全文获取类型
收费全文 | 6669篇 |
免费 | 603篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 171篇 |
妇产科学 | 294篇 |
基础医学 | 885篇 |
口腔科学 | 50篇 |
临床医学 | 1019篇 |
内科学 | 1027篇 |
皮肤病学 | 168篇 |
神经病学 | 505篇 |
特种医学 | 136篇 |
外国民族医学 | 1篇 |
外科学 | 836篇 |
综合类 | 151篇 |
一般理论 | 12篇 |
预防医学 | 818篇 |
眼科学 | 55篇 |
药学 | 592篇 |
中国医学 | 7篇 |
肿瘤学 | 494篇 |
出版年
2023年 | 19篇 |
2022年 | 42篇 |
2021年 | 109篇 |
2020年 | 56篇 |
2019年 | 115篇 |
2018年 | 136篇 |
2017年 | 106篇 |
2016年 | 138篇 |
2015年 | 143篇 |
2014年 | 209篇 |
2013年 | 326篇 |
2012年 | 473篇 |
2011年 | 458篇 |
2010年 | 280篇 |
2009年 | 244篇 |
2008年 | 442篇 |
2007年 | 434篇 |
2006年 | 405篇 |
2005年 | 393篇 |
2004年 | 390篇 |
2003年 | 336篇 |
2002年 | 306篇 |
2001年 | 145篇 |
2000年 | 97篇 |
1999年 | 108篇 |
1998年 | 66篇 |
1997年 | 54篇 |
1996年 | 55篇 |
1995年 | 62篇 |
1994年 | 40篇 |
1993年 | 51篇 |
1992年 | 101篇 |
1991年 | 84篇 |
1990年 | 62篇 |
1989年 | 80篇 |
1988年 | 57篇 |
1987年 | 51篇 |
1986年 | 42篇 |
1985年 | 61篇 |
1984年 | 64篇 |
1983年 | 46篇 |
1982年 | 35篇 |
1981年 | 30篇 |
1980年 | 26篇 |
1979年 | 35篇 |
1978年 | 24篇 |
1977年 | 23篇 |
1976年 | 19篇 |
1974年 | 26篇 |
1973年 | 23篇 |
排序方式: 共有7283条查询结果,搜索用时 390 毫秒
91.
Pui Fung Li Mark A. McEvoy Sharmaine McKiernan Peter W. Schofield Lesley K. MacDonald-Wicks Amanda J. Patterson 《Nutrients》2021,13(3)
There is a lack of evidence to determine if diet quality is associated with cognitive performance in older adults. Therefore, the aim of this study was to examine whether diet quality is associated with cognitive performance among older adults. A cross-sectional, secondary analysis of baseline data from the Hunter Community Study (HCS), comparing diet quality, measured using the Australian Recommended Food Score (ARFS), along with validated cognitive performance instruments the Audio Recorded Cognitive Screen (ARCS) and the Mini-Mental State Examination (MMSE) were undertaken in adults aged 55–85 years, living in Newcastle, NSW, Australia. Adjusted linear regression analyses showed that, compared with the lowest ARFS quintile, those in the highest quintile had an ARCS score 5.883 units greater (p < 0.001; R2 = 0.0098). Furthermore, when quintiles of ARFS score were tested against each ARCS sub-scale score, statistically significant associations were observed with the greatest effect for the Memory (β = 4.055; p = 0.001; R2 = 0.0065) and Attention (β = 4.136; p = 0.002; R2 = 0.0047) domains. No statistically significant associations were observed between quintiles of ARFS and MMSE score in the adjusted linear regression analyses. In conclusion, a positive association was observed between diet quality and cognitive performance within this sample of older Australian adults. Further investigation of the above association over time, when follow-up data becomes available, in longitudinal analysis is recommended. 相似文献
92.
93.
94.
