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881.
Yih-Ru Wu I-Hsin Feng Rong-Kuo Lyu Kuo-Hsuan Chang Yu-Yun Lin Huiling Chan Fen-Ju Hu Guey-Jen Lee-Chen Chiung-Mei Chen 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2007,(3):300-304
Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case-control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor-alpha (TNF-alpha) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T-1031C and C-857T sites showed significant difference between PD cases and controls (P = 0.0062 and 0.0035, respectively). However, only the more frequent -1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.96; 95% CI: 1.38-7.09). Pairwise SNP linkage disequilibrium showed -1031 and -863 sites are in strong linkage disequilibrium (D' = 0.93, Delta(2) = 0.80). Pairwise haplotype analysis among the four sites showed that -1031C-863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33-3.69). 相似文献
882.
目的 探讨游离带感觉神经腹壁下动脉穿支皮瓣移植再造乳房的方法和效果。方法 回顾性研究。纳入2015年10月—2017年12月湖南省肿瘤医院单侧早期(Ⅰ/Ⅱ期)乳腺癌患者12例,均为女性,年龄33~52 (37.4±3.5)岁。12例均行改良根治术,并应用带感觉神经腹壁下动脉穿支皮瓣行同期乳房再造术,皮瓣携带的肋间神经感觉支与受区肋间神经吻合,腹壁下血管与受区胸廓内血管或者胸背血管吻合。记录皮瓣长度、宽度、厚度及血管蒂情况,携带感觉神经长度及选择的受区血管和神经。随访再造乳房的感觉恢复情况,将乳房分为5个区,包括4个象限和中央区,对每区的压力觉和温度觉恢复情况进行记录。完成患者主观感觉的问卷调查,内容包括外形恢复、感觉恢复和满意度。结果 皮瓣长(32.3±0.4)cm、宽(12.7±1.6)cm、厚(3.8±0.4)cm,腹壁下血管蒂长度为(12.5±0.4)cm,动脉管径为(1.7±0.4)mm,伴行静脉管径为(2.2±0.7)mm,携带肋间神经感觉支长度为(2.3±0.4)cm。受区血管为胸廓内血管(7例)和胸背血管(5例)。所有受区神经为同侧第3肋间神经。所有皮瓣顺利成活,1例皮瓣供区发生脂肪液化,经换药后愈合,未见其他并发症。再造乳房外形圆润,弹性质地可,未见皮瓣发生溃疡;皮瓣供区仅遗留线性瘢痕,腹壁功能未见影响。12例患者均获随访12~38个月,平均19.6个月,未见乳腺癌复发情况。术后12个月调查患者的感觉恢复效果,12例(100%)带感觉神经腹壁下动脉穿支皮瓣再造乳房病例中,所有再造乳房至少有1区恢复了温度觉。患者对再造乳房外形及感觉恢复均满意。结论 游离带感觉神经腹壁下动脉穿支皮瓣与受区胸壁第3肋间神经吻合有助于乳腺癌术后乳房再造的感觉功能恢复。 相似文献
883.
Longsheng Ren Jie Zhang Ruiying Guo Can Lyu Danyang Zhao Zhihao Dong Zenglin He Qiang Wang 《Medicine》2022,101(3)
Background:The incidence of acute mastitis (AM) in lactating women has been increasing year by year. If there is no timely and appropriate treatment, AM may develop into mammary abscess and septicemia. This special situation has aroused social attention. Chinese massage has been widely used in the treatment of AM in recent years, but there is no systematic review of the effect of Chinese massage on AM. We plan to explore the efficacy and safety of Chinese massage in the treatment of AM.Methods:We will use a computer to search the following 8 electronic databases (PubMed, Web of Science, Cochrane, Embase, Sinomed, China National Knowledge Infrastructure, Chongqing VIP Information, WanFang Data) on November 30, 2021. Randomized controlled trials (RCT) of Chinese massage therapy for AM were screened. Primary outcome measure: overall clinical response rate, breast pain score. Secondary outcome measures: milk secretion, temperature, mass size and time to resolution, White blood cell count, C-reactive protein, and the incidence of adverse reactions. According to the inclusion criteria and exclusion criteria, the included literature will be independently evaluated by two researchers using the RCT bias risk assessment tool in the Cochrane evaluation manual Handbook5.4, and meta-analysis will be performed by RevMan5.4 software. Funnel plots were used to analyze whether the study had publication bias.Results:We will evaluate the clinical effect of Chinese massage therapy on AM based on RCTsConclusion:This study will provide evidence-based evidence for the effectiveness and safety of Chinese massage in the treatment of AM.Protocol registration number:INPLASY2021120019. 相似文献
884.
885.
886.
Zhang Wan-Lin Dong Zhe Zhang Jun-Yan Lyu Min-Zhi Zhang Wei Huang Jian-Lei Yang Xin 《生殖与发育医学(英文)》2021,(3):156-160
This study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone ... 相似文献
887.
