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21.
Naoki Shiraishi Kenichiro Kitamura Yukimasa Kohda Kunitoshi Iseki Kimio Tomita 《Clinical and experimental nephrology》2014,18(3):461-468
Background
Nephrosclerosis/ischemic nephropathy (NS/IN) ranks third among renal diseases requiring dialysis in Japan. Although it is an important renal disease in terms of frequency, its prevalence, new incidence, and risk factors are not fully elucidated.Methods
We analyzed the prevalence, incidence, concurrent diseases, and risk factors of NS/IN by using data from specific health checkups of Kumamoto citizens between 2008 and 2010.Results
Although the prevalence of NS/IN was 1?2 % in people in their 40s, it increased sharply with age, reaching 17.6 % in people aged 70–74 years. The incidence of new NS/IN was 0.4?0.5 % per year. In multivariate logistic regression analysis, factors such as age, male gender, body mass index (BMI), hyperuricemia, hypertension, and dyslipidemia correlated with NS/IN. When risk factors associated with NS/IN progress were evaluated by multivariate logistic regression analysis, four factors—male gender, hypertension, BMI, and current smoking—significantly correlated.Conclusion
The analysis of Kumamoto citizens aged 40–74 years receiving specific health checkups showed that in addition to hypertension and age that were considered important, male gender and obesity are also risk factors for NS/IS independent from hypertension. 相似文献22.
Yushi Nakayama Hiroshi Nonoguchi Shigeru Kiyama Yukimasa Kohda Takeaki Inoue Kimio Tomita 《Hypertension research》2005,28(9):733-739
Angiotensin-converting enzyme inhibitors (ACE-I) have a renoprotective effect in patients with chronic renal failure. Prostaglandins (PGs) have also been shown to ameliorate renal impairment. Although these two have different mechanisms-ACE-I reduces intraglomerular pressure by dilating the efferent arterioles, while it is thought that PGs may increase intraglomerular pressure--coadministration of these drugs may have an additive effect. Administration of a PG with an ACE-I might have an additive effect on chronic renal failure. However, there have been no studies on the efficacy of such a combination therapy. This study was conducted to determine whether combination therapy with PGE1 and an ACE-I might have a long-term benefit on chronic renal failure. Sixty patients with chronic renal disease receiving an ACE-I in advance were assigned to receive an ACE-I alone or an ACE-I plus PGE1. Blood pressure, blood chemistry, urinary protein excretion, and the changes in the reciprocal of serum creatinine (delta1/Cr) were monitored once monthly for an average of 36.5 months. In patients treated only with an ACE-I, the progression of renal failure did not change with time. In contrast, the decline of renal function was significantly reduced with the combination therapy. The renoprotective effect of the combination therapy was not exerted by reduced proteinuria or by decreased blood pressure. PGE1 may reinforce the renoprotective effects of ACE-I to prevent the progression of chronic renal failure. 相似文献
23.
Jun Ueyama Isao Saito Ayuko Takaishi Hiroshi Nomura Mai Inoue Aya Osaka Yuka Sugiura Yumi Hayashi Shinya Wakusawa Hiroko Ogi Kimio Inuzuka Michihiro Kamijima Takaaki Kondo 《Environmental health and preventive medicine》2014,19(6):405-413
Objectives
Biological monitoring of organophosphorus insecticide (OP) metabolites, specifically dialkylphosphates (DAP) in urine, plays a key role in low-level exposure assessment of OP in individuals. The aims of this study are to develop a simple and sensitive method for determining four urinary DAPs using high-performance liquid chromatography with tandem mass spectrometry (LC–MS/MS), and to assess the concentration range of urinary DAP in Japanese children.Methods
Deuterium-labeled DAPs were used as internal standards. Urinary dimethylphosphate (DMP) and diethylphosphate (DEP), which passed through the solid-phase extraction (SPE) column, and dimethylthiophosphate (DMTP) and diethylthiophosphate (DETP), which were extracted from a SPE column using 2.5 % NH3 water including 50 % acetonitrile, were prepared for separation analysis. The samples were then injected into LC–MS/MS. The optimized method was applied to spot urine samples from 3-year-old children (109 males and 116 females) living in Aichi Prefecture in Japan.Results
Results from the validation study demonstrated good within- and between-run precisions (<10.7 %) with low detection limits (0.4 for DMP and DMTP, 0.2 for DEP and 0.1 μg/L for DETP). The geometric mean values and detection rates of the urinary DAPs in Japanese children were 14.4 μg/L and 100 % for DMP, 5.3 μg/L and 98 % for DMTP, 5.5 μg/L and 99 % for DEP, and 0.6 μg/L and 80 % for DETP, respectively.Conclusions
The present high-throughput method is simple and reliable, and can thereby further contribute to development of an exposure assessment of OP. The present study is the first to reveal the DAP concentrations in young Japanese children. 相似文献24.
