全文获取类型
收费全文 | 11030篇 |
免费 | 818篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 332篇 |
妇产科学 | 315篇 |
基础医学 | 1857篇 |
口腔科学 | 139篇 |
临床医学 | 1110篇 |
内科学 | 2385篇 |
皮肤病学 | 175篇 |
神经病学 | 823篇 |
特种医学 | 322篇 |
外国民族医学 | 1篇 |
外科学 | 1567篇 |
综合类 | 85篇 |
一般理论 | 23篇 |
预防医学 | 806篇 |
眼科学 | 187篇 |
药学 | 683篇 |
中国医学 | 13篇 |
肿瘤学 | 1000篇 |
出版年
2023年 | 56篇 |
2022年 | 99篇 |
2021年 | 229篇 |
2020年 | 147篇 |
2019年 | 241篇 |
2018年 | 265篇 |
2017年 | 156篇 |
2016年 | 193篇 |
2015年 | 252篇 |
2014年 | 330篇 |
2013年 | 503篇 |
2012年 | 779篇 |
2011年 | 844篇 |
2010年 | 483篇 |
2009年 | 383篇 |
2008年 | 754篇 |
2007年 | 801篇 |
2006年 | 773篇 |
2005年 | 748篇 |
2004年 | 710篇 |
2003年 | 659篇 |
2002年 | 664篇 |
2001年 | 88篇 |
2000年 | 76篇 |
1999年 | 103篇 |
1998年 | 164篇 |
1997年 | 100篇 |
1996年 | 100篇 |
1995年 | 87篇 |
1994年 | 66篇 |
1993年 | 60篇 |
1992年 | 52篇 |
1991年 | 42篇 |
1990年 | 40篇 |
1989年 | 37篇 |
1988年 | 24篇 |
1987年 | 40篇 |
1986年 | 31篇 |
1985年 | 33篇 |
1984年 | 49篇 |
1983年 | 46篇 |
1982年 | 53篇 |
1981年 | 58篇 |
1980年 | 73篇 |
1979年 | 38篇 |
1978年 | 33篇 |
1977年 | 21篇 |
1976年 | 24篇 |
1975年 | 22篇 |
1974年 | 27篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
Faivre L Dollfus H Lyonnet S Alembik Y Mégarbané A Samples J Gorlin RJ Alswaid A Feingold J Le Merrer M Munnich A Cormier-Daire V 《American journal of medical genetics. Part A》2003,(2):204-207
Weill-Marchesani syndrome (WMS) is a rare condition characterized by short stature, brachydactyly, joint stiffness, and characteristic eye abnormalities including microspherophakia, ectopia of lens, severe myopia, and glaucoma. Both autosomal recessive (AR) and autosomal dominant (AD) modes of inheritance have been described for WMS. A locus for AR WMS has recently been mapped to chromosome 19p13.3-p13.2 while mutation within the fibrillin-1 gene (15q21.1) was found in one AD WMS family. In order to answer the question of whether or not genetic heterogeneity could be related to a clinical heterogeneity, we reviewed 128 WMS patients from the literature (including 57 AR, 50 AD, and 21 sporadic cases), with a particular attention to clinical features. Statistical analyses using Fischer exact test were used to compare the proportions of 12 clinical parameters between AR and AD patients. There was no significant difference between both groups for myopia, glaucoma, cataract, short stature, brachydactyly, thick skin, muscular build, and mental retardation. Significant results were found for microspherophakia (94% in AR, 74% in AD, Fischer 0.007), ectopia lentis (64% in AR, 84% in AD, Fischer 0.016), joint limitations (49% in AR, 77% in AD, Fischer 0.010), and cardiac anomalies (39% in AR, 13% in AD, Fischer 0.004). Nevertheless, we failed to distinguish AR from AD inheritance in individual cases. These results support the clinical homogeneity but the genetic heterogeneity of WMS. 相似文献
62.
63.
64.
The primary interest of our laboratory is understanding how the signals that a T cell receives influence its behavior during
an immune response. Recently, we have focused our attention on the examination of T cell responses at an individual cell level.
This article outlines our approach, presents our initial findings, and discusses the implications of these findings relative
to our current models of T cell activation. 相似文献
65.
Hoza B Gerdes AC Hinshaw SP Arnold LE Pelham WE Molina BS Abikoff HB Epstein JN Greenhill LL Hechtman L Odbert C Swanson JM Wigal T 《Journal of consulting and clinical psychology》2004,72(3):382-391
The self-perceptions of children with attention-deficit/hyperactivity disorder (ADHD; n = 487) were compared with those of children in a local normative comparison group (n = 287), relative to teacher- and parent-rated perceptions of their competence. Children were participants in the ongoing follow-up portion of the Multimodal Treatment Study of Children with ADHD. Children with ADHD were much more likely than comparison children to overestimate their competence relative to adult report, regardless of who was used as the criterion rater (teacher, mother, or father). Examination by comorbidity subgroups revealed that children with ADHD inflated their self-perceptions the most in domains of greatest deficit. Gender effects also are reported. 相似文献
66.
67.
68.
69.
Jocelyne Fleury-Feith Laurence Kheuang Lin Zeng Jean Bignon Christian Boutin Isabelle Monnet Marie-Claude Jaurand 《The Journal of pathology》1995,177(2):209-215
The aim of this study was to determine, by transmission electron microscopy, the differentiation features of 21 human malignant mesothelioma cell lines (HMCLs) established from 13 specimens of 12 confirmed human malignant mesotheliomas, and of tumours induced in nude mice injected with 16 HMCLs. Fifty per cent of HMCLs showed typical mesothelial differentiation (long and slender microvilli, desmosomes, perinuclear intermediate filaments); 29 per cent did not show differentiation; and the remainder were poorly differentiated. Three human tumour specimens gave several different HMCLs; the cell lines obtained from a given tumour exhibited variable mesothelial differentiation. Eleven HMCLs were compared with the native tumour. Four were similar to the tumour and seven were less well differentiated, in most cases in relation to their microvilli. With six HMCLs, tumours induced in nude mice were less well differentiated than the corresponding cell lines, whereas with four HMCLs, tumours were equally or better differentiated. However, in most nude mice tumours, typical mesothelial microvilli were present. These results show that cell lines established from malignant mesothelioma may exhibit dedifferentiated features. However, while the variability in ultrastructural differentiation may result from the culture microenvironment, it could also be related to the state of differentiation, of the native tumour sample and to tumour cell heterogeneity. 相似文献
70.
Colombet I Aguirre-Junco AR Zunino S Jaulent MC Leneveut L Chatellier G 《International journal of medical informatics》2005,74(7-8):597-604
Despite initiatives to standardize methods for the development of clinical guidelines, several barriers hinder their integration in daily clinical practice: failure to fulfil quality criteria, poor effectiveness of their dissemination. Computerization of guidelines can favor their dissemination. The initial step of computerization is the knowledge specification from the text of the guideline. We describe the method of knowledge specification, which is used in EsPeR (Personalized Estimate of Risks), a web-based decision support system in preventive medicine, which allows, for a given person, to estimate risks and access recommendations, based on clinical profile. This method is based on a structured and systematic analysis of text allowing detailed specification of a decision tree. We use decision tables to validate the decision algorithm and decision trees to specify this algorithm, along with elementary messages of recommendation. Editing tools are used to facilitate the process of validation and the workflow between expert physicians and computer scientists. Applied to eleven different guidelines, the method allows a quick and valid computerization and integration in the EsPeR system. The method used for computerization could help to define a framework usable at the initial step of guideline development in order to produce guidelines ready for electronic implementation. 相似文献