全文获取类型
收费全文 | 11403篇 |
免费 | 708篇 |
国内免费 | 128篇 |
专业分类
耳鼻咽喉 | 199篇 |
儿科学 | 76篇 |
妇产科学 | 137篇 |
基础医学 | 2094篇 |
口腔科学 | 326篇 |
临床医学 | 948篇 |
内科学 | 1865篇 |
皮肤病学 | 455篇 |
神经病学 | 1044篇 |
特种医学 | 639篇 |
外科学 | 1571篇 |
综合类 | 35篇 |
一般理论 | 2篇 |
预防医学 | 465篇 |
眼科学 | 278篇 |
药学 | 1238篇 |
中国医学 | 151篇 |
肿瘤学 | 716篇 |
出版年
2024年 | 7篇 |
2023年 | 77篇 |
2022年 | 292篇 |
2021年 | 477篇 |
2020年 | 200篇 |
2019年 | 304篇 |
2018年 | 361篇 |
2017年 | 282篇 |
2016年 | 391篇 |
2015年 | 502篇 |
2014年 | 652篇 |
2013年 | 730篇 |
2012年 | 1043篇 |
2011年 | 980篇 |
2010年 | 623篇 |
2009年 | 529篇 |
2008年 | 743篇 |
2007年 | 729篇 |
2006年 | 644篇 |
2005年 | 558篇 |
2004年 | 446篇 |
2003年 | 384篇 |
2002年 | 314篇 |
2001年 | 218篇 |
2000年 | 188篇 |
1999年 | 129篇 |
1998年 | 61篇 |
1997年 | 47篇 |
1996年 | 31篇 |
1995年 | 28篇 |
1994年 | 20篇 |
1993年 | 18篇 |
1992年 | 35篇 |
1991年 | 31篇 |
1990年 | 32篇 |
1989年 | 23篇 |
1988年 | 16篇 |
1987年 | 16篇 |
1986年 | 9篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1979年 | 7篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1969年 | 2篇 |
1968年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Pharmacokinetic and pharmacodynamic modeling of the antiplatelet and cardiovascular effects of cilostazol in healthy humans 总被引:11,自引:0,他引:11
OBJECTIVE: Cilostazol is an antiplatelet agent with vasodilating properties. It has been used to treat patients with peripheral ischemia, such as intermittent claudication. We used a pharmacokinetic-pharmacodynamic model to analyze the relation between the plasma concentration of cilostazol, the inhibitory effect of the drug on platelet aggregation, and the cardiovascular effects of the drug on healthy humans. METHODS: A single oral dose of 100 mg cilostazol was administered to 20 healthy volunteers. Serial blood sampling and pharmacodynamic measurements were performed up to 48 hours thereafter. The effects of cilostazol on platelet aggregation, blood pressure, and heart rate were measured during the same period. The plasma concentration of cilostazol was measured with a validated HPLC method that entailed ultraviolet detection. The time courses of plasma cilostazol concentration, platelet aggregation, and cardiovascular effects were analyzed by means of pharmacokinetic-pharmacodynamic modeling with the program ADAPT II. RESULTS: The plasma concentration-time course followed a 2-compartment model. Mean peak concentration was 775 ng/ml approximately 3.65 hours after administration of cilostazol. The maximal effect on platelet aggregation was a 31.14% reduction 6.05 hours after administration. No significant difference in systolic blood pressure was found. The maximal increase in heart rate was 13.49%, whereas the maximal decrease in diastolic blood pressure was 29.51%. Both peak effects were detected approximately 6 hours after administration of the drug. Platelet aggregation and cardiovascular effects (change in diastolic blood pressure and heart rate) were analyzed with the effect-link sigmoid maximal effect model. CONCLUSION: This pharmacokinetic-pharmacodynamic model successfully described the relation between plasma concentration of cilostazol and the antiplatelet and cardiovascular effects of the drug. 相似文献
992.
