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LL Su M Rauff YH Chan N Mohamad Suphan TP Lau A Biswas YS Chong 《BJOG : an international journal of obstetrics and gynaecology》2009,116(11):1461-1466
Objective Prevention of postpartum haemorrhage is essential in the pursuit of improved health care for women. However, limited literature is available for comparing the use of oxytocin agonist carbetocin with syntometrine in women undergoing vaginal deliveries. We aimed to compare intramuscular carbetocin with intramuscular syntometrine for the routine prevention of postpartum haemorrhage in women who deliver vaginally.
Design Prospective double-blind randomised controlled trial.
Setting Tertiary referral centre.
Population Pregnant women with no contraindication for vaginal delivery recruited from January 2005 to April 2008.
Methods Participants were randomised to receive either syntometrine or carbetocin during the third stage of labour.
Main outcome measures Primary outcome measure was postpartum haemorrhage requiring additional uterotonics. Secondary outcome measures were the incidence of postpartum haemorrhage (≥500 ml), severe postpartum haemorrhage (≥1000 ml) and adverse effects profile.
Results Women in the carbetocin group (13.5%) and in the syntometrine group (16.8%) had postpartum haemorrhage requiring additional uterotonics ( P = 0.384). 1.6% of women in each group had postpartum haemorrhage ( P = 1.0) and the estimated blood loss during the third stage of labour was similar between the two groups ( P = 0.294). Women who had syntometrine were four times more likely to experience nausea (RR = 4.2; 95% CI 2.2–7.8) and vomiting (RR = 4.3; 95% CI 1.9–9.5) compared with women who had carbetocin. Tremor, sweating, retching and uterine pain were also more likely in the syntometrine group compared with the carbetocin group ( P < 0.05).
Conclusions Carbetocin has an efficacy similar to syntometrine for prevention of postpartum haemorrhage, but is associated with less adverse effects. 相似文献
Design Prospective double-blind randomised controlled trial.
Setting Tertiary referral centre.
Population Pregnant women with no contraindication for vaginal delivery recruited from January 2005 to April 2008.
Methods Participants were randomised to receive either syntometrine or carbetocin during the third stage of labour.
Main outcome measures Primary outcome measure was postpartum haemorrhage requiring additional uterotonics. Secondary outcome measures were the incidence of postpartum haemorrhage (≥500 ml), severe postpartum haemorrhage (≥1000 ml) and adverse effects profile.
Results Women in the carbetocin group (13.5%) and in the syntometrine group (16.8%) had postpartum haemorrhage requiring additional uterotonics ( P = 0.384). 1.6% of women in each group had postpartum haemorrhage ( P = 1.0) and the estimated blood loss during the third stage of labour was similar between the two groups ( P = 0.294). Women who had syntometrine were four times more likely to experience nausea (RR = 4.2; 95% CI 2.2–7.8) and vomiting (RR = 4.3; 95% CI 1.9–9.5) compared with women who had carbetocin. Tremor, sweating, retching and uterine pain were also more likely in the syntometrine group compared with the carbetocin group ( P < 0.05).
Conclusions Carbetocin has an efficacy similar to syntometrine for prevention of postpartum haemorrhage, but is associated with less adverse effects. 相似文献
653.
Circulating Endothelial Cells and Circulating Progenitor Cells in Breast Cancer: Relationship to Endothelial Damage/Dysfunction/Apoptosis, Clinicopathologic Factors, and the Nottingham Prognostic Index 下载免费PDF全文
Patrick KY Goon Gregory YH Lip Paul S Stonelake Andrew D Blann 《Neoplasia (New York, N.Y.)》2009,11(8):771-779
Background and Methods 相似文献
654.
This study was to investigate the role of complementary and alternative medicine in the prevention and treatment of benign prostatic hyperplasia. For this purpose, a randomized, double-blind, placebo-controlled trial was performed over 12 months on 47 benign prostatic hyperplasia patients with average age of 53.3 years and international prostate symptom score over 8. Subjects received either sweet potato starch (group A, placebo, 320 mg/day), pumpkin seed oil (group B, 320 mg/day), saw palmetto oil (group C, 320 mg/day) or pumpkin seed oil plus saw palmetto oil (group D, each 320 mg/day). International prostate symptom score, quality of life, serum prostate specific antigen, prostate volume and maximal urinary flow rate were measured. In groups B, C and D, the international prostate symptom score were reduced by 3 months. Quality of life score was improved after 6 months in group D, while those of groups B and C were improved after 3 months, compared to the baseline value. Serum prostate specific antigen was reduced only in group D after 3 months, but no difference was observed in prostate volume in all treatment groups. Maximal urinary flow rate were gradually improved in groups B and C, with statistical significance after 6 months in group B and after 12 months in group C. None of the parameters were significantly improved by combined treatment with pumpkin seed oil and saw palmetto oil. From these results, it is suggested that administrations of pumpkin seed oil and saw palmetto oil are clinically safe and may be effective as complementary and alternative medicine treatments for benign prostatic hyperplasia. 相似文献
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Ji Hun Kim Jae Hyuck Chang Sung Min Nam Mi Jeong Lee Il Ho Maeng Jin Young Park Yun Sun Im Tae Ho Kim Chang Whan Kim Sok Won Han 《World journal of gastroenterology : WJG》2012,18(41):5990-5993
A 57-year-old man presented with a 2-wk history of painless jaundice and weight loss. He had a large ill-defined enhancing mass-like lesion in the uncinate process of the pancreas with stricture of the distal common bile duct. Aspiration cytology of the pancreatic mass demonstrated inflammatory cells without evidence of malignancy. Total serum immunoglobulin G level was slightly elevated, but IgG4 level was normal. After the 2-wk 40 mg prednisolone trial, the patient’s symptoms and bilirubin level improved significantly. A follow-up computed tomography (CT) scan showed a dramatic resolution of the pancreatic lesion. A low dose steroid was continued. After six months he self-discontinued prednisolone for 3 wk, and was presented with jaundice again. A CT scan showed newly developed intrahepatic biliary dilatation and marked concentric wall thickening of the common hepatic duct and the proximal common bile duct without pancreatic aggravation. The patient’s IgG4 level was elevated to 2.51 g/L. Prednisolone was started again, after which his serum bilirubin level became normal and the thickening of the bile duct was resolved. This case suggests that autoimmune pancreatitis can progress to other organs that are not involved at the initial diagnosis, even with sustained pancreatic remission. 相似文献
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