全文获取类型
收费全文 | 975篇 |
免费 | 46篇 |
国内免费 | 90篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 57篇 |
妇产科学 | 14篇 |
基础医学 | 100篇 |
口腔科学 | 19篇 |
临床医学 | 221篇 |
内科学 | 210篇 |
皮肤病学 | 77篇 |
神经病学 | 32篇 |
特种医学 | 76篇 |
外科学 | 95篇 |
综合类 | 62篇 |
预防医学 | 33篇 |
眼科学 | 8篇 |
药学 | 76篇 |
中国医学 | 3篇 |
肿瘤学 | 26篇 |
出版年
2019年 | 8篇 |
2018年 | 8篇 |
2017年 | 13篇 |
2016年 | 9篇 |
2015年 | 11篇 |
2014年 | 24篇 |
2013年 | 30篇 |
2012年 | 10篇 |
2011年 | 13篇 |
2010年 | 34篇 |
2009年 | 22篇 |
2008年 | 11篇 |
2007年 | 60篇 |
2006年 | 15篇 |
2005年 | 23篇 |
2004年 | 13篇 |
2003年 | 15篇 |
2002年 | 15篇 |
2001年 | 22篇 |
2000年 | 18篇 |
1999年 | 18篇 |
1998年 | 38篇 |
1997年 | 51篇 |
1996年 | 35篇 |
1995年 | 40篇 |
1994年 | 36篇 |
1993年 | 29篇 |
1992年 | 17篇 |
1991年 | 10篇 |
1990年 | 26篇 |
1989年 | 35篇 |
1988年 | 22篇 |
1987年 | 18篇 |
1986年 | 18篇 |
1985年 | 14篇 |
1984年 | 9篇 |
1983年 | 12篇 |
1982年 | 11篇 |
1981年 | 14篇 |
1977年 | 11篇 |
1976年 | 13篇 |
1975年 | 8篇 |
1968年 | 8篇 |
1966年 | 10篇 |
1965年 | 12篇 |
1963年 | 11篇 |
1959年 | 13篇 |
1958年 | 7篇 |
1956年 | 8篇 |
1936年 | 7篇 |
排序方式: 共有1111条查询结果,搜索用时 15 毫秒
51.
52.
M T Lucking 《Physiotherapy》1966,52(12):420-424
53.
54.
CH Walker 《Archives of disease in childhood》1977,52(6):452-461
55.
Professor C. Kaplan MSC MB CH.B FRC.PATH 《International journal of clinical practice》1976,30(11-12):208-211
56.
Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: Implications for clinical studies 总被引:3,自引:0,他引:3
G.?Aernout?SomsenEmail author Hein?J.?Verberne Eric?Fleury Alberto?Righetti 《Journal of nuclear cardiology》2004,11(2):126-133
BACKGROUND: Although several myocardial iodine 123 metaiodobenzylguanidine (MIBG) indices are increasingly used to detect alterations in myocardial sympathetic activity in various forms of cardiac pathology, published measurements of normal values and within-subject variability are lacking. METHODS AND RESULTS: Twenty-five healthy volunteers underwent planar and single photon emission computed tomography (SPECT) imaging. Heart-mediastinum ratio (H/M) and myocardial washout were calculated from planar images comparing three different methods for the assessment of myocardial activity: (1) global region over the myocardium (cavity included), (2) global region over the myocardium (cavity excluded), and (3) fixed small myocardial region. Segmental (relative) uptake and washout were assessed by SPECT. For all MIBG indices, the interindividual variation was the lowest for methods 1 and 2. In SPECT this variation was low for relative segmental uptake compared with washout. In 9 subjects a second MIBG scintigraphy was performed after 3 months. The within-subject variability of H/M and washout assessed by planar methods 1 and 2 was 5%, whereas it was approximately 9% for planar method 3. For relative segmental uptake from SPECT, this variability was 5%. CONCLUSION: MIBG H/M (planar) and relative segmental uptake (SPECT) show a low interindividual and within-subject variability. This enables the detection of small (regional) variations in myocardial sympathetic nervous function, especially to monitor the effect of therapeutic interventions in patients with various cardiac diseases. 相似文献
57.
A randomised controlled trial of epidural compared with non-epidural analgesia in labour 总被引:2,自引:1,他引:1
Howell CJ Kidd C Roberts W Upton P Lucking L Jones PW Johanson RB 《BJOG : an international journal of obstetrics and gynaecology》2001,108(1):27-33
Objectives To investigate possible short and long term side effects of epidural analgesia, compared with non-epidural analgesia for pain relief in labour.
Design Randomised controlled study, with long term follow up by questionnaire. Analysis by intention-to-treat.
Setting Busy maternity unit within a district general hospital in England.
Participants Three hundred and sixty nine primigravid women in labour were included (randomised allocation: epidural n = 184 , non-epidural n = 185 ).