Um JH Kwon JK Kang CD Kim MJ Ju DS Bae JH Kim DW Chung BS Kim SH 《The Journal of pharmacology and experimental therapeutics》2004,311(3):1062-1070
The failure to treat metastatic cancer with multidrug resistance is a major problem for successful cancer therapy, and the molecular basis for the association of metastatic phenotype with resistance to therapy is still unclear. In this study, we revealed that various metastatic cancer cells showed consistently higher levels of antiapoptotic proteins, including Bcl-2, nuclear factor-kappaB, MDM2, DNA-dependent protein kinase (DNA-PK), and epidermal growth factor receptor (EGFR), and lower levels of proapoptotic proteins, including Bax and p53 than low metastatic parental cells. This was followed by chemo- and radioresistance in metastatic cancer cells compared with their parental cells. EGFR and DNA-PK activity, which are known to be associated with chemo- and radioresistance, were demonstrated to be mutually regulated by each other. Treatment with PKI166, an EGFR inhibitor, suppressed etoposide-induced activation of DNA-PK in A375SM metastatic melanoma cells. In addition, PKI166 enhanced markedly the chemosensitivities of metastatic cancer cell sublines to various anticancer drugs in comparison with those of low metastatic cancer cells. These results suggest that the activities of DNA-PK and EGFR, which is positively correlated with each other, may contribute to metastatic phenotype as well as therapy resistance, and the EGFR inhibitor enhances the effect of anticancer drugs against therapy-resistant metastatic cancer cells via suppression of stress responses, including activation of DNA-PK. 相似文献
993.
994.
995.
996.
Eric J. May Lyndsay D. Viers Boyd R. Viers Akira Kawashima Eugene D. Kwon R. Jeffrey Karnes Adam T. Froemming 《Abdominal imaging》2016,41(5):862-876
Recurrent prostate cancer following primary treatment is common, and the population of men with biochemical recurrence is complex. Conventional management of recurrent prostate cancer involves nontargeted and/or systemic therapies, without defining an individual patient’s specific disease. However, recent advances in imaging enable a shift in the management of recurrent prostate cancer to targeted, patient-specific approaches. Specifically, MRI can detect and define local prostate cancer recurrence early in the course of disease, and prostate-specific PET imaging greatly improves nodal staging and can detect previously unknown distant metastases. The significant advances in the imaging of both local and distant tumor recurrences allows for specific selection of treatment options tailored to patients and their disease with less associated morbidity. 相似文献
997.
Analytical Performance Evaluation of Infopia Element™ Auto‐coding Blood Glucose Monitoring System for Self‐Monitoring of Blood Glucose 下载免费PDF全文
998.
Incidence and patterns of cardiomyopathy in carbon monoxide-poisoned patients with myocardial injury
Yong Sung Cha Sung Oh Hwang Jang Young Kim Yun Kwon Kim Eun Hee Choi 《Clinical toxicology (Philadelphia, Pa.)》2016,54(6):481-487
Objectives: Sustained myocardial injury is a significant predictor of mortality in carbon monoxide (CO) poisoning. There are few reports in the literature regarding the presence of CO-induced cardiomyopathy from early stages in the emergency department (ED). We prospectively investigated the early incidence of CO-induced cardiomyopathy and its patterns in patients with cardiomyopathy. Materials and methods: During a 10-month period, transthoracic echocardiography (TTE) was performed in 43 consecutive patients with CO poisoning and myocardial injury, which was defined as elevated high-sensitive troponin I within 24?h after ED arrival. Measurements of left ventricular ejection fraction and wall motion abnormalities were performed to evaluate cardiac function. If a patient had CO-induced cardiomyopathy, we measured cardiac function at the time of patient admission, day 1, day 2, and once within seven days of hospitalization. Results: The incidence of cardiomyopathy was as high as 74.4% (32 of 43 patients) in CO-poisoned patients with myocardial injury based on initial ED results. Echocardiographic patterns included non-cardiomyopathy (25.6%), global dysfunction (51.2%), and Takotsubo-like cardiomyopathy (23.2%). Patients in the global dysfunction group had significantly more normalized cardiac dysfunction within 72?h than did those in the Takotsubo-like cardiomyopathy group (81.8% vs. 22.2%, p?=?0.001). Discussion and conclusion: Patients with CO poisoning and myocardial injury experienced cardiomyopathy, including reversible global dysfunction and a Takotsubo-like pattern. Investigation of cardiomyopathy needs to be considered in patients with CO poisoning and myocardial injury. 相似文献
999.
1000.
Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene 总被引:1,自引:0,他引:1 下载免费PDF全文
This work identifies an ISCR1-related bla(CTX-M-14) gene, which has never been reported before, from a clinical isolate of Escherichia coli. The bla(CTX-M-14) gene was preceded by an ISCR1 element that was followed by a class 1 integron containing three different insert gene cassettes, i.e., dfrA12, orfF, and aadA2. 相似文献