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71.
Karen G Peres Marco A Peres Cora LP Araujo Ana MB Menezes Pedro C Hallal 《Health and quality of life outcomes》2009,7(1):95
Background
Harmful social conditions in early life might predispose individuals to dental status which in turn may impact on adolescents' quality of life. 相似文献72.
Panagiotis Alexopoulos MD Florian Günther Cand Med Julius Popp MD Frank Jessen MD Oliver Peters MD Stefanie Wolf LP Thomas Kneib PhD Alexander Kurz MD Tanja Richter-Schmidinger LP Piotr Lewczuk MD Stefan Bleich MD Jens Wiltfang MD Johannes Kornhuber MD 《Journal of the American Geriatrics Society》2009,57(4):737-739
73.
BO Taiwo X Li F Palella LP Jacobson JB Margolick R Detels CR Rinaldo JP Phair 《HIV medicine》2009,10(10):657-660
Background The clinical implications of a failure to achieve high CD4 cell counts while receiving virally suppressive highly active antiretroviral therapy (HAART) are uncertain.
Methods We analysed data from HIV-infected men participating in the Multicenter AIDS Cohort Study (MACS) to elucidate associations between CD4 cell counts achieved during virally suppressive HAART and risks of AIDS or death. Inclusion criteria were: CD4 cell count <200 cells/μL before HAART initiation; ≥2 viral load (VL) determinations after HAART initiation; and sustained viral suppression, defined as all VL <50 HIV-1 RNA copies/mL, but allowing a single VL of 50–1000 copies/mL.
Results One hundred and twenty-one men were included; median age was 42 years. After first VL <50 copies/mL, six participants had a new AIDS diagnosis and seven died. The median CD4 cell count change/year (cells/μL) after first VL <50 copies/mL was zero among patients who either developed AIDS or died vs . 39 among those who did not meet either endpoint ( P =0.119). After controlling for time from HAART initiation to first VL <50 copies/mL, age at first VL <50 copies/mL, history of AIDS and antiretroviral therapy (ART) experience before HAART, the hazard ratio for AIDS or death at CD4 cell count of ≤200 vs . >350 cells/μL was 10.7 ( P =0.013), and at CD4 cell count of 201–350 vs . >350 cells/μL was 8.54 ( P =0.014).
Conclusion In this cohort, lower CD4 cell count at the time of viral suppression was associated with increased risk of AIDS or death. 相似文献
Methods We analysed data from HIV-infected men participating in the Multicenter AIDS Cohort Study (MACS) to elucidate associations between CD4 cell counts achieved during virally suppressive HAART and risks of AIDS or death. Inclusion criteria were: CD4 cell count <200 cells/μL before HAART initiation; ≥2 viral load (VL) determinations after HAART initiation; and sustained viral suppression, defined as all VL <50 HIV-1 RNA copies/mL, but allowing a single VL of 50–1000 copies/mL.
Results One hundred and twenty-one men were included; median age was 42 years. After first VL <50 copies/mL, six participants had a new AIDS diagnosis and seven died. The median CD4 cell count change/year (cells/μL) after first VL <50 copies/mL was zero among patients who either developed AIDS or died vs . 39 among those who did not meet either endpoint ( P =0.119). After controlling for time from HAART initiation to first VL <50 copies/mL, age at first VL <50 copies/mL, history of AIDS and antiretroviral therapy (ART) experience before HAART, the hazard ratio for AIDS or death at CD4 cell count of ≤200 vs . >350 cells/μL was 10.7 ( P =0.013), and at CD4 cell count of 201–350 vs . >350 cells/μL was 8.54 ( P =0.014).
Conclusion In this cohort, lower CD4 cell count at the time of viral suppression was associated with increased risk of AIDS or death. 相似文献
74.
V Wewer KM Christiansen LP Andersen FW Henriksen JP Hart Hansen M Tvede PA Krasilnikoff 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(12):1276-1281
Helicobacter pylori was cultured and Helicobacter-like organisms (HLO) were seen in 6 (16%) of 37 children with recurrent abdominal pain. Five children had concomitant histological inflammation, but none had endoscopic changes. All 6 children demonstrated positive serology. Compared with the total group, they were more often from developing countries, larger families and lower Social groups. Treatment with phenoxymethyl penicillin and colloidal bismuth subcitrate did not result in side effects or elevated serum levels of serum bismuth. Three children demonstrated metronidazole-resistant strains and the treatment of these children remained an unsolved problem. Among the 31 H. pylori/ HLO negative children 8 (26%) demonstrated histological changes, 5 (16%) endoscopic changes and 11 (35%) had positive serology. In conclusion, pathological findings at upper gastrointestinal endoscopy are common in children with recurrent abdominal pain. Because of disconcordance between endoscopy, histology and culture, we recommend that biopsies should always be taken to clarify the diagnosis. 相似文献
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Gina Dimitropoulos PhD RSW FAED Manya Singh MEd Jessica Sauerwein BSW Pardis Pedram MD PhD Melissa Kimber PhD MSW RSW Martin Pradel McFT Sarah Eckhardt LP PhD Sarah Forsberg PsyD Helene Keery LP PhD Erica Allan MPsych Lindsey Bruett PhD Daniel Le Grange PhD FAED 《The International journal of eating disorders》2024,57(3):635-647
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80.
二苯乙烯类化合物对蛋白激酶C的抑制作用 总被引:14,自引:0,他引:14
报道15种二苯乙烯类化合物对蛋白激酶C(PKC)活性的影响。其中从中药金雀根中分得的3种二苯乙烯类低聚体α-viniferin,kobophenol A 和 miyabenolC,它们抑制PKC的IC50分别为62.5,52.0和27.5μmol·L-1。另外6种含酚羟基的二苯乙烯化合物对PKC也显示不同程度的抑制作用,但当酚羟基全甲基化或全乙酰化后其抑制作用大大降低甚至消失。酶动力学研究证明miyabenolC对PKC的抑制作用属于非竞争性抑制。 相似文献