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81.
THE EFFECT OF CULTURAL FACTORS ON DAILY COPING AND INVOLUNTARY RESPONSES TO STRESS AMONG LOW‐INCOME LATINO ADOLESCENTS 下载免费PDF全文
Catherine DeCarlo Santiago Stephanie A. Torres Stephanie K. Brewer Anne K. Fuller Jaclyn M. Lennon 《Journal of community psychology》2016,44(7):872-887
This study used daily diary methodology to examine associations between cultural factors and daily coping and responses to stress among predominantly low‐income Latino adolescents. A total of 58 middle school students (53% male, mean age = 13.31, 95% Latino) completed baseline measures assessing demographic characteristics, familism, ethnic identity, and family ethnic socialization. They subsequently completed 7 consecutive daily diaries assessing daily stress, coping, and involuntary stress responses. Results yielded main effects of stress, gender, familism, and ethnic identity on adolescents’ coping and involuntary stress responses. In addition, interactions between stress and familism, ethnic identity, and family ethnic socialization emerged. Results suggest that familism may promote adaptive responses to stress, while adolescents who report more family ethnic socialization may rely more on maladaptive responses at high levels of stress. Findings related to ethnic identity were mixed and varied depending on levels of ethnic identity exploration versus commitment. 相似文献
82.
83.
ACh receptor protein drives primary and memory autoantibody responses in chimeric human-SCID mice 总被引:1,自引:0,他引:1
The native antigen that drives the T-helper cells regulating production of muscle acetylcholine receptor (AChR) autoantibodies is unknown. Human T cell lines activated by autoantigens in vitro are of unproven relevance to B cell help. Here we report the functional interaction and unprecedented longevity of AChR-specific human T and B lymphocytes residing in SCID mice. Lymphoid cells from myasthenia gravis (MG) patients and healthy subjects were injected ip. Recombinant human AChR-alpha1-subunit-1-210 was injected after day 75. Human AChR-specific Ig was produced rapidly in MG-SCID mice challenged once. Only 1 of 32 control hu-SCID mice produced AChR-specific Ig. This required multiple immunizations, was initially cross-reactive with Torpedo AChR, and had a slow course. Thus, memory T and B lymphocytes specific for human AChR-alpha1-subunit are readily demonstrable in MG patients, interact to produce autoantibody of the same restricted specificity found in the donor's serum, and are long-lived without exogenous autoantigen challenge. In healthy subjects, AChR-specific lymphocytes are infrequent and exhibit naive response characteristics, including apparent affinity maturation of Ig specificity. 相似文献
84.
85.
Survey of CAG/CTG repeats in human cDNAs representing new genes: candidates for inherited neurological disorders 总被引:3,自引:2,他引:3
Neri C; Albanese V; Lebre AS; Holbert S; Saada C; Bougueleret L; Meier-Ewert S; Le Gall I; Millasseau P; Bui H; Giudicelli C; Massart C; Guillou S; Gervy P; Poullier E; Rigault P; Weissenbach J; Lennon G; Chumakov I; Dausset J; Lehrach H; Cohen D; Cann HM 《Human molecular genetics》1996,5(7):1001-1009
86.
M Martinez L R Goldin Q Cao J Zhang A R Sanders D J Nancarrow J M Taylor D F Levinson A Kirby R R Crowe N C Andreasen D W Black J M Silverman D P Lennon D A Nertney D M Brown B J Mowry E S Gershon P V Gejman 《American journal of medical genetics》1999,88(4):337-343
Evidence for suggestive linkage to schizophrenia with chromosome 6q markers was previously reported from a two-stage approach. Using nonparametric affected sib pairs (ASP) methods, nominal p-values of 0.00018 and 0.00095 were obtained in the screening (81 ASPs; 63 independent) and the replication (109 ASPs; 87 independent) data sets, respectively. Here, we report a follow-up study of this 50cM 6q region using 12 microsatellite markers to test for linkage to schizophrenia. We increased the replication sample size by adding an independent sample of 43 multiplex pedigrees (66 ASPs; 54 independent). Pairwise and multipoint nonparametric linkage analyses conducted in this third data set showed evidence consistent with excess sharing in this 6q region, though the statistical level is weaker (p=0.013). When combining both replication data sets (total of 141 independent ASPs), an overall nominal p-value=0.000014 (LOD=3. 82) was obtained. The sibling recurrence risk (lambdas) attributed to this putative 6q susceptibility locus is estimated to be 1.92. The linkage region could not be narrowed down since LOD score values greater than three were observed within a 13cM region. The length of this region was only slightly reduced (12cM) when using the total sample of independent ASPs (204) obtained from all three data sets. This suggests that very large sample sizes may be needed to narrow down this region by ASP linkage methods. Study of the etiological candidate genes in this region is ongoing. 相似文献
87.