Yi Zhang Shirong Li Zhi Lyu Jinghuang Cai Naishan Zheng Yanping Li Tianwen Xu Huiqing Zeng 《Journal of thoracic disease》2022,14(1):185
BackgroundLung cancer is the leading cause of cancer mortality in China. The clinicopathologic features and genetic profile of Chinese lung cancer patients need to be investigated. This study evaluated the gene mutation profile, analyzed the frequency of concurrent genes in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients, and determined its prognostic value.MethodsWe collected the clinical data from 151 initially diagnosed patients NSCLC. Tumor samples underwent targeted next-generation sequencing (NGS). Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method.ResultsAmong the 151 participants, the mutational profile revealed alterations in 29 genes, where TP53 (37.09%) and EGFR (30.46%) exhibited the highest mutation rates. Mutations in the EGFR gene were most prevalent (40%) in adenocarcinoma (LUAD) and were only present in 8.8% of participants with squamous cell carcinoma (LUSC). The most frequently mutated genes in LUAD patients were TP53 (47%), followed by KRAS (11.7%). In all 39 participants with EGFR mutations, TP53, KRAS, PIK3CA, APC, and FBXW7 were also mutated. Those with only EGFR mutation appeared to have a better prognosis; however, the difference was not statistically significant. Tumor mutational burden (TMB) was roughly significantly increased in patients who harbored EGFR and other mutant driver genes, compared with only EGFR mutant patients. The TMB value was significantly higher in those with P53 mutation than in P53 wild-type patients.ConclusionsWe described the genetic profiles of NSCLC and compared the difference in genetic profiles between LUAD and LUSC. The concomitant genetic alterations might be a poor prognostic factor for patients with EGFR mutation, and TMB might be prognostically related to the co-mutations of EGFR and other genes. 相似文献
888.
Guosheng Lyu Peng Su Xiaohe Hao Shiming Chen Shuai Ren Zixiao Zhao Yaoqin Gong Qiao Liu Changshun Shao 《癌症生物学与医学(英文版)》2021,(1):120-138
Objective:RECQL4(a member of the RECQ helicase family)upregulation has been reported to be associated with tumor progression in several malignancies.However,whether RECQL4 sustains esophageal squamous cell carcinoma(ESCC)has not been elucidated.In this study,we determined the functional role for RECQL4 in ESCC progression.Methods:RECQL4 expression in clinical samples of ESCC was examined by immunohistochemistry.Cell proliferation,cellular senescence,the epithelial-mesenchymal transition(EMT),DNA damage,and reactive oxygen species in ESCC cell lines with RECQL4 depletion or overexpression were analyzed.The levels of proteins involved in the DNA damage response(DDR),cell cycle progression,survival,and the EMT were determined by Western blot analyses.Results:RECQL4 was highly expressed in tumor tissues when compared to adjacent non-tumor tissues in ESCC(P<0.001)and positively correlated with poor differentiation(P=0.011),enhanced invasion(P=0.033),and metastasis(P=0.048).RECQL4 was positively associated with proliferation and migration in ESCC cells.Depletion of RECQL4 also inhibited growth of tumor xenografts in vivo.RECQL4 depletion induced G0/G1 phase arrest and cellular senescence.Importantly,the levels of DNA damage and reactive oxygen species were increased when RECQL4 was depleted.DDR,as measured by the activation of ATM,ATR,CHK1,and CHK2,was impaired.RECQL4 was also shown to promote the activation of AKT,ERK,and NF-k B in ESCC cells.Conclusions:The results indicated that RECQL4 was highly expressed in ESCC and played critical roles in the regulation of DDR,redox homeostasis,and cell survival. 相似文献
889.
Initially, zolpidem, a non-benzodiazepine hypnotic agent, was considered to have fewer adverse reactions than traditional benzodiazepines. However, after zolpidem was approved for medical use, an increasing number of case reports have described abuse or dependence complications. We were especially interested in the cases of dependence that presented a paradoxical ‘euphoric’ effect of zolpidem. This article reports the case of a female zolpidem-dependent patient who presented with 6 years of daily use of 400–1400 mg of zolpidem. She reported subjective effects of euphoria, intense craving and the inability to stop drug ingestion. Her diagnoses were zolpidem dependence and a depressive episode induced by substance abuse. To explore the neural mechanisms of the euphoric effect caused by high-dose zolpidem, we performed repeated magnetoencephalography (MEG) recordings. Before undergoing detoxification, her MEG results indicated that cerebellar electrical signal activation increased when taking high zolpidem doses. However, the prefrontal and parietal lobes’ electrical signal activity showed a tendency to recover to a normal state as the withdrawal time progressed to completion. This case suggests that the cerebellum plays a role in the euphoria induced by high zolpidem doses and provides clues for further research. 相似文献
890.