Microarray and FISH‐based genotype–phenotype analysis of 22 Japanese patients with Wolf–Hirschhorn syndrome 下载免费PDF全文
Kenji Shimizu Keiko Wakui Tomoki Kosho Nobuhiko Okamoto Seiji Mizuno Kazuya Itomi Shigeto Hattori Kimio Nishio Osamu Samura Yoshiyuki Kobayashi Yuko Kako Takashi Arai Tsutomu Oh‐ishi Hiroshi Kawame Yoko Narumi Hirofumi Ohashi Yoshimitsu Fukushima 《American journal of medical genetics. Part A》2014,164(3):597-609
25.
An alternative procedure for the creation of an ileal conduit in patients undergoing pelvic exenteration: dextrotransmesenteric location 总被引:1,自引:0,他引:1
Tadashi Hatano Masamichi Hayakawa Yuzo Koyama Kimio Sugaya Tomonori Miyazato Yoshihide Ogawa 《World journal of urology》1998,16(6):410-412
Ileal conduits have long been accepted as a standard method for urinary diversion, but conventional ileal conduits are not
always suitable for patients whose ureters are for the greater part compromised by neoplasm or preoperative irradiation, resulting
in a shortening of the ureters. Bowel migration into the large cavity, which develops after pelvic organ removal, appears
to cause tension on the ureteroileal anastomotic site. Dextrotransmesenteric placement of an ileal conduit may provide easy
access to the shortened ureters without exerting pressure on the anastomosis. We employed this procedure in seven patients
undergoing pelvic exenteration with relatively minimal morbidity. 相似文献
26.
Hitoshi Shinbo Shinji Kageyama Shinsuke Hayami Tomomi Ushiyama Kazuo Suzuki Kimio Fujita Hiroaki Miyajima 《International journal of urology》2001,8(3):144-147
The details are reported of bladder dysfunction in a Japanese boy with adrenoleukodystrophy. He developed gait disturbance at the age of 15 years. Spastic paraparesis progressed from the legs to the hands and brain magnetic resonance imaging showed characteristic degenerative change. Detrusor hyperreflexia was found by a urodynamic study and detrusor-sphincter dyssynergia was also suspected. 相似文献
27.
Kunihiko TERADA Shigeo MURO Tadashi OHARA Akane HARUNA Satoshi MARUMO Megumi KUDO Emiko OGAWA Yuma HOSHINO Toyohiro HIRAI Akio NIIMI Michiaki MISHIMA 《Respirology (Carlton, Vic.)》2009,14(8):1151-1155
Background and objective: The causes of exacerbations in COPD patients are poorly understood. This study examined the association between cough-reflex sensitivity in patients with stable COPD and the frequency of subsequent exacerbations.
Methods: The sampling frame for cases and controls for this study was patients attending a hospital outpatient clinic. cough-reflex sensitivity was evaluated using the log concentration of capsaicin causing five or more coughs (log C5 ). Subsequent COPD exacerbations were identified prospectively via symptom-based diaries over a 12-month period.
Results: The study group comprised 45 COPD subjects and 10 controls. Mean log C5 was lower in the COPD group than in the control group (0.97 (95% confidence interval (CI): 0.76–1.18) versus 1.26 (95% CI: 0.81–1.71), P = 0.095). In the COPD group, log C5 was negatively correlated with serum CRP level ( r = −0.36, P = 0.02) and significantly associated with the exacerbation frequency ( r = −0.38, P = 0.01). Stepwise multiple regression analysis showed that cough-reflex sensitivity was significantly associated with exacerbation frequency ( r 2 = 0.15, P = 0.01).
