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Joep WM van Oorschot Hamza El Aidi Sanne J Jansen of Lorkeers Johannes MIH Gho Martijn Froeling Fredy Visser Steven AJ Chamuleau Pieter A Doevendans Peter R Luijten Tim Leiner Jaco JM Zwanenburg 《Journal of cardiovascular magnetic resonance》2014,16(1)
Background
Detection of cardiac fibrosis based on endogenous magnetic resonance (MR) characteristics of the myocardium would yield a measurement that can provide quantitative information, is independent of contrast agent concentration, renal function and timing. In ex vivo myocardial infarction (MI) tissue, it has been shown that a significantly higher T1ρ is found in the MI region, and studies in animal models of chronic MI showed the first in vivo evidence for the ability to detect myocardial fibrosis with native T1ρ-mapping. In this study we aimed to translate and validate T1ρ-mapping for endogenous detection of chronic MI in patients.Methods
We first performed a study in a porcine animal model of chronic MI to validate the implementation of T1ρ-mapping on a clinical cardiovascular MR scanner and studied the correlation with histology. Subsequently a clinical protocol was developed, to assess the feasibility of scar tissue detection with native T1ρ-mapping in patients (n = 21) with chronic MI, and correlated with gold standard late gadolinium enhancement (LGE) CMR. Four T1ρ-weighted images were acquired using a spin-lock preparation pulse with varying duration (0, 13, 27, 45 ms) and an amplitude of 750 Hz, and a T1ρ-map was calculated. The resulting T1ρ-maps and LGE images were scored qualitatively for the presence and extent of myocardial scarring using the 17-segment AHA model.Results
In the animal model (n = 9) a significantly higher T1ρ relaxation time was found in the infarct region (61 ± 11 ms), compared to healthy remote myocardium (36 ± 4 ms) . In patients a higher T1ρ relaxation time (79 ± 11 ms) was found in the infarct region than in remote myocardium (54 ± 6 ms). Overlap in the scoring of scar tissue on LGE images and T1ρ-maps was 74%.Conclusion
We have shown the feasibility of native T1ρ-mapping for detection of infarct area in patients with a chronic myocardial infarction. In the near future, improvements on the T1ρ -mapping sequence could provide a higher sensitivity and specificity. This endogenous method could be an alternative for LGE imaging, and provide additional quantitative information on myocardial tissue characteristics. 相似文献22.
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MAURITS S. BUITEN M.D. MIHÁLY K. DE BIE M.D. AAFKE C. VAN DER HEIJDEN M.D. JORIS I. ROTMANS M.D. Ph.D. MARIANNE BOOTSMA M.D. Ph.D. J.H. MARC GROENEVELD M.D. Ph.D. RON WOLTERBEEK M.D. TON J. RABELINK M.D. Ph.D. J.WOUTER JUKEMA M.D. Ph.D. MARTIN J. SCHALIJ M.D. Ph.D. LIESELOT VAN ERVEN M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2014,25(9):998-1004
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Mitchell D Anjou MScOptom FACO Andrea I Boudville MIH BSc Hugh R Taylor AC MD 《Clinical & experimental optometry》2012,95(6):615-617
The gap in vision and ocular health between Aboriginal and Torres Strait Islander Australians and other Australians continues to be significant, yet three‐quarters of the identified Aboriginal and Torres Strait Islander population live in urban and regional areas of Australia where existing eye‐care services are available. In urban Australia, an improvement in the access and use of eye‐health services is required to provide equitable eye‐care outcomes for Australia's Indigenous peoples. Optometric services need to be available within Aboriginal Health Services in urban areas to effectively close the gap for vision. 相似文献
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Robert R. Lauwerys MD DSc MIH Jean P. Buchet DSc 《Archives of environmental & occupational health》2013,68(2):65-68
In workers exposed to an average atmospheric mercury vapor concentration below the current threshold limit value (TLV, 0.050 mg/cu m), the following biological changes were detected: increased blood and urine mercury concentrations, increased plasma galactosidase and plasma catalase activities, decreased red blood cell (RBC) cholinesterase activity. A significant correlation was found between airborne mercury level and urinary mercury concentration (r = 0.47), between mercury concentration in blood and in urine (r = 0.36), and between airborne mercury concentration and RBC cholinesterase inhibition (r = 0.33). Serum cholinesterase, RBC δ-aminolevulinic acid (ALA) dehydratase, and urine ALA levels were normal. No significant anomalies were found on the amino acid chromatographs and protein electrophoresis of serum and urine. 相似文献
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Edward Zimbudzi BSc RN MIH PhD Clement Lo MBBS PhD FRACP Sanjeeva Ranasinha M Epi MSc Tim Usherwood BSc MD MBBS FRACGP FRCP FAICD Kevan R. Polkinghorne BHB MBChB FRACP MClinEpi PhD Gregory Fulcher MBBS MD FRACP Martin Gallagher MBBS FRACP MPH PhD Stephen Jan BEc MEc PhD Alan Cass BA MBBS Grad Dip ClinEpi FRACP PhD Rowan Walker MBBS FRACP MD MPH Grant Russell MBBS FRACGP MFM PhD Greg Johnson B Pharm Dip Hosp Pharm MBA Peter G. Kerr MBBS PhD FRACP Sophia Zoungas MBBS PhD FRACP 《Health expectations》2023,26(6):2584-2593