Main outcome measures Backache at three and twelve months after delivery, instrumental delivery rates and maternal opinion of pain relief in labour.
Results No significant differences were found in the reported incidence of backache between the groups at three months: middle backache [ 22% vs 20%, χ2 = 0.057, P = 0.81; odds ratio (95% CI) 1.4(0.9-2.3) ]; low backache [ 35% vs 34%, χ 2 = 0.009, P = 0.92 ; odds ratio (95% CI) 1.0(0.6-1.6) ]. Nor were there significant differences at 12 months: [middle backache 16% vs 16%, χ 2 = 0.013, P = 0.91; odds ratio (95% CI) 1.0(0.5-1.8) ]; or low backache [ 35% vs 27%, χ 2 = 1.91, P = 0.17; odds ratio (95% CI) 1.4(0.9-2.3) ]. The incidence of instrumental delivery was somewhat higher in the epidural group [30% vs 19%, odds ratio (95% CI) 1.77 (1.09-2.86)]. Maternal satisfaction was not significantly different between the groups.
Conclusions This study provided no evidence to support the suggestion of a direct association between the use of epidural anaesthesia in labour and the incidence of long term backache. Despite a significant proportion of women in each group not receiving their allocated analgesia, a significant difference in terms of instrumental delivery rates remained. Satisfaction in both groups of women was high. 相似文献
Design Randomised controlled study, with long term follow up by questionnaire. Analysis by intention-to-treat.
Setting Busy maternity unit within a district general hospital in England.
Participants Three hundred and sixty nine primigravid women in labour were included (randomised allocation: epidural n = 184 , non-epidural n = 185 ).
Main outcome measures Backache at three and twelve months after delivery, instrumental delivery rates and maternal opinion of pain relief in labour.
Results No significant differences were found in the reported incidence of backache between the groups at three months: middle backache [ 22% vs 20%, χ
Conclusions This study provided no evidence to support the suggestion of a direct association between the use of epidural anaesthesia in labour and the incidence of long term backache. Despite a significant proportion of women in each group not receiving their allocated analgesia, a significant difference in terms of instrumental delivery rates remained. Satisfaction in both groups of women was high. 相似文献
58.
4分子治疗分析肿瘤细胞中的分子遗传性变异及后天变异的方法正在快速成熟起来。这些方法通常涉及基因组学、转录特征性识别及蛋白质组学,有利于更深入地了解ALL的发病机理,使用于临床评估的靶向治疗全面发展。最终,这些层出不穷的新技术将营造出一个全新的个性化分子医学时代,创造出效果更好而毒性更低的治疗方案。尽管治疗方案均显示了药物介入控制细胞周期进程、基因转录、细胞运动、凋亡及细胞代谢信号通路的可行性(图1),但针对ALL的分子治疗情况(表1)仍差强人意。我们将从众多正处于临床前期或早期临床研究的分子治疗方案中,选择出那… 相似文献
59.
利用目前的治疗手段,80%的急性淋巴细胞白血病(acute lymphoblastic leukem ia,ALL)患儿均能得到治愈,尚有部分患者需接受强化治疗,但治疗的副作用也带来了急性或远期的严重并发症。此外,成人ALL病人的生存率依然低于40%。因此,本病需要既可以提高治愈率又能改善生活质量的新治疗方案。本文讨论了新出现的可能会改善ALL病人预后的治疗方法,包括现有常规化疗药物的新剂型、新的抗代谢药和核苷衍生物、白血病相关抗原的单克隆抗体,针对白血病细胞的基因异常及相关信号通路的分子治疗。1常规化疗药物的新剂型化疗药物的脂质体剂型是将药物… 相似文献
60.
N. MATSANIOTIS F. TZORTZATOU-STATHOPOULOU TH. THOMAIDIS Z. KARAKATSANI-KERASIOT CH. THEODORIDIS C. DACOU-VOUTETAKIS 《Acta paediatrica (Oslo, Norway : 1992)》1981,70(6):949-950
Abstract. Matsaniotis, N., Tzortzatou-Stathopoulou, F., Thomaidis, Th., Karakatsani-Kerasioti, Z., Theodoridis, Ch. and Dacou-Voutetakis, C. (First Department of Paediatrics of Athens University, "Aghia Sophia" Children's Hospital, Athens, Greece). Diabetes mellitus and Addison's disease in an adolescent female. Acta Paediatr Scand, 70: 949, 1981.-This short report describes a 16-year-old female who presented with Addison's disease 6 years after diabetes mellitus had been diagnosed. The possibility of both conditions being present should be borne in mind whenever an unexplained reduction of insulin requirements is noted, especially if this is accompanied by cutaneous pigmentation. The metabolic interrelationships of the two conditions are briefly discussed. 相似文献