全文获取类型
收费全文 | 12873篇 |
免费 | 693篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 167篇 |
儿科学 | 287篇 |
妇产科学 | 234篇 |
基础医学 | 1858篇 |
口腔科学 | 1293篇 |
临床医学 | 910篇 |
内科学 | 2687篇 |
皮肤病学 | 310篇 |
神经病学 | 908篇 |
特种医学 | 218篇 |
外科学 | 1321篇 |
综合类 | 52篇 |
一般理论 | 4篇 |
预防医学 | 1493篇 |
眼科学 | 238篇 |
药学 | 1049篇 |
中国医学 | 123篇 |
肿瘤学 | 489篇 |
出版年
2023年 | 125篇 |
2022年 | 297篇 |
2021年 | 518篇 |
2020年 | 328篇 |
2019年 | 427篇 |
2018年 | 539篇 |
2017年 | 341篇 |
2016年 | 387篇 |
2015年 | 413篇 |
2014年 | 606篇 |
2013年 | 659篇 |
2012年 | 1045篇 |
2011年 | 1189篇 |
2010年 | 662篇 |
2009年 | 462篇 |
2008年 | 793篇 |
2007年 | 766篇 |
2006年 | 610篇 |
2005年 | 580篇 |
2004年 | 519篇 |
2003年 | 430篇 |
2002年 | 394篇 |
2001年 | 213篇 |
2000年 | 208篇 |
1999年 | 166篇 |
1998年 | 54篇 |
1997年 | 37篇 |
1996年 | 33篇 |
1995年 | 32篇 |
1994年 | 25篇 |
1993年 | 24篇 |
1992年 | 80篇 |
1991年 | 65篇 |
1990年 | 56篇 |
1989年 | 57篇 |
1988年 | 40篇 |
1987年 | 33篇 |
1986年 | 38篇 |
1985年 | 36篇 |
1984年 | 20篇 |
1983年 | 19篇 |
1979年 | 23篇 |
1978年 | 18篇 |
1977年 | 18篇 |
1974年 | 18篇 |
1973年 | 24篇 |
1972年 | 15篇 |
1970年 | 17篇 |
1969年 | 23篇 |
1967年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
Barreto DF Takiya CM Paes MV Farias-Filho J Pinhão AT Alves AM Costa SM Barth OM 《Journal of submicroscopic cytology and pathology》2004,36(2):121-130
The difficulty in studying dengue virus (DENV) infection in humans and in developing a virus vaccine is the absence of a suitable animal model which develops the full spectra of the Dengue haemorrhagic fever (DHF) and Dengue shock syndrome (DSS). Despite the fact that viruses have been found in various animal tissues, we isolated DENV from tissues of adult BALB/c mice, inoculated with DENV serotype 2 (DENV-2) obtained from human serum. Viruses were ultrastructurally identified and immunolocalized by immunofluorescence techniques in C6/36 mosquito cell cultures, inoculated with tissues (liver, lung, kidney and cerebellum) macerate supernatant from mice, 48 h post-infection (p.i.). These organs, collected at the same stage of infection, were examined histologically. The histopathological analysis revealed focal alterations in all tissues examined. Liver contained focal ballooned hepatocytes, but without modifying the average diameter of the majority of hepatocytes. Sinusoidal lumen was significantly diminished at this stage but portal and centrolobular veins became congested. Lungs exhibited hemorrhagic foci in the alveolar space, vascular congestion and focal alveolitis. Cerebellar tissue showed rare foci of neuronal compactation (Purkinje cells) and perivascular oedema. In kidneys it was observed an increase in glomerular volume with augmented endocapillary and mesangial cellularity, with reactivity to anti-IgM in all glomeruli of infected mice. In conclusion, DENV-2 was found in all tissues examined early in the evolution of infection. Presence of viruses in tissues has mainly led to hemodynamic alterations with generalized vascular congestion and increased permeability, and mast cell recruitment in lungs. The latter could participate in the vascular modifications in tissues. 相似文献
62.
