Effects of Activated Complement on Lung Fluid Exchange in Conscious Goats:Role of Superoxide Anion

The effects of zymosan-activated plasma(ZAP)on lung fluid exchangeand on superoxide anion production by granulocytes were studied in 8 consciousgoats with chronic lung lymph fistula,It was found that after ZAP infusion, thecirculating granulocytes were activated and the release of superoxide anions wasmarkedly enhanced. There was an increase in lung lymph flow and proteinconcentration.It suggests that the superoxide anion released by the stimulatedgranulocytes can play a role in inducing lung injury by the activated complement.     

原发性醛固酮增多症的定位诊断与手术径路选择的初步研究——附10例报告

收治10例原发性醛固酮增多症。所有病例术前均经B超、CT扫描、血管造影及取肾上腺静脉血测醛固酮浓度4种定位方法检查。CT扫描和取肾上腺静脉血样分别获得75％和71.4％的肾上腺腺瘤诊断准确率。综合上述4种方法,7侧术前做出腺瘤定位诊断,其中5例获得术中和病理组织学证实,定位准确率为71.4％。并对手术入路的选择进行讨论,单侧腰切口仍然不能代替经腹切口。     

应用乳酸杆菌对非特异性阴道炎和滴虫性阴道炎的治疗观察

我们用乳酸杆菌制剂对30例非特异性阴道炎和29例滴虫性阴道炎进行了治疗及菌群分析。结果表明,这两种阴道炎病人的阴道乳酸杆菌的平均水平明显低于正常值,而肠杆菌、葡萄球菌和类杆菌却明显增多。因此,阴道炎可能是由于菌群失调引起的。乳酸杆菌是阴道正常优势菌,并对致病菌有拮抗作用,这对维持阴道微环境,保持健康状态是非常重要的。     

Percutaneous transluminal coronary angioplasty in a patient with paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired chronic hemolytic anemia associated with an unusual susceptibility to hemolytic crisis, infection, and venous thrombosis which would be aggravated by a number of factors including surgery. We report a case of PNH undergoing percutaneous transluminal coronary angioplasty and discuss the corresponding perioperative management.     

99Tcm and 111In leucocyte scintigraphy in inflammatory bowel disease.

A comparative study of 99Tcm-hexamethylpropyleneamine oxime (HMPAO) and 111In leucocyte scintigraphy was performed in inflammatory bowel disease. Two hundred and thirty-four patients were studied, 146 had 99Tcm-HMPAO, 82 had 111In and six had both. The sensitivity, specificity and accuracy of the 99Tcm leucocyte scan were 96, 97 and 97%, respectively, and 96, 97 and 97%, respectively, for the 111In leucocyte scan. 99Tcm-HMPAO leucocytes demonstrated similar diagnostic accuracy to 111In-labelled leucocytes with improved image quality and reduced radiation dose.     

急性重复性缺氧小鼠脑组织中儿茶酚胺类神经递质含量变化的研究

用高效液相-电化学检测器测定急性重复性缺氧小鼠脑组织中DOPA、DA、NE和Ep等儿茶酚胺类物质的含量。结果发现:与空白对照组(A组)比较,缺氧1次的实验对照组(B组)及急性重复缺氧4次实验组(C组),随缺氧次数增加,小鼠脑组织中的DA含量显着上升(P<0.01),NE、DOPA含量明显降低(P<0.05或<0.01);A组与急性重复4次缺氧后饲养2d的实验对照组(D组)小鼠脑组织中儿茶酚胺类含量接近,没有统计学意义(P=23.77).结果提示脑组织中儿茶酚胺类物质可能参与急性重复缺氧小鼠的耐缺氧能力的形成,而且是一个可逆的快反应。     

Effect of Salvia miltiorrhiza on the left ventricular diastolic function in coronary artery stenosis

In 24 open-chest mongrel dogs, coronary artery critical stenosis were produced by a micrometer constriction on left circumflex coronary artery. It was reduction about 87% in lumen area. CBF, -Vce, -dp/dt max were decreased, T was increased (P less than 0.01). 15 minutes after stenosis, the Salvia miltiorrhiza injection was injected into left atrium. CBF, -dp/dt max, -Vce were increased and T was decreased after the injection of Salvia miltiorrhiza. Moreover, the change of CBF was the earliest. The results proved that the Salvia miltiorrhiza could improve the left ventricular diastolic function in coronary artery stenosis.     

乙型肝炎甲胎蛋白检测与重型肝炎预后指数评估的意义

给慢性活动肝炎患者输注人胎肝细胞悬液引起血清甲胎蛋白增高反应的初浓度为２０２±３８．３μｇ／Ｌ，其半衰期为１．７天；分布池为６．９一１０．２升。重型肝炎生存组血清甲胎蛋白显著高于死亡组，生存组甲胎蛋白与血清总胆红素呈非常显著相关，而死亡组两者无相关性。重型肝炎患者输注胎肝悬液后其血清甲胎蛋白进一步升高者，预后较好。取重型肝炎预后指数０．１为重型肝炎生死的截断点，判断预后的灵敏度、特异度、准确度和阳性预告值分别为７９．５％、８９．６％、８４．８％和８７．５％。重型肝炎预后指数的计算可作为判断预后与新疗法疗效的指标。     

大黄对实验性糖尿病大鼠肾脏肥大及高滤过作用的影响

肾脏肥大和高滤过是糖尿病肾病出现最早的病理生理特征。本研究利用中药大黄抑制糖尿病的肾脏肥大,试图达到控制其高滤过现象。实验结果表明,大黄能明显地抑制糖尿病肾脏肥大及其组织中蛋白质、DNA含量的增加;大黄治疗组的菊粉清除率明显低于非治疗组;此外,大黄还能使糖尿病血清甘油三酯、胆固醇水平降低。结论:大黄可以通过影响糖尿病肾病肾脏肥大,降低高滤过和纠正血脂代谢紊乱,治疗实验性糖尿病肾病动物模型。     

念珠状链杆菌在小鼠群中的自然感染和发病特征的观察

本文在国内首次报告了念珠状链杆菌在清洁级Ｃ５７ＢＬ／６Ｊ小鼠群中的自然感染，并从临床、病理解剖、病原学及流行病学方面进行了较为详细的观察，在受检的１４例发病动物中，颈部淋巴结肿大、化脓占７１．４％，皮下、肺门淋巴结脓肿分别占５０．０％和２１．４％，多发性关节炎（包括趾、跗关节）占２１．４％，子宫积脓占７．１％，从所有病灶及部分动物的血液、脾、肝、肺、肾均分离到了单一的细菌。该菌在小鼠成功地进行了急性感染实验，受感染动物出现了典型的念珠状链杆菌病的临床及病理特征，即败血症、关节炎、淤血、水肿、紫绀、结膜炎等。所分离的致病菌在病原学上也完全符合念珠状链杆菌的病原学特征。在饲养环境上与发病鼠群有密切关系的其它４个品系小鼠群，即６１５、ＢＡＬＢ／ｃ、ＣＢＡ、ＫＭ，均未波感染，证明在对该菌的易感性方面存在品系差异。