Therapeutische Aspekte bei traumatischen Rückenmarksschädigungen

Ohne Zusammenfassung     

Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin)

Platelet adhesion to fibrillar collagens (types I, II, III, and V) and nonfibrillar collagens (types IV, VI, VII, and VIII) was investigated in the presence of physiologic concentrations of divalent cations under conditions of stasis and flow. Under static conditions, platelet adhesion was observed to collagen types I through VII but not to type VIII. Under flow conditions, platelet adhesion to collagen types I, II, III, and IV was almost independent of shear rates above 300/s. Collagen type V was nonadhesive. Platelet adhesion to collagen type VI was shear rate-dependent and optimal at a rate of 300/s. Collagen types VII and VIII showed minor reactivity and supported platelet adhesion only between shear rates 100 to 1,000/s. Monoclonal antibody (MoAb) 176D7, directed against platelet membrane glycoprotein Ia (GPIa; very late antigen [VLA]-alpha 2 subunit), completely inhibited platelet adhesion to all collagens tested, under conditions of both stasis and flow. Platelet adhesion to collagen type III at shear rate 1,600/s was only inhibited for 85%. The concentration of antibody required for complete inhibition of platelet adhesion was dependent on the shear rate and the reactivity of the collagen. An MoAb directed against GPIIa (VLA-beta subunit) partially inhibited platelet adhesion to collagen. These results show that GPIa-IIa is a major and universal platelet receptor for eight unique types of collagen.     

Klinik,Therapie und Prognose des Kleinhirnmedulloblastoms

Zusammenfassung An Hand des eigenen Krankengutes wird, unterstützt durch Literaturangaben, ein Überblick über die Problematik der Medulloblastome des Kleinhirns gegeben. Es erfolgt unter Zugrundelegung des neurologischen und psychischen Befundes eine Stadieneinteilung, die für die Operations-prognose von Bedeutung ist. Die möglichst frühzeitige Erkennung der Erkrankung für die Verbesserung der Frühprognose wird besonders herausgestellt. Die schlechte Spätprognose konnte bisher trotz kombinierter operativ-radiologischer Therapie nicht wesentlich beeinflußt werden. Dauerheilungen gibt es praktisch nicht. Die Methode der Wahl ist nach ausgiebiger operativer Entlastung, falls notwendig unter Drainage des Hydrocephalus, eine Herdbestrahlung mit 3000–6000 R, unterstützt durch eine spinale Liquorraumbestrahlung von 2000–3000 R und evtl. die cerebrale Liquorraumbestrahlung.

---

Symptomatology, therapy and prognosis of cerebellar medulloblastoma

Summary The problems of cerebellar medulloblastomas are demonstrated again on the survey of 53 cases of the own collective and by literature. On the base of neurological and psychic findings it is made a classification of tumors with reference to the results of operation. Early recognition of the tumor is very important to the improvement of primary prognosis. Hitherto the bad prognosis in late sequella could not absolutely influenced by combined therapy. Cure of tumor seems to be impossible. Today's therapy is operation as radical as possible if necessary drainage of hydrocephalus by Pudenz — Heyer methode and a roentgen radiation focal with 3000–6000 r, the spinal fluid spaces with 2000–3000 r and eventually the cerebral ventricles.

     

Extracranial tumor vascularity: determination by dynamic CT scanning. Part II: The unit approach

Twenty-eight patients had combined conventional drip infusion CT scans. The information about the anatomic location of the lesion, its configuration, its cross-sectional appearance, its vascularity (as determined by dynamic signature curves), and its clinical presentation were considered as a single overall unit. This diagnostic approach allowed a diagnosis to be made on virtually all of these enhancing lesions without resorting to either a digital venous imaging study or angiographic procedure. In 17 of these cases, such an invasive second procedure was performed either to confirm the CT impression as part of this study or as part of a therapeutic embolization procedure.     

玻片法单人份免疫分型试剂盒在白血病诊断中的应用

0引言白血病免疫分型是指用已知的单克隆抗体(单抗)鉴定细胞表面或胞质内的分化抗原的方法.该方法的临床应用有利于白血病的鉴别及诊断.我们采用单人份免疫分型试剂盒对128例白血病患者进行了免疫分型.     

Direct medical costs of adverse events in Dutch hospitals

Background  

Up to now, costs attributable to adverse events (AEs) and preventable AEs in the Netherlands were unknown. We assessed the total direct medical costs associated with AEs and preventable AEs in Dutch hospitals to gain insight in opportunities for cost savings.