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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
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Linda Reus Ben J. Pelzer Barto J. Otten Elbrich P.C. Siemensma Janielle A.A.E.M. van Alfen-van der Velden Dederieke A.M. Festen Anita C.S. Hokken-Koelega Maria W.G. Nijhuis-van der Sanden 《Research in developmental disabilities》2013,34(10):3092-3103
Although severe motor problems in infants with Prader-Willi syndrome (PWS) are striking, motor development has never been studied longitudinally and the results of growth hormone (GH) treatment on motor development are contradictory. The authors studied whether GH treatment can enhance the effect of physical training on motor development in infants with PWS. Twenty-two infants were followed for two years during a randomized controlled trial. The treatment and control groups began GH after baseline or following a control period, respectively. Both groups followed a child-specific physical training program. Motor performance was measured every three months. Multi-level regression analysis revealed that motor development differed significantly between infants (p < .001), and this could be partially explained by baseline motor developmental level (p < .01). GH treatment enhanced the effects of child-specific physical training on both motor developmental rate and motor developmental potential. Moreover, this effect was more pronounced when GH treatment was initiated at a younger age. 相似文献
955.
Linda Visser Selma A.J. Ruiter Bieuwe F. Van der Meulen Wied A.J.J.M. Ruijssenaars Marieke E. Timmerman 《Research in developmental disabilities》2013,34(11):3736-3745
The aim of the present study was to examine the validity of the Bayley-III Low Motor/Vision version, and its suitability for children with motor and/or visual impairment(s). This version contains accommodated items, that is, adaptations to minimize impairment bias, without altering what the test measures. We hypothesized that the accommodations would not affect the item scores of children without impairment, and that children with impairment(s) would benefit from the accommodations. We tested 41 children without impairment and 63 children with impairment with both the standard Bayley-III and the Low Motor/Vision versions, in randomly counterbalanced order. The test administrators filled in an evaluation form. Results showed that the accommodations did not affect the test scores of children without impairment and did improve the test scores of children with impairment on the Cognition scale, while no improvement was found for the other scales. The test administrators indicated that the vast majority of the children with impairment had been able to show their abilities on the test and that the accommodations were beneficial in 29 out of these 52 cases. For some children, the accommodated instrument appeared to be unsuitable because the impairment was too severe. The conclusion is that the accommodations improve the validity of the Bayley-III when used with children with mild to moderate motor and/or visual impairment, especially with regard to the Cognition scale. 相似文献
956.
Brooke Sinderberry Scott Brown Peter Hammond Angela F. Stevens Ulrich Schall Declan G.M. Murphy Kieran C. Murphy Linda E. Campbell 《Research in developmental disabilities》2013,34(1):116-125
22q11.2 deletion syndrome (22q11DS) has a complex phenotype with more than 180 characteristics, including cardiac anomalies, cleft palate, intellectual disabilities, a typical facial morphology, and mental health problems. However, the variable phenotype makes it difficult to predict clinical outcome, such as the high prevalence of psychosis among adults with 22q11DS (~25–30% vs. ~1% in the general population). The purpose of this study was to investigate whether subtypes exist among people with 22q11DS, with a similar phenotype and an increased risk of developing mental health problems. Physical, cognitive and behavioural data from 50 children and adolescents with 22q11DS were included in a k-means cluster analysis. Two distinct phenotypes were identified: Type-1 presented with a more severe phenotype including significantly impaired verbal memory, lower intellectual and academic ability, as well as statistically significant reduced total brain volume. In addition, we identified a trend effect for reduced temporal grey matter. Type-1 also presented with autism-spectrum traits, whereas Type-2 could be described as having more 22q11DS-typical face morphology, being predominately affected by executive function deficits, but otherwise being relatively high functioning with regard to cognition and behaviour. The confirmation of well-defined subtypes in 22q11DS can lead to better prognostic information enabling early identification of people with 22q11DS at high risk of psychiatric disorders. The identification of subtypes in a group of people with a relatively homogenous genetic deletion such as 22q11DS is also valuable to understand clinical outcomes. 相似文献
957.
Linda Wark 《Journal of family psychotherapy》2013,24(1):89-94
Children can become dysregulated for a wide variety of reasons. This article explains dysregulation and offers two interventions that both parents and therapists can use with young children to improve regulation. Tips for implementing the interventions to their maximum effectiveness are also provided. 相似文献
958.
Abstract This study updates a systematic review of the effectiveness of personal construct psychotherapy and refines a previous meta-analysis by focusing on studies conducted in clinical settings. Twenty-seven studies satisfied the criteria for the systematic review, including 20 in clinical settings. Meta-analysis of the latter provided strong evidence of an advantage of personal construct psychotherapy over a no-treatment control; this benefit was maintained at follow-up. Meta-analysis of studies with an active treatment control group provided no evidence of the superiority or inferiority of personal construct psychotherapy. The available research justifies the practice of personal construct psychotherapy with clients in clinical practice, but conclusions must be tempered by the small number of studies and their methodological shortcomings. 相似文献
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