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SangMyung Lee YungHee Kho ByungSun Min JinHee Kim MinKyun Na ShinJyung Kang HackYoung Maeng KiHwan Bae 《Archives of pharmacal research》2001,24(6):524-526
Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED50 values of 7.5, 7.5, 4.9 microg/ml, respectively. 相似文献
666.
Background
Acculturation is one of the determinants of mental health among immigrants. Evaluating adaptation to the host culture is insufficient, since immigrants will develop various degrees of bi- or multicultural identity. However, mental health professionals lack simple and easy to use instruments to guide them with bicultural identity evaluation in their practice. Our aim was to develop such an instrument to be used for clinical purposes among economical migrants from three South European countries living in Geneva, Switzerland.Methods
We adapted from existing instruments a 24 item bi-dimensional scale to assess involvement in both culture of origin and host culture. The study included 93 immigrant adults from three south European countries (Italy, Portugal and Spain). Thirty-eight patients were recruited in an outpatient treatment program for alcohol-related problems and 55 participants were hospital employees.Results
The questionnaire was rated as easy or rather easy by 97.8% of participants. Median time to complete it was 5 minutes. The instrument allowed discriminating between patients and healthy subjects, with scores for Swiss culture significantly higher among hospital workers. The subscales related to culture of origin and host culture displayed adequate internal consistency (Cronbach's alpha 0.77 and 0.73 respectively).Conclusion
It is possible to assist clinicians' assessment of cultural identity of Italian, Portuguese and Spanish economical immigrants in Switzerland with a single and easy to use instrument. 相似文献667.
In this article, we first review a study showing that the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine leads to rapid, robust, and relatively sustained antidepressant effects in
patients with treatment-resistant major depression. We then discuss our hypothesis that the therapeutic effects of monoaminergic
antidepressants and ketamine may be mediated by increased AMPA-to-NMDA glutamate receptor throughput in critical neuronal
circuits. We hypothesize that ketamine directly mediates this throughput, whereas monoaminergic antidepressants work indirectly
and gradually; this may explain, in part, the lag of onset of several weeks to months that is observed with traditional antidepressants. 相似文献
668.
Ji Hye Han Tae Jung Oh Ghayoung Lee Hyo Jin Maeng Dong Hwa Lee Kyoung Min Kim Sung Hee Choi Hak Chul Jang Hye Seung Lee Kyong Soo Park Young-Bum Kim Soo Lim 《Diabetologia》2017,60(2):364-376
Aims/hypothesis
A recent large clinical study has shown that empagliflozin has a lower rate of cardiovascular and all-cause mortality when compared with placebo in patients with type 2 diabetes. We investigated the effect of empagliflozin (compared with glimepiride) on the progression of atherosclerosis, and its possible mechanisms of action.Methods
Forty-eight 5-week-old male ApoE ?/? mice were fed a western diet for 20 weeks and divided into four groups: control (saline, 154 mmol/l NaCl), glimepiride 0.1 mg/kg, empagliflozin 1 mg/kg and empagliflozin 3 mg/kg (n?=?12/group). Plaque size and composition in the aortic arch/valve areas and cardiovascular risk variables in the blood and tissues were evaluated. Insulin resistance was estimated by HOMA and adiponectin levels. Body composition was determined using dual-energy x-ray absorptiometry.Results
After 8 weeks of treatment, the empagliflozin and glimepiride groups exhibited decreased blood glucose levels. Atherosclerotic plaque areas in the aortic arch/valve were significantly smaller in the empagliflozin groups than in the control or glimepiride groups. Insulin resistance and circulating concentrations of TNF-α, IL-6, monocyte chemoattractant protein-1 (MCP-1), serum amyloid A and urinary microalbumin decreased after empagliflozin treatment, and this significantly correlated with plaque size. Empagliflozin treatment reduced weight and fat mass, lipid droplets in the liver, fat cell size, mRNA expression of Tnf, Il6 and Mcp-1 (also known as Ccl2) and the infiltration of inflammatory cells in plaque and adipose tissue compared with the control or glimepiride group. Empagliflozin treatment increased adiponectin levels.Conclusions/interpretation
Improvements in inflammation and insulin resistance seem to be mechanisms involved in the mitigation of atherosclerosis by empagliflozin.669.
Daniel D Maeng Dennis P Scanlon Michael E Chernew Tim Gronniger Walter P Wodchis Catherine G McLaughlin 《Health services research》2010,45(4):1005-1023
ObjectiveTo examine the extent to which health plan quality measures capture physician practice patterns rather than plan characteristics.ConclusionsStandard health plan performance measures reflect physician practice patterns rather than plans'' effort to improve quality. This implies that more provider-oriented measurement, such as would be possible with accountable care organizations or medical homes, may facilitate patient decision making and provide further incentives to improve performance. 相似文献
670.
Analysis of structure–function network decoupling in the brain systems of spastic diplegic cerebral palsy
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Dongha Lee Chongwon Pae Jong Doo Lee Eun Sook Park Sung‐Rae Cho Min‐Hee Um Seung‐Koo Lee Maeng‐Keun Oh Hae‐Jeong Park 《Human brain mapping》2017,38(10):5292-5306
Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure–function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting‐state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients. In the whole‐brain network of patients, significantly reduced global network efficiency compared to healthy controls were found in the structural networks but not in the functional networks, resulting in reduced structural–functional coupling. On the contrary, the motor network of patients had a significantly lower functional network efficiency over the intact structural network and a lower structure–function coupling than the control group. This reduced coupling but reverse directionality in the whole‐brain and motor networks of patients was prominent particularly between the probabilistic structural and partial correlation‐based functional networks. Intact (or less deficient) functional network over impaired structural networks of the whole brain and highly impaired functional network topology over the intact structural motor network might subserve relatively preserved cognitions and impaired motor functions in cerebral palsy. This study suggests that the structure–function relationship, evaluated specifically using sparse functional connectivity, may reveal important clues to functional reorganization in cerebral palsy. Hum Brain Mapp 38:5292–5306, 2017. © 2017 Wiley Periodicals, Inc. 相似文献