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61.
Monica Uddin Ph.D. Levent Sipahi B.A. Jia Li Ph.D. Karestan C. Koenen Ph.D. 《Depression and anxiety》2013,30(12):1151-1160
There are well‐established sex differences in the prevalence of certain mental disorders. Work in animal models has provided us with an emerging understanding of the role that epigenetic factors play in establishing sex differences in the brain during development. Similarly, work in animal models, and a more limited but growing literature based on human studies, has demonstrated that DNA methylation (DNAm) changes occur in response to environmental stress, with some of these occurring in a sex‐specific manner. In this review, we explore whether DNAm plays a role in contributing to the observed sex differences in prevalence of mental disorders in which stress contributes significantly to their etiologies, specifically posttraumatic stress disorder (PTSD) and depression. We propose that investigating sex differences in DNAm among genes known to influence brain development may help to shed light on the sexually dimorphic risk for, or resilience to, developing PTSD and depression. 相似文献
62.
Selcuk Aslan Zeynep Gulcat F Selda Albayrak Isil Maral Sinan Yetkin Levent Sutcigil 《International journal of psychiatry in clinical practice》2013,17(1):52-58
Objective. Characteristics of insomnia symptoms in Turkey are not well established. The goal of this study was to determine the prevalence of insomnia and related symptoms in an urban district of Turkey. Method. The study was carried out in Ankara, in an urban district with a population of 2665. Out of the 1332 people in the sample, 1034 in the 15–65 age range were included in the study. Interviews were conducted according to the “Sleep Disorders Assessment Questionnaire” developed by the researchers. The Insomnia Severity Index (ISI) was also given to the subjects with a sleep problem to measure the subjective quality and quantity of insomnia symptoms. Results and conclusion. A total of 29.4% of all participants reported a sleep problem, out of which 23.7% defined one or more of the insomnia symptoms which included difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), early morning awakening (EMA), non-restorative sleep (NRS) and sleep deprivation (SD). Insomnia risk was found to be significantly increased with age, female sex, smoking and chronic medical illness. A total of 75.9% of participants who reported insomnia symptoms did not seek medical help for their complaint. According to the ISI, among the subjects with insomnia symptoms, 79 (32.2%) had subthreshold insomnia, 43 (17.6%) had clinical insomnia, 12 (4.9%) had severe clinical insomnia, while 88 (35.9%) did not score in the range indicating insomnia. The findings are discussed in the light of previous research and in relation to sociocultural factors emphasizing the need for public education on sleep disorders as medical conditions. 相似文献
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Filik L 《Journal of general internal medicine》2012,27(7):763; author reply 764-764
65.
Aytekin E Caglar NS Ozgonenel L Tutun S Demiryontar DY Demir SE 《Clinical rheumatology》2012,31(1):91-97
The home-based exercise therapy recommended to the patients with ankylosing spondylitis (AS) is a simply applicable and cheap
method. The aim of this study was to investigate the effects of home-based exercise therapy on pain, mobility, function, disease
activity, quality of life, and respiratory functions in patients with AS. Eighty patients diagnosed with AS according to the
modified New York criteria were included in the study. Home-based exercise program including range of motion, stretching,
strengthening, posture, and respiratory exercises was practically demonstrated by a physiotherapist. A training and exercise
manual booklet was given to all patients. Patients following home-based exercise program five times a week at least 30 min
per session (exercise group) for 3 months were compared with those exercising less than five times a week (control group).
Visual analog scale pain (VASp) values at baseline were significantly higher in the exercise group. The exercise group showed
improvements in VASp, tragus–wall distance, morning stiffness, finger–floor distance, modified Schober's test, chest expansion,
the Bath Ankylosing Spondylitis Disease Activity Index, the Bath Ankylosing Spondylitis Functional Index, Ankylosing Spondylitis
Quality of Life Questionnaire (ASQoL), forced expiratory volume in first second, and forced vital capacity at third month.
There was significant difference in ASQoL scores between the two groups in favor of the exercise group at third month. Regular
home-based exercise therapy should be a part of main therapy in patients with AS. Physicians should recommend that patients
with AS do exercise at least five times a week at least 30 min per session. 相似文献
66.
Aytemir K Oto A Ozkutlu S Kaya EB Canpolat U Yorgun H Sahiner L Kabakçi G 《Journal of interventional cardiology》2012,25(4):375-381
Background: Percutaneous closure of secundum type atrial septal defect (ASD) and patent foramen ovale (PFO) has gained widespread use in recent years. Herein, we evaluated the safety and efficacy of the Occlutech® Figulla devices for PFO and ASD closure in a reference tertiary center. Methods: All 143 patients (46.9% male, mean age 39.3 ± 12.2 years) who underwent transcatheter PFO (n = 85) and ASD (n = 58) closure with Occlutech® Figulla devices between February 2009 and October 2011 were included in this study. An echocardiographic follow‐up examination was performed at the 1st, 6th, and 12th month visits. Results: The devices were successfully implanted in all 143 patients (100%). In‐hospital periprocedural complications were device embolization (0.7%; 1 ASD patient), atrial fibrillation (1.4%; 1 ASD and 1 PFO patients), supraventricular tachycardia (0.7%; 1 PFO patient), and vascular access hematoma (0.7%; 1 ASD patient). Among ASD patients, 2 patients had trivial (jet width <1 mm in diameter) and 1 patient had small (1–2 mm) residual shunts before hospital discharge, which disappeared after the 6‐month visit. During the mean 15.4 ± 9.6 months follow‐up, all patients were asymptomatic and no ischemic stroke, cardiac perforation, device erosion, embolization, thrombus formation, or malposition of the device was observed. Conclusions: Percutaneous PFO and secundum type ASD closure with the novel Occlutech® Figulla Occluder devices without left atrial central pin and with significantly reduced meshwork was safe, feasible, and effective. (J Interven Cardiol 2012;25:375–381) 相似文献
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Levent Sinan Bir MD PhD Fatma Özdemir Eşmeli MD Utku Cenikli MD ×ağdaş Erdoğan MD Eylem Değirmenci MD 《The journal of spinal cord medicine》2013,36(3):294-296
AbstractCase report: A 25-year-old man with BehÇet's disease was admitted because of weakness of the lower limbs and difficulty in urination. He had received a rabies vaccination 2 months previous because he had been bitten by a dog.Findings: Clinical and laboratory findings supported acute transverse myelitis. A hyperintense lesion and expansion at the level of conus medullaris was detected on spinal magnetic resonance imaging.Conclusion: Although neurologic involvement is one of the main causes of mortality and morbidity in BehÇet's disease, the factors that aggravate the involvement of the nervous system are still unclear. Vaccination may have been the factor that had activated autoimmune mechanisms in this case. To our knowledge, involvement of the conus medullaris in BehÇet's disease after rabies vaccination has not been reported. 相似文献