Alessia Di Carlo Michael Leveridge Thomas B. McGregor 《Canadian Urological Association journal》2021,15(3):E139
IntroductionCrowdfunding is becoming an increasingly used resource for patients to cover costs related to medical care. These costs can be related directly to treatments or indirectly to loss of income or travel-related costs. Little is known as to the extent of which crowdfunding is used for urological disease here in Canada. This study offers a first look at the prevalence of crowdfunding for urological disease and the factors surrounding its use.MethodsIn January 2020, we queried the GoFundMe internal search engine for fundraising campaigns regarding urological ailments. Results were categorized according to the major organs of urological disease.ResultsCrowdfunding campaigns are very prevalent within several areas of urology. Prostate cancer and chronic kidney disease represent the most frequent reason for campaigns. Fundraising goals and actual funds raised for malignant disease were significantly more than for benign disease. Interestingly, there was a significant portion of crowdfunding campaigns to cover costs for non-conventional treatments and transplant tourism.ConclusionCrowdfunding use to help cover direct and indirect costs of medical care is becoming increasingly apparent through several facets of medicine. This study shows that this statement holds true when looking at patients with urological disease in Canada. As urologists, we need to be aware of this trend, as it highlights the often-unforeseen financial burdens experienced by our patients. 相似文献
95.
Carmen H Logie Moses Okumu Daniel Kibuuka Musoke Robert Hakiza Simon Mwima Peter Kyambadde Heather Abela Lesley Gittings Joshua Musinguzi Lawrence Mbuagbaw Stefan Baral 《Journal of the International AIDS Society》2021,24(3)
IntroductionHIV‐related risks may be exacerbated in humanitarian contexts. Uganda hosts 1.3 million refugees, of which 60% are aged under 18. There are knowledge gaps regarding HIV testing facilitators and barriers, including HIV and intersecting stigmas, among urban refugee youth. In response, we explored experiences and perspectives towards HIV testing strategies, including HIV self‐testing, with urban refugee youth in Kampala, Uganda.MethodsWe implemented a qualitative study with refugee cisgender youth aged 16 to 24 living in Kampala''s informal settlements from February‐April 2019. We conducted five focus groups with refugee youth, including two with adolescent boys and young men, two with adolescent girls and young women and one with female sex workers. We also conducted five key informant (KI) interviews with government, non‐government and community refugee agencies and HIV service providers. We conducted thematic analyses to understand HIV testing experiences, perspectives and recommendations.ResultsParticipants (n = 49) included young men (n = 17) and young women (n = 27) originally from the Democratic Republic of Congo [DRC] (n = 29), Rwanda (n = 11), Burundi (n = 3) and Sudan (n = 1), in addition to five KI (gender: n = 3 women, n = 2 men; country of origin: n = 2 Rwanda, n = 2 Uganda, n = 1 DRC). Participant narratives revealed stigma drivers included fear of HIV infection; misinformation that HIV is a “Ugandan disease”; and blame and shame for sexual activity. Stigma facilitators included legal precarity regarding sex work, same‐sex practices and immigration status, alongside healthcare mistreatment and confidentiality concerns. Stigma experiences were attributed to the social devaluation of intersecting identities (sex work, youth, refugees, sexual minorities, people living with HIV, women). Participants expressed high interest in HIV self‐testing. They recommended HIV self‐testing implementation strategies to be peer supported and expressed concerns regarding sexual‐ and gender‐based violence with partner testing.ConclusionsIntersecting stigma rooted in fear, misinformation, blame and shame, legal precarity and healthcare mistreatment constrain current HIV testing strategies with urban refugee youth. Findings align with the Health Stigma and Discrimination Framework that conceptualizes stigma drivers and facilitators that devalue intersecting health conditions and social identities. Findings can inform multi‐level strategies to foster enabling HIV testing environments with urban refugee youth, including tackling intersecting stigma and leveraging refugee youth peer support. 相似文献
96.
97.
Mozafarinia Maryam Rajabiyazdi Fateme Brouillette Marie-Josee Fellows Lesley K. Mayo Nancy E. 《Quality of life research》2021,30(11):3199-3211
Quality of Life Research - (1) To develop a personalized health outcome profile as a feedback tool to improve self-management in people living with chronic conditions such as HIV and (2) to... 相似文献
98.
99.
