全文获取类型
收费全文 | 942篇 |
免费 | 91篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 185篇 |
妇产科学 | 67篇 |
基础医学 | 57篇 |
口腔科学 | 13篇 |
临床医学 | 295篇 |
内科学 | 106篇 |
皮肤病学 | 34篇 |
神经病学 | 42篇 |
外科学 | 71篇 |
综合类 | 3篇 |
一般理论 | 10篇 |
预防医学 | 100篇 |
眼科学 | 4篇 |
药学 | 27篇 |
肿瘤学 | 19篇 |
出版年
2020年 | 9篇 |
2018年 | 16篇 |
2017年 | 18篇 |
2016年 | 27篇 |
2015年 | 31篇 |
2014年 | 24篇 |
2013年 | 39篇 |
2012年 | 11篇 |
2011年 | 24篇 |
2010年 | 30篇 |
2009年 | 55篇 |
2008年 | 24篇 |
2007年 | 20篇 |
2006年 | 24篇 |
2005年 | 20篇 |
2004年 | 12篇 |
2003年 | 13篇 |
2002年 | 10篇 |
2001年 | 11篇 |
2000年 | 9篇 |
1999年 | 15篇 |
1998年 | 26篇 |
1997年 | 29篇 |
1996年 | 41篇 |
1995年 | 22篇 |
1994年 | 18篇 |
1993年 | 19篇 |
1992年 | 23篇 |
1991年 | 20篇 |
1990年 | 19篇 |
1989年 | 19篇 |
1988年 | 24篇 |
1987年 | 16篇 |
1986年 | 13篇 |
1985年 | 24篇 |
1984年 | 17篇 |
1982年 | 11篇 |
1981年 | 19篇 |
1980年 | 8篇 |
1979年 | 10篇 |
1978年 | 11篇 |
1977年 | 8篇 |
1976年 | 13篇 |
1975年 | 12篇 |
1974年 | 11篇 |
1973年 | 13篇 |
1972年 | 10篇 |
1971年 | 13篇 |
1961年 | 8篇 |
1958年 | 10篇 |
排序方式: 共有1034条查询结果,搜索用时 15 毫秒
21.
Time-lapse photography was used to examine the effects of γ-aminobutyric acid (GABA) on the outgrowth and motility of neurites in cultures from mouse spinal cord. GABA at concentrations of 100, 10 and 1 μ m caused significant inhibition of neurite outgrowth and the motility of growth cones was significantly reduced by treatment with 100 and 10 μ m GABA. This effect was mimicked by the GABAB receptor agonist baclofen, whereas the GABAA receptor agonist muscimol had no effect. The effect of GABA on outgrowth and motility seems to be dependent on the type of serum employed. The results reported here were obtained only when heat-inactivated serum was used and not when non heat-inactivated serum was added to the culture medium. They suggest that GABA has a role in the regulation of process outgrowth within the embryonic mouse spinal cord. 相似文献
22.
Delayed Enhancement of Acetaminophen Hepatotoxicity by GeneralAnesthesia Using Diethyl Ether or Halothane. WELLS, P. G., RAMJI,P., AND KU, M. S. W. (1986). Fundam. App. Toxicol 6, 299306.Acetaminophen (Tylenol) is a widely used analgesic/antipyreticdrug which is enzymatically bioactivated, or toxified, by thecytochromes P-450 to a hepatotoxic reactive intermediary metabolite.Brief general anesthesia with diethyl ether has been shown toinhibit both the toxifying cytochromes P-450 and enzymatic glucuronidation,the latter constituting up to 60% of acetaminophen eliminationvia a nontoxifying pathway. Thus ether potentially could producea temporally differentiated inhibition of bioactivating and"detoxifying" pathways, resulting in an enhancement of acetaminophenhepatotoxicity if the balance favored bioactivation. To evaluatethis possibility, separate groups of male NIH strain mice weretreated with acetaminophen at different times after 5 min ofanesthesia with ether. Ether produced a 40-fold enhancementin acetaminophen hepatotoxicity as determined by plasma glutamic-pyruvictransaminase (GPT) concentrations. This toxicologic enhancementwas observed only if acetaminophen administration was delayed,with a maximal enhancement when acetaminophen was given 6 hrafter ether, and no effect with a delay of 16 hr. Similar studiesin male CD-1 mice were carried out using halothane (Fluothane)as the general anesthetic given either over 5 min or over 1hr. While halothane given over 5 min had no effect, a 1 hr anestheticduration produced a 10-fold increase in acetaminophen hepatotoxicityas determined by peak GPT concentration, with no observed hepatotoxicityin the halothane controls. Toxicologic enhancement occurredonly with delayed administration of acetaminophen; however,the maximal enhancement observed with a 6-hr delay was stillevident with a 12-hr delay. Conversely, inhibition of acetaminophenhepatotoxicity was observed if acetaminophen was given either2 hr or 18 hr after halothane. These observations may have clinicalrelevance, and they indicate potential complications in theinterpretation of results obtained from animals subjected togeneral anesthesia. 相似文献
23.
R.BRIAN HAYNES PhD PENNY KRIS-ETHERTON PhD RD DAVID A McCARRON MD SUZANNE OPARIL MD ALAN CHAIT MD LAWRENCE M RESNICK MD CYNTHIA D MORRIS PhD SHARON CLARK PhD DANIEL C HATTON PhD JILL A METZ PhD MARGARET McMAHON MN SCOTT HOLCOMB MS GEOFFREY W SNYDER MS F.XAVIER PI-SUNYER MD JUDITH S STERN ScD RD 《Journal of the American Dietetic Association》1999,99(9):1077-1083
24.