Molecular profiling of clinical tissue specimens: feasibility and applications 总被引:7,自引:0,他引:7 下载免费PDF全文
Emmert-Buck MR Strausberg RL Krizman DB Bonaldo MF Bonner RF Bostwick DG Brown MR Buetow KH Chuaqui RF Cole KA Duray PH Englert CR Gillespie JW Greenhut S Grouse L Hillier LW Katz KS Klausner RD Kuznetzov V Lash AE Lennon G Linehan WM Liotta LA Marra MA Munson PJ Ornstein DK Prabhu VV Prange C Schuler GD Soares MB Tolstoshev CM Vocke CD Waterston RH 《The American journal of pathology》2000,156(4):1109-1115
88.
Carel Bron Arthur de Gast Jan Dommerholt Boudewijn Stegenga Michel Wensing Rob AB Oostendorp 《BMC medicine》2011,9(1):8
Background
Shoulder pain is a common musculoskeletal problem that is often chronic or recurrent. Myofascial trigger points (MTrPs) cause shoulder pain and are prevalent in patients with shoulder pain. However, few studies have focused on MTrP therapy. The aim of this study was to assess the effectiveness of multimodal treatment of MTrPs in patients with chronic shoulder pain. 相似文献89.
BACKGROUND: A national prospective study of cardiovascular disease (CVD) was set up in 1978 to explain the reasons for the marked geographical variation in CVD rates in Great Britain. A total of 7735 males, aged 40-59 years (born between 1919 and 1939) randomly selected from one general practice age-sex register in each of 24 towns, responded to a screening invitation from their general practitioner (GP) and were examined in 1978-1980. We describe the methods used and the contact maintained after following a cohort for 20 years. METHODS: The established system of patient registration with a GP was used for tracing and maintaining contact with a low-mobility cohort through local area health authority networks and the National Health Service Central Register. RESULTS: By 31 December 1997, there were 1856 recorded deaths (14 known to have occurred abroad), 66 emigrations/ living overseas/lost from follow-up. In addition, 1500 study subjects had registered with new GPs who, every 2 years, provided information on both fatal and non-fatal cardiovascular events to complement information supplied by the original practices. Information was obtained on all cardiovascular events and deaths for 99.5 per cent of the surviving sample. Questionnaires mailed to surviving subjects 5 years after recruitment (1983-1985) and again in November 1992 and 1996 were returned by 98, 90 and 88 per cent, respectively, providing information on lifestyle changes, new cardiovascular symptoms and new diagnoses. CONCLUSION: Using the NHSCR framework for primary care registration procedures, maximum follow-up has been maintained. Brief and structured enquiry forms have gained and maintained co-operation from subjects and their GPs with considerable success. Mortality reporting from dual sources identified 5 per cent more cases. 相似文献
90.
Speer MC Graham FL Bonner E Collier K Stajich JM Gaskell PC Pericak-Vance MA Vance JM 《Neurogenetics》2002,4(2):83-85
As part of an on-going genomic screen of unlinked Charcot-Marie-Tooth disease type 2 (CMT2) families, we identified 11 regions
in the genome with lod scores ≥1.0. One of these regions was near the recently identified CMTDI1 locus on 19q. We show evidence of linkage of DUK 1118 to this region and our data reduce the minimum candidate interval for
CMTDI1 to the 9-cM interval spanned by D19S586 and D19S432.We also demonstrate that five additional CMT2 families are unlinked to 19q markers, providing further evidence of CMT2 heterogeneity.
Electronic Publication 相似文献