Maria Peres Manuela F. Almeida lia J. Pinto Carla Carmona Sara Rocha Arlindo Guimas Rosa Ribeiro Esmeralda Martins Anabela Bandeira Anita MacDonald Júlio C. Rocha 《Nutrients》2021,13(3)
We aimed to report the implementation of a phenylketonuria (PKU) transition program and study the effects of follow-up with an adult team on metabolic control, adherence, and loss of follow-up. Fifty-five PKU patients were analysed in the study periods (SP): 2 years before (SP1) and after the beginning of adult care (SP2). Retrospective data on metabolic control and number of clinic appointments were collected for each SP, and protein intakes were analysed. In SP2, three patients (6%) were lost to follow-up. There was a small but statistically significant increase in median number of annual blood spots from SP1 to SP2: 11 (7–15) vs. 14 (7–20); p = 0.002. Mean ± SD of median blood Phe remained stable (525 ± 248 µmol/L vs. 552 ± 225 µmol/L; p = 0.100); median % of blood Phe < 480 µmol/L decreased (51 (4–96)% vs. 37 (5–85)%; p = 0.041) and median number of clinic appointments increased from SP1 to SP2: (5 (4–6) vs. 11 (8–13); p < 0.001). No significant differences were found regarding any parameter of protein intake. Our results suggest that the implementation of an adult service was successful as impact on metabolic control was limited and attendance remained high. Continuous dietetic care likely contributed to these results by keeping patients in follow-up and committed to treatment. 相似文献
63.
Anne Daly Wolfgang Hgler Nicola Crabtree Nick Shaw Sharon Evans Alex Pinto Richard Jackson Catherine Ashmore Júlio C. Rocha Boyd J. Strauss Gisela Wilcox William D. Fraser Jonathan C. Y. Tang Anita MacDonald 《Nutrients》2021,13(6)
In patients with phenylketonuria (PKU), treated by diet therapy only, evidence suggests that areal bone mineral density (BMDa) is within the normal clinical reference range but is below the population norm. Aims: To study longitudinal bone density, mass, and geometry over 36 months in children with PKU taking either amino acid (L-AA) or casein glycomacropeptide substitutes (CGMP-AA) as their main protein source. Methodology: A total of 48 subjects completed the study, 19 subjects in the L-AA group (median age 11.1, range 5–16 years) and 29 subjects in the CGMP-AA group (median age 8.3, range 5–16 years). The CGMP-AA was further divided into two groups, CGMP100 (median age 9.2, range 5–16 years) (n = 13), children taking CGMP-AA only and CGMP50 (median age 7.3, range 5–15 years) (n = 16), children taking a combination of CGMP-AA and L-AA. Dual X-ray absorptiometry (DXA) was measured at enrolment and 36 months, peripheral quantitative computer tomography (pQCT) at 36 months only, and serum blood and urine bone turnover markers (BTM) and blood bone biochemistry at enrolment, 6, 12, and 36 months. Results: No statistically significant differences were found between the three groups for DXA outcome parameters, i.e., BMDa (L2–L4 BMDa g/cm2), bone mineral apparent density (L2–L4 BMAD g/cm3) and total body less head BMDa (TBLH g/cm2). All blood biochemistry markers were within the reference ranges, and BTM showed active bone turnover with a trend for BTM to decrease with increasing age. Conclusions: Bone density was clinically normal, although the median z scores were below the population mean. BTM showed active bone turnover and blood biochemistry was within the reference ranges. There appeared to be no advantage to bone density, mass, or geometry from taking a macropeptide-based protein substitute as compared with L-AAs. 相似文献
64.
Nascimento Bruno Andrade Hiury S. Miranda Eduardo P. Barbosa João Arthur Brunhara Alves Moscardi Paulo R. Arap Marco A. Mitre Anuar I. Srougi Miguel Srougi Victor Duarte Ricardo J. 《International urology and nephrology》2021,53(2):269-273
International Urology and Nephrology - To evaluate outcomes of laparoscopic pyeloplasty (LP) in adults with poorly functioning kidney due to ureteropelvic junction obstruction (UPJO). A... 相似文献
65.
Amadio Eliane Martins Marcos Rodrigo Labat Serra Andrey Jorge dos Santos Solange Almeida Caires Jheniphe Rocha Fernandes Guilherme Henrique Cardosos Leal-Junior Ernesto Cesar Ferrari João Carlos Correa de Tarso Camillo de Carvalho Paulo 《Lasers in medical science》2021,36(7):1427-1435
Lasers in Medical Science - Photobiomodulation therapy (PBMT) has been indicated for enforcement on healing skin wounds. This study evaluated the effects of PBMT on the healing of skin wounds... 相似文献
66.
Costa Davidson Ribeiro Pessoa Diego Rodrigues Seefeldt Vanessa Borelli Costa David Ribeiro Maia Daniel Tineu Leite dos Santos Maciel Thiago Mota Brenda Barros Magalhães Delpasso Carolina Alves Ribeiro Camila Alves Delpasso Nicolau Renata Amadei 《Lasers in medical science》2021,36(8):1681-1689
Lasers in Medical Science - This study compared the effects of LED therapy associated with occlusal splint (OS) on the signs and symptoms of temporomandibular disorder (TMD). In this randomized,... 相似文献
67.