Sharon R. Classen RNC MN Pamela R. Paulson RN MS CPNP Sarah R. Zacharias RN MSN CCRN 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1998,27(5):493-500
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can affect almost all organ systems in the body. It is most common in women of childbearing age and may cause multiple peripartum complications. This article reviews the pathophysiology of SLE and the effects of SLE on fertility and pregnancy. The complexities of managing a pregnant patient with SLE are reviewed, and the importance of interdisciplinary collaboration discussed, as well as the effects of SLE on the fetus and a review of neonatal lupus erythematosus. Finally, a case report of a pregnant patient with SLE with challenging clinical management issues is presented. 相似文献
25.
26.
27.
Carol Dawson-Rose PhD Deena Shehadeh MSN RN-BC PHN Jennifer Hao BA Jasmine Barnard BA Ladan Khoddam-Khorasani MPH Adam Leonard MS MPH CPNP AAHIVS Kristen Clark MSN RN Eva Kersey BA Haley Mousseau MA Julie Frank LCSW MSW Aaron Miller PMHNP Adam Carrico PhD Amy Schustack EdD Yvette P. Cuca PhD 《Public health nursing (Boston, Mass.)》2020,37(3):363-370
28.
A functional and clinical reinterpretation of human perineal neuromuscular anatomy: Application to sexual function and continence
下载免费PDF全文
![点击此处可从《Clinical anatomy (New York, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
JEFFREY H. PLOCHOCKI JOSE R. RODRIGUEZ‐SOSA BRENT ADRIAN SAUL A. RUIZ MARGARET I. HALL 《Clinical anatomy (New York, N.Y.)》2016,29(8):1053-1058
Modern anatomical and surgical references illustrate perineal muscles all innervated by branches of the pudendal nerve but still organized into anatomically distinct urogenital and anal triangles with muscles inserting onto a central perineal body. However, these conflict with the anatomy commonly encountered during dissection. We used dissections of 43 human cadavers to characterize the anatomical organization of the human perineum and compare our findings to standard references. We found bulbospongiosus and the superficial portion of the external anal sphincter (EAS) were continuous anatomically with a common innervation in 92.3% of specimens. The superficial transverse perineal muscle inserted anterior and lateral to the midline, interdigitating with bulbospongiosus. The three EAS subdivisions were anatomically discontinuous. Additionally, in 89.2% of our sample the inferior rectal nerve emerged as a branch of S3 and S4 distinct from the pudendal nerve and innervated only the subcutaneous EAS. Branches of the perineal nerve innervated bulbospongiosus and the superficial EAS and nerve to levator ani innervated the deep EAS. In conclusion, we empirically demonstrate important and clinically relevant differences with perineal anatomy commonly described in standard texts. First, independent innervation to the three portions of EAS suggests the potential for functional independence. Second, neuromuscular continuity between bulbospongiosus and superficial EAS suggests the possibility of shared or overlapping function of the urogenital and anal triangles. Clin. Anat. 29:1053–1058, 2016. © 2016 Wiley Periodicals, Inc. 相似文献
29.
30.
MARGARET WANDERA JOSEPHINE KAYONDO INGUNN MARIE S. ENGEBRETSEN ISAAC OKULLO & ANNE NORDREHAUG ÅSTRØM 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2009,19(4):251-262
Background. The impact of oral diseases on quality of life of children and their families has not been thoroughly investigated.
Aim. Focusing on Ugandan infants aged 6–36 months and their caregivers, this study examined the degree to which clinical and psychosocial factors were associated with caregivers' overall evaluation of their children's oral health and health status.
Design. Eight hundred and sixteen children were examined for dental caries and anthropometric status in 2007. A questionnaire was completed by the caregivers.
Results. Poor child oral health was reported by 40.2% and 17.5% of caregivers who reported their children's health as, respectively, poor and good. Having the least family wealth [odds ratio (OR) = 1.9] and reporting distressed family activities (OR = 2.3) were associated with higher odds of reporting poor child oral health, whereas being a rural resident (OR = 0.4) and reporting no symptoms during tooth eruption (OR = 0.3) were associated with lower odds. Perception of poor child oral health (OR = 2.8) and having the least family wealth (OR = 1.7) were associated with higher odds of reporting poor child health status, whereas no stunting was associated with lower odds (OR = 0.5).
Conclusion. The results support the growing recognition of oral health as a predictor of health and well-being in early childhood. 相似文献
Aim. Focusing on Ugandan infants aged 6–36 months and their caregivers, this study examined the degree to which clinical and psychosocial factors were associated with caregivers' overall evaluation of their children's oral health and health status.
Design. Eight hundred and sixteen children were examined for dental caries and anthropometric status in 2007. A questionnaire was completed by the caregivers.
Results. Poor child oral health was reported by 40.2% and 17.5% of caregivers who reported their children's health as, respectively, poor and good. Having the least family wealth [odds ratio (OR) = 1.9] and reporting distressed family activities (OR = 2.3) were associated with higher odds of reporting poor child oral health, whereas being a rural resident (OR = 0.4) and reporting no symptoms during tooth eruption (OR = 0.3) were associated with lower odds. Perception of poor child oral health (OR = 2.8) and having the least family wealth (OR = 1.7) were associated with higher odds of reporting poor child health status, whereas no stunting was associated with lower odds (OR = 0.5).
Conclusion. The results support the growing recognition of oral health as a predictor of health and well-being in early childhood. 相似文献