Conclusions: Hypersensitivity of the cough reflex to inhaled capsaicin might reflect airway inflammation in stable COPD patients, which predisposes to frequent exacerbations. 相似文献
Methods: The sampling frame for cases and controls for this study was patients attending a hospital outpatient clinic. cough-reflex sensitivity was evaluated using the log concentration of capsaicin causing five or more coughs (log C
Results: The study group comprised 45 COPD subjects and 10 controls. Mean log C
Conclusions: Hypersensitivity of the cough reflex to inhaled capsaicin might reflect airway inflammation in stable COPD patients, which predisposes to frequent exacerbations. 相似文献
28.
Kimio Yamashita Makoto Nakashima Saburo Kajita Midori Hiramatsu Norio Ogawa Akitane Mori Mitsumoto Sato 《Psychiatry and clinical neurosciences》1987,41(3):383-385
The present study showed that DN-1417 had a dose-dependent anticonvulsant activity on El mouse seizure. This finding is consistent with other reports using the kindling model of epilepsy. Since both the El mouse and kindling preparations have been regarded as complex partial seizure with secondary generalization, endogenous brain TRH, as well as exogenous TRH, may act as an anticonvulsant substance to such a seizure type of epilepsy. Moreover, this study showed IR-TRH of the El mouse changed significantly in the striatum or hippocampus genetically or postictally without a change in the TRH receptor binding. A transient decrease in hippocampal IR-TRH after convulsion shown in this study may suggest an increased release of TRH during and after the seizure.
Further studies are required to clarify the relationship between a change in the brain TRH system and seizure susceptibility in the El mouse. 相似文献
Further studies are required to clarify the relationship between a change in the brain TRH system and seizure susceptibility in the El mouse. 相似文献
29.
30.
Kandori A Ogata K Watanabe Y Takuma N Tanaka K Murakami M Miyashita T Sasaki N Oka Y 《Pacing and clinical electrophysiology : PACE》2008,31(4):422-431
Background: The magnetocardiogram (MCG) is a promising medical tool for detecting and visualizing abnormal cardiac electrical activation in heart-disease patients. However, there is no large-scale MCG database of healthy subjects, and there is little knowledge of gender- and age-related influences on MCG data.
Methods and Results: We obtained MCG data from 869 subjects (554 men, 315 women) using a conventional 64-channel MCG system, which covers the whole heart. Electrocardiogram (ECG) data were also obtained; 464 people (268 men, 196 women) were identified as a normal group using ECG data. Time intervals (PQ, QRS, QT, and QTc), current distributions (maximum current vector (MCV), and the total current vector (TCV)) of MCG data of the 464 normal subjects were analyzed to obtain basic MCG parameters.
Although mean values of PQ and QRS intervals of the male subjects were slightly longer than those of the female subjects, no intervals were correlated with gender or age. The correlation between PQ intervals of ECG and those of MCG was better than the correlation between QRS and QT intervals of ECG and those of MCG. Both MCV and TCV angles were much smaller than the electrical-axis angle in ECG. Although TCVs of the QRS and T waves were stable, the women's mean T-wave-TCV angles significantly increased with age. The maximum amplitude of the P wave was about 1.7 pT, and the value of the QRS complex was about 20–25 pT. Moreover, the T-wave amplitude decreases with age.
Conclusion: The MCG standard space-time parameters determined here provide a normal range for MCG parameters. 相似文献
Methods and Results: We obtained MCG data from 869 subjects (554 men, 315 women) using a conventional 64-channel MCG system, which covers the whole heart. Electrocardiogram (ECG) data were also obtained; 464 people (268 men, 196 women) were identified as a normal group using ECG data. Time intervals (PQ, QRS, QT, and QTc), current distributions (maximum current vector (MCV), and the total current vector (TCV)) of MCG data of the 464 normal subjects were analyzed to obtain basic MCG parameters.
Although mean values of PQ and QRS intervals of the male subjects were slightly longer than those of the female subjects, no intervals were correlated with gender or age. The correlation between PQ intervals of ECG and those of MCG was better than the correlation between QRS and QT intervals of ECG and those of MCG. Both MCV and TCV angles were much smaller than the electrical-axis angle in ECG. Although TCVs of the QRS and T waves were stable, the women's mean T-wave-TCV angles significantly increased with age. The maximum amplitude of the P wave was about 1.7 pT, and the value of the QRS complex was about 20–25 pT. Moreover, the T-wave amplitude decreases with age.
Conclusion: The MCG standard space-time parameters determined here provide a normal range for MCG parameters. 相似文献