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51.
52.
JA Grunt ID Schwartz C Buchanan CP Howard 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(6):631-633
Seven children with significant idiopathic short stature (SISS) whose heights were significantly below the third percentile (SD score for height —2.5 to —3.5) and who had normal levels of growth hormone (GH) were treated with growth hormone releasing hormone (GH-RH) in a dose of 30 /μg/kg/day. Therapy was discontinued if patients failed to increase their rates of growth by more than 2.0 cm/year over their pre-therapy growth rate. Treatment was discontinued in two of the patients after 12 months but was continued in the other five for 24 months. These data demonstrate that some patients with SISS grow well during the first 2 years of treatment with GH-RH. 相似文献
53.
K. M. Kilbride F. L. Paveglio A. L. AltstattRID=""ID="" <E>Present address:</E> Chiswell Lane Silver Spring MD USA W. G. Henry C. A. JanikRID=""ID="" <E>Present address:</E> Palo Verde Albuquerque NM USA 《Archives of environmental contamination and toxicology》1998,35(2):236-248
Throughout the western United States, studies have identified various detrimental effects of contaminants to aquatic biota
from the use of agricultural drainage water for management of arid wetlands. However, little is known about the relative contributions
of contaminant loading from pollutants dissolved in water compared with those carried by drifting material (e.g., detritus) associated with drainage water. Consequently, we determined loading rates for contaminants dissolved in water and
those incorporated by drifting material for drainage (Diagonal Drain) as well as fresh (S-Line Canal) water used for wetland
management at Stillwater National Wildlife Refuge (SNWR), Nevada during the early, middle, and late periods of the irrigation
season (June through mid-November) in 1993. We found loading rates for trace elements throughout the irrigation season were
almost entirely (> 98%) associated with contaminants dissolved in the water rather than incorporated by drift. Although drift
contributed little to the total loading for trace elements to SNWR wetlands, contaminant concentrations were much greater
in drift compared with those dissolved in water. Loading rates for dissolved As, B, Hg, and total dissolved solids (TDS) differed
among periods for the Diagonal Drain. Along the Diagonal Drain, loading rates for dissolved As, B, Hg, Mo, unionized ammonia
(NH3-N), TDS, and Zn differed among its three sampling sites. B was the only trace element with differences in loading rates for
drift among periods from the Diagonal Drain. In contrast, loading rates for As, B, Cr, Cu, Hg, Se, and Zn in drift differed
among periods for the S-Line Canal. Along Diagonal Drain, loading rates in drift for B (middle and late periods), Cr, Cu,
and Zn differed among sites. Hg (xˉ ≥ 12.0 ng/L) and NH3-N (xˉ ≥ 0.985 mg/L) dissolved in water as well as B (xˉ ≥ 97.4 μg/g DW) and Hg (xˉ ≥ 0.461 μg/g DW) in drift from the Diagonal
Drain and S-Line Canal exceeded screening levels (SLs) for protection of aquatic biota throughout the irrigation season. Dissolved
As (xˉ ≥ 0.0426 mg/L) in water from the Diagonal Drain during all periods exceeded the SL for protection of aquatic biota.
Dissolved B (xˉ = 1.03 mg/L) in water from the Diagonal Drain during the early period exceeded the SL for protection of aquatic
biota.
Received: 18 September 1997/Accepted: 5 February 1998 相似文献
54.
To identify the predictive factors for testicular sperm extraction (TESE)
and to understand the pathology associated with TESE, we carried out a
prospective study in 40 consecutive men with azoospermia due to primary
gonadal failure. The main outcome measure was the retrieval of at least one
testicular spermatozoon. Endocrine and biophysical profiles, testicular
histology, Johnsen score and testicular spermatids were used as predictors
of sperm extraction. Spermatogenesis was quantified with the Johnsen score.
A variable pattern of spermatogenesis was common, being present in 20 (50%)
patients. Visualisation of testicular spermatids on testicular histology
showed a strong association with TESE (P < 0.0001). Statistically
significant differences were detected in plasma follicle stimulating
hormone (FSH) and testicular volume between patients who had
hypospermatogenesis and Sertoli cell-only or maturation arrest. There were
no significant differences in Johnsen score, biophysical and endocrine
profiles between the groups with successful and failed TESE. However, a
statistically significant trend occurred with changes in histological
pattern [chi2 for trend, P = 0.001; Pearson's coefficient (r) = 0.6],
Johnsen score (P = 0.022; r = 0.5), testicular volume (P = 0.01; r = 0.5)
and plasma FSH concentrations (P = 0.044; r = 0.4), albeit to a limited
degree. Difference in the interpretation of histological patterns with
different assessors was observed. The type of occupation or risk factors
for azoospermia showed no association with testicular pathology or TESE.
Variable histological patterns in different tubules in the same individual
may explain the poor correlation of TESE with endocrine and biophysical
profiles, Johnsen score and histological pattern. Differences in the amount
of tissue used for TESE and histopathology, and misinterpretation of
testicular histology rather than failure to quantify spermatogenesis may
explain the poor correlation between histological patterns and TESE.
Testicular spermatids predicted TESE. However, considerable overlap in
values means that no single variable can provide a perfect discrimination
between the groups with successful and failed TESE.
相似文献
55.
Cytokines and immuno-endocrine factors in recurrent miscarriage 总被引:7,自引:0,他引:7
Recurrent miscarriage remains an enigma. The main aetiologiesare endocrinological, immunological and unexplained. With thegrowth in molecular biology, it is now possible to look at theeffect of these aetiologies in more detail, allowing greaterunderstanding of the underlying pathogenesis. Keywords: cytokines/recurrent miscarriage 相似文献
56.
Two modes of embryo transfer, uterine and tubal, were compared following
natural cycle in-vitro fertilization (IVF). Only patients with patent
Fallopian tubes were included in the study. Tubal embryo transfer was
performed by retrograde tubal cannulation without analgesia on an
outpatient basis. Tubal transfer conferred no benefit compared with uterine
transfer in male factor infertility with positive fertilization (pregnancy
rates of 15.8% in both groups). Although tubal embryo transfer in the
patients with unexplained infertility improved the pregnancy rates from
7.8% in uterine transfer (5/64) to 17.6% in the tubal transfer group
(13/74), this improvement was not statistically significant.
相似文献
57.
58.
Primitive human hematopoietic precursors express Bcl-x but not Bcl-2 总被引:10,自引:3,他引:7
59.
60.
Laszlo?Kunos Peter?Horvath Adrian?Kis David?Laszlo?Tarnoki Adam?Domonkos?Tarnoki Zsofia?Lazar Andras?BikovEmail authorView authors OrcID profile 《Lung》2018,196(4):417-424