk for intracranial hemorrhage was significantly greater in those with recent facial or head trauma (odds ratio 13.0, 95% confidence interval 3.4 to 85.5); dementia was additionally associated with an increased risk for intracranial hemorrhage (odds ratio 3.4, 95% confidence interval 1.2 to 10.2). Because facial or head trauma may greatly influence treatment decisions, this risk factor should be incorporated into models designed to estimate the risks and benefits of fibrinolytic therapy. 相似文献