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101.
Lihong Pu Rongjuan Li Jinjie Xie Ya Yang Guowen Liu Yueli Wang Yijia Li 《Ultrasound in medicine & biology》2018,44(4):825-830
The objective of this study was to determine the characteristic echocardiographic manifestations of Behçet's disease. Ninety-seven Behçet's patients admitted to our hospital from January 2002 to December 2016 were retrospectively analyzed. There were 63 patients (64.9%) with cardiac involvement; these included 47 men (74.6%) and 16 women (25.4%). Of these 63 patients, most (74.6%) exhibited valvular lesions, especially aortic regurgitation. The primary characteristic manifestations of valves were cusp prolapse with aneurysmal changes, vegetation-like lesions and echo-free spaces within the annulus. Second (30.0%) were aortic lesions, including aortic dilation or aneurysm formation, aortic pseudoaneurysm and coronary sinus aneurysm. Other manifestations, such as cardiac thrombosis, coronary arterial pseudoaneurysm, pulmonary aneurysm and pericardial effusion, were rare. Cardiac involvement is not uncommon in Behçet's patients, especially in males, and it is characterized by valvular disease, especially aortic regurgitation. The diagnosis of Behçet's disease should be considered when evaluating patients with these characteristic echocardiographic manifestations. 相似文献
102.
Fei Yang Isaac Yaw Massey Jian Guo Shu Yang Yuepu Pu Weiming Zeng 《Journal of toxicology and environmental health. Part A》2018,81(7):184-193
Microcystins (MC) produced by species of cyanobacteria including Microcystis, Anabaena, and Aphanizomenon are a group of monocyclic hepatotoxins posing serious threat to public health. Microcystin-LR (MC-LR) is the most toxic and frequently encountered microcystin variant in the environment, and thus removal of this toxin using bacteria was shown to be a reliable, efficient, and cost-effective method that avoids utilization of chemicals that may produce potentially harmful by-products. The aim of this study was to determine whether a novel indigenous bacterial community designated YFMCD1 was effective in destroying MC. In addition, the influence of environmental factors such as temperature, MC concentration, and pH was examined on the effectiveness of YFMCD1 to degrade MC-LR. MC-degradation products were identified by high performance liquid chromatography coupled with an ultra-high resolution LTQ Orbitrap Velos Pro ETD mass spectrometry equipped with electrospray ionization interface (HPLC-ESI-MS). MC-LR underwent maximal degradation at rate of 0.5 µg/ml/hr with YFMCD1 containing Klebsiella sp. termed YFMCD1-1 or Stenotrophomonas sp. termed YFMCD1-2. Moreover, Adda (3-amino-9-methoxy-2, 6, 8-trimethyl-10-phenyldeca-4, 6-dienoic acid) is a constituent within the MC-LR molecule found to be responsible for biological activity expression and critical for MC-induced toxicity, which is also degraded by YFMCD1. The results showed that YFMCD1 effectively degraded MC-LR. The degradation rate was significantly affected by temperature, pH, and MC-LR concentrations. Data indicate that this bacterial community may prove beneficial in bioremediation of lakes containing MC. 相似文献
103.
目的研究冬连三七组分(Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids CONR)调控AGEs/p38MAPK信号转导通路改善糖尿病动脉粥样硬化(diabetic atherosclerosis,DA)兔氧化应激反应。方法设立空白组、模型组、辛伐他汀组、CONR高剂量组、CONR低剂量组、SB203580组;脉推注四氧嘧啶并且配合腹主动脉内膜球囊损伤术诱导雄性纯种新西兰大白兔的DA模型,实验组分别每日给予CONR450 mg/kg、CONR 150 mg/kg;辛伐他汀3 mg/kg灌胃10周,12 h重复腹腔注射SB203580 2 mg/kg 10周;正常组每日给予生理盐水20mL灌胃作为对照。结果实验各组对AGEs均有降低作用,对p-p38MAPK蛋白高表达均有抑制作用,与模型组比较差异有统计学意义。CONR高、低剂量组、辛伐他汀组对p-p38MAPK蛋白的抑制作用优于SB203580组(P<0.01),CONR高、CONR低剂量组、辛伐他汀组之间差异无统计学意义(P>0.05)。模型组大兔血清MDA高于空白组,有统计学差异(P<0.01)。给药后,CONR高剂量组、SB203580组及辛伐他汀组显著降低MDA(P<0.01)。模型组SOD活性显著降低(P<0.01),实验各组显著增强SOD活性(P<0.01)。结论冬连三七组分可能通过干预AGEs/p38MAPK信号转导通路改善DA兔的氧化应激反应。 相似文献
104.