Deborah L. Scarcella Lesley J. Bryan-Lluka 《Naunyn-Schmiedeberg's archives of pharmacology》1995,351(5):491-499
The aim of this study was to investigate the deamination of dopamine in the intact pulmonary circulation of isolated lungs of the rat. The first part of the study showed that dopamine is not converted to noradrenaline by dopamine--hydroxylase (DBH) when dopamine is perfused through isolated lung preparations with monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) inhibited. Hence, it was not necessary to inhibit DBH in subsequent experiments.The metabolite profile for deamination of dopamine in the lungs was examined by determining whether MAO and semicarbazide-sensitive amine oxidases (SSAO) contribute to the deamination of dopamine (and noradrenaline), and by determining the activity of MAO (kMAO) for the metabolism of dopamine. Lungs were perfused with I nmol/l 3H-dopamine or 3H-noradrenaline with COMT inhibited and, in experiments to determine the contribution of SSAO to deamination, with MAO inhibited. Inhibition of MAO reduced the deamination of dopamine and noradrenaline by 99.8% and 98.6%, respectively, indicating that MAO, and not SSAO, was responsible for deamination of the catecholamines in the lungs. The kMAO value for deamination of dopamine was 3.89 min–1. Further experiments were carried out to determine the contributions of MAO-A and MAO-B to the deamination of dopamine in lungs perfused with 1 nmol/l 3H-dopamine and 100 nmol/1 lazabemide or 300 nmol/I Ro41-1049, respectively. The values of kMAO-A and kMAO-B were 3.05 min–1 and 0.626 min–1, respectively.It was concluded that, in rat lungs, MAO-A contributed 78–84% and MAO-B 16–22% to the total deamination of dopamine and SSAO had no significant role in its pulmonary metabolism. These relative contributions of MAO-A and MAO-B to the deamination of dopamine are very similar to those that have been determined previously for noradrenaline, but the rate constant for deamination of dopamine is 26-fold greater than that for noradrenaline in rat lungs.Abbreviations COMT
Catechol-O-methyltransferase
- DBH
Dopamine-\-hydroxylase
- DOPEG
3,4-dihydroxyphenylglycol
- DOMA
3,4-dihydroxyman delic acid
- DOPAC
3,4-dihydroxyphenylacetic acid
- DOPET
3,4-dihydroxphenylethanol
- ECS
Extracellular space
- Km
Michaelis or half-saturation constant
- kCOMT
Rate constant for O-methylation by COMT
- kdeam
Rate constant for total deamination
- kMAO
Rate constant for deamination by MAO
- MAO
Monoamine oxidase
- MB-COMT
Membrane-bound COMT
- SSAO
Semicarbazidesensitive amine oxidases
- S-COMT
Soluble COMT
- T/M
Tissue to medium concentration ratio of dopamine or noradrenaline
- Vmax
Maximal rate
- Vst - st
Steady-state rate of metabolite formation 相似文献
100.
Comparison of short vs. Long half-life single-dose prophylactic antibiotics for cesarean section
下载免费PDF全文
![点击此处可从《Infectious diseases in obstetrics and gynecology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Objective: Numerous studies demonstrate the efficacy of antibiotic prophylaxis for reducing postcesarean section infectious morbidity. The duration of therapy, however, remains controversial. Cost containment measures and the ease of single dosing have led to the introduction of "extended" half-life agents for cesarean-section chemoprophylaxis. We tested the hypothesis that there was no difference in efficacy between a single dose of a short half-life agent (cefoxitin) and a longer half-life agent (cefotetan).Methods: A prospective, double-blind trial of 375 non-elective cesarean-section cases was carried out. Study antibiotics (2 g) were administered intravenously (IV) at cord clamping only.Results: Demographic and clinical variables between the 2 study groups were similar. No significant differences were noted in major or minor morbidity or in infectious morbidities for patients receiving the 2 prophylactic regimens. The occurrence of postoperative endometritis was likewise similar for the subjects receiving cefoxitin (10%) and cefotetan (15%). When cases whose surgery lasted >60 min were evaluated separately, no differences in outcomes between the 2 groups were identifiedConclusions: These findings confirm our hypothesis that the half-life difference between these 2 agents does not impact on single-dose Prophylactic efficacy in cesarean section. 相似文献