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排序方式: 共有555条查询结果,搜索用时 46 毫秒
91.
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93.
Toshihide Kubo Mahoko Furujo Kyohei Takahashi Yuki Hyodo Hiroki Tsuchiya Mariko Hattori Shoko Fujinaga Kenji Urayama 《Indian journal of pediatrics》2018,85(4):261-265
Objectives
To assess the effects of growth hormone (GH) on lipid profiles in children and whether the effect is pharmacological.Methods
The authors determined serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and low-density lipoprotein cholesterol (LDL-C) every year during 3-y GH treatment in 48 GH deficient (GHD) short children and 22 children with short stature born small for gestational age (SGA).Results
The abnormally high levels of TC, non-HDL-C, and LDL-C showed a high frequency in GHD short children compared with epidemiological studies in Japan. The high prevalence of high level of TC was also shown in SGA short children. Three-year GH treatment decreased serum TC, non-HDL-C, and LDL-C levels in both patient groups.Conclusions
GH treatment is clearly a pharmacological therapy in SGA short children and so may also be in GHD short children at the Japanese standard therapeutic dose. Taken together, GH improves lipid profiles, and its effect has the possibility of medical properties.94.
Curcuma sp.‐derived dehydrocurdione induces heme oxygenase‐1 through a Michael reaction between its α, β‐unsaturated carbonyl and Keap1
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95.
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Kyohei Hakozaki Eiji Kikuchi Keishiro Fukumoto Suguru Shirotake Yasumasa Miyazaki Takahiro Maeda Gou Kaneko Shunsuke Yoshimine Nobuyuki Tanaka Kunimitsu Kanai Masafumi Oyama Yosuke Nakajima Tetsuo Momma Mototsugu Oya 《Medical oncology (Northwood, London, England)》2017,34(12):187
Although the clinical utility of a frozen section analysis (FSA) at the time of radical cystectomy (RC) has already been established, its significance and utility in bladder cancer patients receiving neoadjuvant chemotherapy (NAC) have not yet been fully evaluated. We identified 458 patients (937 ureters) who underwent open RC for bladder cancer at our 7 Japanese institutions between 2004 and 2015. Among these patients, 139 (284 ureters) received NAC before RC (NAC group), while 319 (653 ureters) underwent RC alone (non-NAC group). FSA was performed on 356 out of 937 (38.0%) ureters and 179 out of 458 (39.1%) patients. FSA was positive in 30 out of 356 (8.4%) ureters and its sensitivity, specificity, and accuracy were 89.3, 98.5, and 97.8%, respectively. In the NAC group, FSA was performed on 138 out of 284 (48.6%) ureters and 68 out of 139 (48.9%) patients. FSA was positive in 8 out of 138 ureters (5.8%), and its sensitivity, specificity, and accuracy were 77.8, 99.2, and 97.8%, respectively. In the non-NAC group, FSA was performed on 218 out of 653 (33.4%) ureters and 111 out of 319 (34.8%) patients. FSA was positive in 22 out of 218 (10.1%) ureters, and its sensitivity, specificity, and accuracy were 94.7, 98.0, and 97.7%, respectively. No correlation was observed between preoperative clinical factors and FSA positivity in the NAC group; however, in the non-NAC group, the incidence of FSA positivity in the ureters of patients with concomitant CIS in TUR-BT specimens was 8/41 (19.5%), which was significantly higher than that in their counterpart (14/177, 7.9%, p = 0.033). Even in the era of NAC in the management of bladder cancer patients, the performance of FSA does not change and FSA at the time of RC may provide useful diagnostic information. 相似文献
97.
Masanobu Ohya Kazushige Kadota Mamoru Toyofuku Takeshi Morimoto Hirooki Higami Yasushi Fuku Kyohei Yamaji Hiromi Muranishi Yuhei Yamaji Koji Nishida Daisuke Furukawa Tomohisa Tada Euihong Ko Kenji Ando Hiroki Sakamoto Takashi Tamura Kazuya Kawai Takeshi Kimura 《The American journal of cardiology》2017,119(3):355-364
98.
99.
Keiko Takahashi Mitsumasa Ohyanagi Kiyomitsu Ikeoka Miho Masai Hitoshi Naruse Tadaaki Iwasaki Minoru Fukuchi Takashi Miyamoto 《Journal of nuclear cardiology》2001,8(2):165-170
BACKGROUND: The exact cause of aortic aneurysms is not completely understood. Histologically, the atherosclerotic lesions present in an aneurysm contain numerous inflammatory cells. This finding represents active atherosclerosis, which can cause lesion expansion. In this study we investigated the role of scintigraphy in the evaluation of inflammation in aortic aneurysms. METHODS AND RESULTS: We performed imaging using indium 111-oxine--labeled leukocytes in 14 patients with aortic aneurysms (10 thoracic and 4 abdominal) diagnosed by computed tomography. Peripheral blood evidence of inflammation was assessed on the same day. In 8 patients who subsequently underwent graft replacement of the aneurysm, the excised specimen was examined for evidence of inflammatory infiltration and correlated with the scintigraphic findings. Scintigraphic accumulation of labeled leukocytes was present in 10 of the 14 patients. Although all patients had a small increase in the erythrocyte sedimentation rate, there was no significant difference in the erythrocyte sedimentation rate between patients with positive and negative scintigram results. In 5 of the 8 surgical patients with positive scintigram results, the resected specimens demonstrated numerous inflammatory cells in the adventitia of the aortic wall and atherosclerotic changes in the media. There was no correlation between the presence of periaortic inflammatory adhesions at the time of surgery and the scintigraphic results. CONCLUSIONS: The accumulation of In-111-oxine--labeled leukocytes is a potentially useful scintigraphic marker of inflammatory infiltration in aortic aneurysms. 相似文献
100.
Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) 总被引:12,自引:0,他引:12
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Hitoshi Hashimoto Norihito Shintani Kazuhiro Tanaka Wakaba Mori Megumi Hirose Toshio Matsuda Masaki Sakaue Jun-ichi Miyazaki Hitoshi Niwa Fumi Tashiro Kyohei Yamamoto Kazumi Koga Shuhei Tomimoto Akiyoshi Kunugi Sayoko Suetake Akemichi Baba 《Proceedings of the National Academy of Sciences of the United States of America》2001,98(23):13355-13360
Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably during evolution and is widely expressed in the mammalian brain. In Drosophila, mutation of the PACAP homologue results in behavioral defects, including impaired olfaction-associated learning and changes in ethanol sensitivity. Here, we report the generation of mice lacking the PACAP gene (PACAP(-/-)). PACAP(-/-) mice were born in the expected Mendelian ratios but had a high early-mortality rate. The surviving adult PACAP(-/-) mice displayed remarkable behavioral changes; they exhibited hyperactive and explosive jumping behaviors in an open field, increased exploratory behavior, and less anxiety in the elevated plus maze, emergence, and novel-object tests. Analysis of PACAP(-/-) mice brains revealed that the serotonin metabolite 5-hydroxyindoleacetic acid was slightly decreased in the cortex and striatum compared with wild-type mice. The present study provides evidence that PACAP plays a previously uncharacterized role in the regulation of psychomotor behaviors. 相似文献