Daniela de Queiroz Moura Ramon Rawache Marília Ferreira Gomes Garcia Nathalia Farias Vasconcelos Priscila Santos Gustavo Rego Coelho Thiago Luis da Paz Santos Duílio Reis da Rocha Filho Sonia Leite da Silva Eliana Regia Barbosa de Almeida Paula F.C.B.C. Fernandes João Batista Cerqueira José Huygens Parente Garcia Claudia Maria Costa de Oliveira 《Transplantation proceedings》2021,53(4):1345-1349
Transplantation of any organ has some inherent risk of disease transmission, such as infection and malignancy. The present study aims to describe 2 cases of choriocarcinoma transmission after kidney and liver transplantation originating from the same patient. The donor was a 17-year-old woman who died of cerebral hemorrhage. Both organ recipients died of metastatic choriocarcinoma few months after the transplantation, within days after starting chemotherapy. Retrospective hCG (human chorionic gonadotropin hormone) analysis in donor's blood stored at the time of donation had a result of 9324 mIU/mL. Despite its rarity, clinicians should be aware of the risk of transplant-related choriocarcinoma from female donors in childbearing age. In some cases, hCG dosage should be performed before donation. 相似文献
68.
69.
Adi Lustig Paulo Alves Evan Call Nick Santamaria Amit Gefen 《International wound journal》2021,18(2):194
Wound‐dressing performances are affected by exudate viscosity, resistance to flow because of gravity, and bodyweight loads, the level of which is related to the body position. Here, we focussed on two dressing properties: (a) Sorptivity—the ability of dressings to transfer exudate away from the wound bed by capillary action—and (b) Durability—the capacity of dressings to maintain their integrity over time and during their removal. Both properties are critically important for avoiding further tissue damage but require the development of new laboratory tests for their measurement. A computer‐controlled phantom of an exuding sacral pressure ulcer has therefore been developed and used to compare the performances of Exufiber (Mölnlycke Health Care) vs an alternative market‐leading dressing. Sorptivity was determined using weight tests, and durability was measured through tensile tests of the used dressings. For a supine configuration, the Exufiber dressing demonstrated ~three times higher sorptivity and better durability, withstanding ~five times greater strain energy than the other product before failure occurred. This work paves the way for quantitative, standardised testing of dressings in all aspects of exudate management. The reported tests are further suitable for testing dressing combinations or how dressings interact with negative pressure wound therapy. 相似文献
70.
V. Umansky V. Schirrmacher M. Rocha 《Journal of molecular medicine (Berlin, Germany)》1996,74(7):353-363
The metastatic process is characterized by a complex series of sequential steps involving constant interactions (mutual cross-talks) of metastasized tumor cells with their microenvironment (lymphocyte, macrophages, endothelial cells, etc.) in target organs. These interactions determine the outcome of metastasis (either the eradication of metastatic cells or their increased proliferation and invasion). Recently developed methods of tumor and host cell analysis at the molecular level allow better elucidation of molecular mechanisms of metastasis and of immune mechanisms involved in antitumor responses. Direct modulation of these processes will probably increase the success of clinical cancer treatment. Here we review data (a) on the expression of some costimulatory (MHC class II, CD80, sialoadhesin) and adhesion (LFA1, ICAM-1, VLA-4) molecules on both metastasized tumor cells and host cells and (b) on the production of a cytotoxic molecule, nitric oxide, by in situ activated Kupffer and endothelial cells in the process of liver metastasis. This study was performed with well-characterized murine ESbL T lymphoma cells transduced with the bacterial lacZ gene, which allows detection and quantification of metastases at the single cell level throughout lymphoma growth and metastasis. Experimental results are discussed in the context of recent literature.Abbreviations
APC
Antigen-presenting cells
-
hCRP
Human C-reactive protein
-
ICAM
Intercellular adhesion molecule
-
IFN
Interferon
-
IL
Interleukin
-
iNOS
Inducible NO synthase
-
LFA
Leukocyte function associated antigen
-
SER
Sheep erythrocyte receptor
-
TA
Tumor-associated rejection antigens
-
TNF
Tumor necrosis factor
-
VCAM
Vascular cell adhesion molecule
-
VLA
Very late activated antigen 相似文献