Vincent Pong Koon-Ho Chan Boon-Hor Chong Wai-Man Lui Gilberto Ka-Kit Leung Hung-Fat Tse Jenny Kan-Suen Pu Chung-Wah Siu 《Cerebellum (London, England)》2012,11(4):939-945
Cerebellar hemorrhage is the least common type of intracranial hemorrhage (ICH) encountered in clinical practice, and clinical data concerning the long-term outcomes are limited. This study aimed to investigate the long-term outcomes following spontaneous cerebellar hemorrhage in a cohort of Chinese patients. This single-center observational study was carried out between 1996 and 2010 and included 72 consecutive Chinese patients with a first spontaneous cerebellar hemorrhage. Of 440 patients with primary ICH, 72 (16.4%) had primary cerebellar hemorrhage. The mean age was 67.5?±?12.3?years and patients were predominantly male (54%). The 30-day mortality was 16.7% with Glasgow coma scale ??8 as the only predictor. At 6?months, 56.7% of patients who survived the first 30?days had a persistently poor functional status with modified Rankin scale score >2. After a mean follow-up of 4.7?years, 3.3% of patients had recurrent ICH, a recurrence rate of 7.3 per 1,000 patient-years. Ischemic stroke occurred in 12% of patients, an incidence of 25.5 per 1,000 patient-years. This study provided data on the long-term outcome of post-cerebellar hemorrhage in Chinese patients. 相似文献
105.
Kui Zhang Bin Zhou Peng Zhang Zhu Zhang Peng Chen Yan Pu Yaping Song Lin Zhang 《Tumour biology》2014,35(5):4031-4040
Nicotinamide phosphoribosyltransferase (Nampt) was served as a useful biomarker for tumorigenesis and for the prediction of cancer survival. In the present study, we analyzed the SNPs of the NAMPT gene and their impact on the susceptibility and prognosis for patients with bladder cancer (BC). The rs61330082, rs2505568 and rs9034 were selected and genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method in 407 patients with bladder cancer and 316 ethnicity-matched healthy control subjects. The genotyping method was confirmed by the DNA sequencing analysis. Statistically significant increased bladder cancer risk was found to be associated with the C allele and CC genotype of rs61330082; nevertheless, decreased bladder cancer risk was revealed to be associated with A allele and AT genotype of rs2505568. Stratified analyses revealed the rs61330082 to be statistically associated with increased bladder cancer risk in smokers and increased invasiveness of bladder cancer. The AT heterozygote of rs2505568 may prevent the recurrence of bladder cancer. Kaplan-Meier curves revealed a statistically significant association of rs2505568 with recurrence-free survival for total bladder cancer patients and non-muscle-invasive bladder cancer patients, and a statistically significant association of rs9034 with recurrence-free survival for muscle-invasive bladder cancer patients. Multiple Cox regression analysis identified the rs2505568 as a possible independent prognostic factor for recurrence-free survival in total bladder cancer patients. Our results suggested an important role for NAMPT in the pathogenesis of bladder cancer and SNPs of NAMPT gene might be a novel genetic biomarker for the prognosis of bladder cancer. 相似文献
106.
Zhuohua Fu Na He Song Duan Qingwu Jiang Runhua Ye Yongcheng Pu Genming Zhao Z. Jennifer Huang Frank Y. Wong 《AIDS and behavior》2011,15(5):1017-1025
This cross-sectional study examined HIV prevalence, sexual behaviors, sexual networks, and drug use among 591 participants
from a rural community in Yunnan Province, China. Face-to-face interviews were conducted to collect information about sexual
behavior, drug use, and sexual networks. Blood samples were collected and tested for HIV. Of the participants, 52.6% were
male and 62.6% were Jingpo minority. The HIV prevalence was 5.5% overall and highest among the Jingpo minority (7.7%). Most
participants were sexually experienced and 32.5% had had multiple sex partners. About 18.8% had used drugs, with the highest
proportion among the Jingpo minority. HIV infection was independently correlated with drug use among males and with multiple
sexual partnerships among females. A total of 336 independent sexual network components (mostly small, linear, and acyclic)
were constructed. Eighty-percent were dyads involving two members and 20% involved three to 71 members. Coupled with the promotion
of condom use, gender- and network-specific efforts are needed for HIV prevention targeting ethnic minorities in Yunnan. 相似文献
107.
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109.
Hirotsugu Uemura Dingwei Ye Ravindran Kanesvaran Edmund Chiong Bannakij Lojanapiwat Yeong-Shiau Pu Sudhir Kumar Rawal Azad Hassan Abdul Razack Hao Zeng Byung Ha Chung Noor Ashani Md Yusoff Chikara Ohyama Choung Soo Kim Sunai Leewansangtong Yuh-Shyan Tsai Yanfang Liu Weiping Liu Maximiliano van Kooten Losio Marxengel Asinas-Tan 《BJU international》2020,125(4):541-552
110.
Jiaqian Xu MD Adrian L. Lata MD Li Zhou MD Bharathi Upadhya MD Min Pu MD PhD 《Echocardiography (Mount Kisco, N.Y.)》2020,37(10):1687-1690
The choice of anticoagulant agents for newly implanted bioprosthetic valve varies significantly, particularly in the presence of postoperative atrial fibrillation with increasing use of nonvitamin K oral anticoagulation (NOACs) in recent years. We reported a challenging case with a coexisting bioprosthetic aortic valve thrombosis and significant anticoagulant-related bleeding. Clinical management strategy and brief literature review were presented. 相似文献