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排序方式: 共有8680条查询结果,搜索用时 29 毫秒
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Neil B. Marya Patrick D. Powers Larissa Fujii-Lau Barham K. Abu Dayyeh Ferga C. Gleeson Shigao Chen Zaiyang Long David M. Hough Vinay Chandrasekhara Prasad G. Iyer Elizabeth Rajan William Sanchez Tarek Sawas Andrew C. Storm Kenneth K. Wang Michael J. Levy 《Gastrointestinal endoscopy》2021,93(5):1121-1130.e1
153.
Levey Elizabeth J. Rondon Marta B. Sanchez Sixto Zhong Qiu-Yue Williams Michelle A. Gelaye Bizu 《Archives of women's mental health》2019,22(1):65-73
Archives of Women's Mental Health - The goals of this research were to characterize suicidal behavior among a cohort of pregnant Peruvian women and identify risk factors for transitions between... 相似文献
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Joanna Romejko-Jarosińska Ewa Paszkiewicz-Kozik Michał Szymczyk Beata Ostrowska Katarzyna Domańska-Czyż Monika Świerkowska-Czeneszew Lidia Popławska Eugeniusz Krzysztof Machaj Jan Walewski 《Acta haematologica Polonica》2012,43(2):210-214
Early non-haematological toxicity of high dose therapy (HDT) and autologous haematopoietic cell transplantation (autoHCT) can be more hazardous in older patients (pts) with comorbidities. The aim of the study was to analyze incidence and grade of the organ-related early complications up to 30 days post-transplant period in elderly lymphoma patients. Between January 2005 and November 2011, 44 consecutive lymphoma pts underwent HDT followed by autoHCT. Median age of pts was 62 years (range 60–67). Conditioning regimens were: BEAM(carmustine, etoposide, cytarabine, melphalan) in 16, melphalan 200 in 22, cytarabine, melphalan or cyclophosphamide – in 6 pts. 32% pts had comorbidities: in 71% cardiovascular. Early non-haematologic complications within 30 days after autoHCT were reported in 84% of pts. The most common events were gastrointestinal (77%): 55% pts had prolonged (more than 7 days) diarrhoea grade III—IV, nausea and vomiting occurred in 40% of pts, 50% of pts demonstrated mucositis (grade III—IV in 34% of pts). Neutropenic fever was reported in 59% of pts with sepsis in 1.9% of pts. Cardiac events occurred in 9% of pts. Median hospitalization was 21 days (range 16—45). One patient died from transplanted related toxicity. HDT resulted in high incidence of non-hematologic toxicity in elderly patients during early post-transplant period. The toxicity of this procedure is acceptable, with mortality rate of only 2% in the elderly transplanted patients. The most common toxicities were: neutropenic fever, gastrointestinal toxicity and cardiac complications 相似文献
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Natália C.C.A Fernandes Juliana S. Nogueira Rodrigo A. Réssio Cinthya S. Cirqueira Lidia M. Kimura Karolina R. Fernandes Mariana S. Cunha Renato P. Souza Juliana M. Guerra 《Experimental and toxicologic pathology》2017,69(2):63-71
A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America, with neurological symptons including meningoencephalitis and Guillain-Barré syndrome in adults, besides an apparent increased incidence of microcephaly in infants born to infected mothers. It is becoming a necessity to have a trustworthy animal model to better understand ZIKV infection. In this study we used newborn white Swiss mice as a model to investigate the ZIKV strain recently isolated in Brazil. ZIKV was inoculated via intracerebral and subcutaneous routes and analysed through gross histopathology and immunohistochemistry. Here we demonstrated first that the intracerebral group (ICG) displayed severe cerebral lesions, with neuronal death, presence of apoptotic bodies, white matter degeneration and neutrophil perivascular cuffing. In the subcutaneous group (SCG), we observed moderate cerebral lesions, morphologically similar to that found in ICG and additional myelopathy, with architectural loss, marked by neuronal death and apoptotic bodies. Interestingly, we found an intense astrogliosis in brain of both groups, with increased immunoexpression of GFAP (glial fibrillary acidic protein) and presence of hypertrophic astrocytes. The spinal cord of subcutaneous group (SCG) exhibited reduction of astrocytes, but those positive for GFAP were hypertrophic and presented prolonged cellular processes. Finally significant lesions in the central nervous system (CNS) were present in newborn mice inoculated by both routes, but SCG method led to an important neurological manifestations (including myelopathy), during a longer period of time and appears for us to be a better model for ZIKV infection. 相似文献
160.