手法复位后不同年龄阶段髋臼发育的形态学变化

目的:观察手法复位后不同年龄阶段发育性髋关节脱位患儿髋臼发育的形态学变化。方法:⑴试验对象:选择2001-01/2005-09山东中医药大学附属医院和泰山医学院附属医院发育性髋关节脱位患者156例。纳入标准:①符合本病诊断标准者。②年龄<3岁。③髋关节半脱位及Ⅰ、Ⅱ度脱位,但髋关节内收肌不太紧张;Ⅲ度必须行牵引后股骨头降至髋臼的水平;Ⅳ度必须为一次复位成功且⑥患者家属对本试验知情同意。髋关节周围软组织不紧张者。④2～3岁髋脱位的髋臼指数<45°,前倾角≤60°。⑤内收肌严重挛缩的必须行内收肌切断术。排除标准:合并心、脑血管和造血系统等严重原发性疾病、精神病患者,肝、肾功能检查异常者。⑵试验方法:将所选病例分为<1岁组、1～2岁组和2～3岁组,采用手法闭合复位铝支架固定动态治疗发育性髋关节脱位,进行18个月的随访观察。⑶试验评估:观察治疗前、治疗后6,12,18个月的X射线片,测量髋臼指数的动态变化,并分析疗效。结果:纳入髋关节脱位患者156例,随访中脱落18例,最终进入统计病例138例,随访率为88.5%。随访中发现7例出现再脱位,经过手术治疗治愈,总体优良率达92.1%。各年龄组患侧髋臼指数平均由34.21°、34.54°和37.21°减少至22.32°、24.66°、26.64°,平均每月减少0.65°、0.61°和0.52°,差异有显著性意义(P<0.01),优良率分别为95%、87%和75%,且各年龄组患侧髋臼指数的下降与其治疗时基数起点有关。结论:对发育性髋关节脱位采用手法复位铝板支架塑形固定动态治疗可促进髋臼发育,其疗效与年龄因素关系密切,起始治疗时年龄越小效果越好。     

Mésothéliome malin primitif du péritoine

Introduction

Peritoneal mesothelioma is a rare disease. Its diagnosis is difficult. It is based on immunohistochemical study. Its symptoms are non specific. Treatment suffers from the lack of standard therapy. Prognosis remains moderate especially with the trials cytoreductive surgery associated with intraperitoneal chemotherapy. We report the case of a patient followed at the medical oncology department of the university hospital Hassan II of Fez.

Patient and observation

A 54 years-old patient had a progressive increase in abdominal volume evolving in a context of deterioration of general condition, clinical and radiological examination found an ascitis with peritoneal thickening, and the diagnosis of primary malignant mesothelioma of the peritoneum was confirmed by immunohistochemical study.

Conclusion

Malignant peritoneal mesothelioma is a rare tumor, which suffer from the lack of a standard treatment hence the need of a multidisciplinary approach and the inclusion of patients in clinical trials.     

用MUG-Indole法和药典法对大肠杆菌变异情况考察

目的：通过ＭＵＧ－Ｉｎｄｏｌｅ法和中国药典法对大肠杆菌变异情况考察,选出较优的大肠杆菌检验方法,方法：ＭＵＧ－Ｉｎｄｏｌｅ法和中国药典法配对试验,结果：两法无显著性差异。结论ＭＵＧ－Ｉｎｄｏｌｅ法优于中国药典法。     

雷公藤酮的结构

从雷公藤(Tripterygium wilfordii)根心中分到三个三萜化合物(Ⅰ,Ⅱ,Ⅲ),经光谱数据分析,确定Ⅲ为一个新的木栓烷类衍生物,命名为雷公藤酮,化学名为3-hydroxy-25-norfriedel-3,1(10)-dien-2-one-30-oic acid.Ⅰ为3β,22β-dihydroxy-△¹²-oleanen-29-oic acid,Ⅱ为2a,3a,24-trihydroxy-△¹²-ursene-28-oic acid,系首次从雷公藤属植物中分离得到。     

Thrombolyse postopératoire immédiate dans un contexte d’accident vasculaire sylvien gauche

Intravenous thrombolytic therapy for ischemic stroke was performed on a 75-year-old patient at recovery from cervicocephalic superficial surgery. The patient recovered totally from ischemic stroke and no neurologic sequelae was observed. Thrombolytic therapy must be performed in an intensive care unit in order to manage some bleeding events which can occur.     

天然有机化合物质谱研究——Ⅺ.苯丙型苷快原子轰击质谱MNa~+的MIKES谱

研究了六种苯丙型苷与Na~+加合离子的快原子轰击质谱(FAB—MS)和质量分离离子动能谱(MIKES)。结果表明:在FAB谱中[M+Na]~+加合离子的丰度要比[M+H]~+离子高得多。由此可给出糖苷的分子量信息,[M+Na]~+离子的MIKES谱可给出糖基序列信息。     

6-氟喹诺酮类衍生物的合成及抗菌活性

报道一系列7,8-双取代的1-环丙基和1-乙基-6-氟-1,4-二氢-4-氧-3-喹啉羧酸衍生物的合成和体外抗菌活性。其中,1-环丙基-6-氟-7-(4-乙酰氧基哌啶)-8-氯-1,4-氢-4-氧-3-喹啉羧酸(11c)和1-环丙基-6-氟-7-(4-羟基哌啶)-8-氯-1,4-二氢-4-氧-3-喹啉羧酸(11b)同环丙沙星相比有更强的体外活性,尤其对金黄色葡萄球菌、耐甲氧青霉素金葡菌(MRSA)和绿脓杆菌。     

上颈椎三维有限元模型的建立

目的:建立上颈椎三维有限元模型,以期应用于临床相关的生物力学实验研究中。方法:实验于2005-05/2006-01在南方医科大学解剖及生物力学实验室完成。选取2例自愿参与实验的健康青年男性,均经医院伦理委员会批准,且受试者知情同意。复习病史并行X射线平片检查排除枕颈部疾患。通过对正常人的CT薄层扫描获得原始DICOM图像数据,采用CAD数据处理技术进行计算机三维重建,改良建立的模型导入ANSYS9.0软件进行计算机模拟仿真生物力学研究。结果:所建模型外观清晰逼真,几何相似性好。所建的上颈椎有限元模型能够通过验证,与体外生物力学实验结果基本吻合,可进一步行各种上颈椎有限元力学分析。结论:为临床对枕颈交界区有限元三维模型的建立提供了一种便捷而精确的方法,对计算机分析及研究该模型局部结构在各种受力情况下的生物力学表现创造条件。     

Central cholinergic depletion induced by 192 IgG-Saporin alleviates the sedative effects of propofol in rats

We examined the effect of central cholinergic depletion on thesedative potency of propofol in rats. Depletion was producedby intracerebroventricular administration of an immunotoxinspecific to cholinergic neurones (192 IgG-Saporin; 2 µg).As a result of this lesion, acetylcholine concentration wasreduced by about 40% in the frontoparietal cortex and in thehippocampus but was essentially normal in the striatum and cerebellum.Sedation in rats was assessed as the decrease in locomotor activity.Sedative potency of propofol (30 mg kg^–1 i.p.) was reducedby about 50% in rats who received the injection of 192 IgG-Saporinas compared to controls. These results show that a central cholinergicdepletion alleviates the sedative effect of propofol, and indicatesthat basal forebrain cholinergic neurones might mediate partof the sedative/hypnotic effects of propofol. Br J Anaesth 2000; 85: 869–73