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Journal of Neurology - The non-motor features of Parkinson’s disease (PD) are increasingly being recognised. This review deals with the spectrum of sleep disorders associated with PD, which... 相似文献
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Yan Sun PhD Sameer C. Dhamne MS Alejandro Carretero-Guillén PhD Ricardo Salvador PhD Marti C. Goldenberg BS Brianna R. Godlewski BS Alvaro Pascual-Leone MD PhD Joseph R. Madsen MD Scellig S. D. Stone MD PhD Giulio Ruffini PhD Javier Márquez-Ruiz PhD Alexander Rotenberg MD PhD 《Annals of neurology》2020,88(3):489-502
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Katherine Julian BS Nicholas Yuhasz BS Widjan Rai MD Jose A. Salerno BS Jaime Imitola MD 《Annals of neurology》2020,88(4):661-668
“Stem cell tourism,” the practice of offering unproven cellular preparations to patients as approved therapy, is rising in neurology. Currently, the experiences of patients and reported complications from these procedures are unknown in the United States. We evaluate academic neurologists' experiences with stem cell tourism and assess perceived competency on discussing this topic with patients. We found a lack of neurologist preparedness to discuss stem cell therapies with patients and an alarming list of unreported complications from these unregulated procedures. We also identified an urgent need for neurologist education and the creation of a national registry for reporting patient complications resulting from experimental stem cell interventions. ANN NEUROL 2020;88:661–668 相似文献
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Yoshio Okada PhD Sheraz Khan PhD Ashley Curran BS Banu Ahtam DPhil Matti S. Hämäläinen DSc Roger D. Traub MD Phillip L. Pearl MD 《Annals of neurology》2020,88(2):418-422
Neoplastic or dysplastic neuronal tissue in the brain stem and cerebellum can become epileptogenic in pediatric patients. However, it is unknown whether such tissue may transform intrinsic properties of the human cerebellum, making it capable of generating epileptic population activity. We noninvasively detected epileptiform signals unaveraged in a pediatric patient with epilepsy due to a tumor in the middle cerebellar peduncle. Analysis of generators of the signals revealed that the cerebellum ipsilateral and contralateral to the tumor was the dominant interictal spike generator and could initiate ictal activity, suggesting that human cerebellum may become capable of intrinsically generating epileptic activity. ANN NEUROL 2020;88:418–422. 相似文献
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Alma Ghirelli MD Nirubol Tosakulwong BS Stephen D. Weigand MS Heather M. Clark PhD Farwa Ali MD Hugo Botha MD Joseph R. Duffy PhD Rene L. Utianski PhD Marina Buciuc MD Melissa E. Murray PhD Sydney A. Labuzan MS Anthony J. Spychalla BS Nha Trang Thu Pham BS Christopher G. Schwarz PhD Matthew L. Senjem MS Mary M. Machulda PhD Matthew Baker BS Rosa Rademakers PhD Massimo Filippi MD Clifford R. Jack Jr MD Val J. Lowe MD Joseph E. Parisi MD Dennis W. Dickson MD Keith A. Josephs MD MST MSc Jennifer L. Whitwell PhD 《Annals of neurology》2020,88(5):1009-1022
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Seasonal patterns in flu transmission have observational validity in temperate climates. However, there is no consensus mechanism explaining the increased incidence of flu during the winter. The physiologic effects of cold weather and dry air on the upper respiratory system may contribute to immune dysfunction and increased susceptibly to flu-causing pathogens. Low temperature limits the absolute humidity of air. Persistent exposure to dry air leads to airway desiccation and failure of the mucociliary system. The resultant physiologic and histopathologic changes that occur in the airway increase susceptibility to flu-causing pathogens. Laryngoscope, 130:309–313, 2020 相似文献