全文获取类型
收费全文 | 7294篇 |
免费 | 469篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 174篇 |
妇产科学 | 123篇 |
基础医学 | 730篇 |
口腔科学 | 158篇 |
临床医学 | 762篇 |
内科学 | 1542篇 |
皮肤病学 | 64篇 |
神经病学 | 511篇 |
特种医学 | 903篇 |
外科学 | 1035篇 |
综合类 | 132篇 |
一般理论 | 2篇 |
预防医学 | 661篇 |
眼科学 | 87篇 |
药学 | 369篇 |
2篇 | |
中国医学 | 3篇 |
肿瘤学 | 471篇 |
出版年
2021年 | 86篇 |
2020年 | 57篇 |
2019年 | 86篇 |
2018年 | 123篇 |
2017年 | 86篇 |
2016年 | 84篇 |
2015年 | 108篇 |
2014年 | 162篇 |
2013年 | 228篇 |
2012年 | 363篇 |
2011年 | 341篇 |
2010年 | 195篇 |
2009年 | 198篇 |
2008年 | 288篇 |
2007年 | 336篇 |
2006年 | 294篇 |
2005年 | 286篇 |
2004年 | 282篇 |
2003年 | 225篇 |
2002年 | 207篇 |
2001年 | 196篇 |
2000年 | 202篇 |
1999年 | 178篇 |
1998年 | 130篇 |
1997年 | 115篇 |
1996年 | 123篇 |
1995年 | 105篇 |
1994年 | 82篇 |
1993年 | 99篇 |
1992年 | 155篇 |
1991年 | 143篇 |
1990年 | 181篇 |
1989年 | 199篇 |
1988年 | 178篇 |
1987年 | 178篇 |
1986年 | 177篇 |
1985年 | 164篇 |
1984年 | 122篇 |
1983年 | 98篇 |
1982年 | 68篇 |
1981年 | 61篇 |
1980年 | 73篇 |
1979年 | 58篇 |
1978年 | 75篇 |
1977年 | 59篇 |
1976年 | 59篇 |
1975年 | 43篇 |
1974年 | 52篇 |
1973年 | 46篇 |
1972年 | 44篇 |
排序方式: 共有7791条查询结果,搜索用时 15 毫秒
81.
82.
83.
84.
85.
H Preisler A Raza R Larson J Goldberg G Tricot M Carey C Kukla 《Leukemia research》1991,15(9):773-780
The failure of three consecutive treatment protocols to significantly increase the complete remission rate for poor prognosis newly diagnosed patients with acute myelocytic leukemia led to a detailed investigation of the causes of treatment failure. In the majority of cases treatment failure was attributable to "clinical resistance" to therapy. Upon close examination two types of "clinical resistance" were discernible: the failure of chemotherapy to produce adequate cytotoxic effects ("classical" drug resistance), and treatment failure attributed to the rapid regrowth of leukemia cells subsequent to the substantial killing of leukemia cells by cytotoxic therapy ("biological" resistance). Each form of resistance accounted for one-half of the treatment failures. 相似文献
86.
87.
Benzodiazepines are one of the most frequently prescribed classes of medications in the world. Thought to relieve the symptoms of anxiety, insomnia, epilepsy, and some less common conditions, these medications are supported by a body of clinical trials demonstrating efficacy. However, there is also literature that suggests problems of abuse and dependence, along with some serious adverse effects. The present article utilises a value-analysis strategy to outline the clinical efficacy and economic efficiency of benzodiazepines from a variety of perspectives including those of the patient, physician and manufacturer. Results of this analysis suggest that these medications are effective when used appropriately, but that implementation of appropriate use is difficult. Remedies to this situation are discussed. 相似文献
88.
S M Larson J A Carrasquillo D C Colcher K Yokoyama J C Reynolds S A Bacharach A Raubitchek L Pace R D Finn M Rotman 《Journal of nuclear medicine》1991,32(9):1661-1667
Using a newly available model for determining estimates of radiation absorbed dose of radioisotopes administered intraperitoneally, we have calculated absorbed dose to tumor and normal tissues based on a surgically controlled study of radiolabeled antibody distribution. Ten patients with peritoneal carcinomatosis received intraperitoneal injections of the murine monoclonal antibody B72.3 radiolabeled with 131I. Biodistribution studies were performed using nuclear medicine methods until laparotomy at 4-14 days after injection. Surgical biopsies of normal tissues and tumor were obtained. The marrow was predicted to be the critical organ, with maximum tolerated dose [200 rad (2 Gy) to marrow] expected at about 200 mCi (7.4 GBq). In patients with large intraperitoneal tumor deposits, the tumor itself is an important source tissue for radiation exposure to normal tissues. Local "hot-spots" for tumor-absorbed dose were observed, with maximum tumor-absorbed dose calculated at 11,000 rad (11 Gy) per 100 mCi (3.7 GBq) administered intraperitoneal; however, tumor rad dose varied considerably. This may pose serious problems for curative therapy, especially in patients with large tumor burdens. 相似文献
89.
Methods of controlling controlled substance (CS) inventories in unit dose dispensing systems vary. The two extremes are total floor stock of all CS drugs by the use of declining inventory signout sheets on the nursing unit to controlling only Class II and a few selected class III-V items. The method described herein outlines a systematic approach to controlling items on an individual patient basis consistant with the benefits of unit dose dispensing. A CS card assigned to each patient for each of his required controlled substance medications serves as an audit trail for doses consumed by the patient and provides a declining inventory receipt when returned to the pharmacy. 相似文献
90.
T E Davis L Kahan D C Tormey F C Larson S A Anderson J J Crowley R N Carey 《Cancer research》1981,41(3):1110-1113
The activity of an isoenzyme of alkaline phosphatase (FHAP) was measured in serum samples obtained from 1692 individual subjects. The median FHAP concentration in patients with untreated or recurrent cancer (2.73 IU/liter) was two-fold higher than in hospitalized control patients with illnesses other than cancer (1.17 IU/liter) and three-fold higher than in healthy control subjects (0.93 IU/liter). Among patients with either breast or colorectal cancer who were clinically disease free following their initial therapy, the median FHAP concentration (1.54 IU/liter) was intermediate between the median FHAP concentration in patients with untreated or recurrent cancer and that of healthy control subjects. In order to illustrate the potential clinical application of FHAP as a diagnostic cancer marker, we have selected a serum FHAP concentration of 2.22 IU/liter as a reference value above which only 3% of healthy control subjects would have a "positive" test. Utilizing this reference value, 58% of the patients in the present study with untreated or recurrent cancer would have a positive FHAP test, whereas only 11%, of hospitalized patients with illnesses other than cancer would have a positive test. These data suggest that FHAP may be equivalent to the carcinoembryonic antigen as a diagnostic cancer marker. 相似文献