全文获取类型
收费全文 | 2530篇 |
免费 | 150篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 82篇 |
妇产科学 | 66篇 |
基础医学 | 311篇 |
口腔科学 | 29篇 |
临床医学 | 286篇 |
内科学 | 512篇 |
皮肤病学 | 86篇 |
神经病学 | 152篇 |
特种医学 | 60篇 |
外国民族医学 | 3篇 |
外科学 | 291篇 |
综合类 | 36篇 |
预防医学 | 66篇 |
眼科学 | 25篇 |
药学 | 126篇 |
中国医学 | 12篇 |
肿瘤学 | 525篇 |
出版年
2023年 | 9篇 |
2022年 | 12篇 |
2021年 | 46篇 |
2020年 | 29篇 |
2019年 | 49篇 |
2018年 | 58篇 |
2017年 | 38篇 |
2016年 | 27篇 |
2015年 | 47篇 |
2014年 | 80篇 |
2013年 | 103篇 |
2012年 | 197篇 |
2011年 | 163篇 |
2010年 | 115篇 |
2009年 | 92篇 |
2008年 | 164篇 |
2007年 | 164篇 |
2006年 | 150篇 |
2005年 | 147篇 |
2004年 | 165篇 |
2003年 | 128篇 |
2002年 | 124篇 |
2001年 | 89篇 |
2000年 | 76篇 |
1999年 | 75篇 |
1998年 | 13篇 |
1997年 | 27篇 |
1996年 | 11篇 |
1995年 | 12篇 |
1994年 | 15篇 |
1993年 | 13篇 |
1992年 | 33篇 |
1991年 | 36篇 |
1990年 | 26篇 |
1989年 | 15篇 |
1988年 | 24篇 |
1987年 | 12篇 |
1986年 | 23篇 |
1985年 | 11篇 |
1984年 | 12篇 |
1983年 | 16篇 |
1982年 | 5篇 |
1979年 | 7篇 |
1977年 | 3篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1967年 | 4篇 |
排序方式: 共有2691条查询结果,搜索用时 0 毫秒
61.
Mönkkönen KS Aflatoonian R Lee KF Yeung WS Tsao SW Laitinen JT Tuckerman EM Li TC Fazeli A 《Human reproduction (Oxford, England)》2007,22(5):1224-1230
BACKGROUND: Heterotrimeric G proteins take part in membrane-mediated cell signalling and have a role in hormonal regulation. This study clarifies the expression and localization of the G protein subunit G alpha(i2) in the human endometrium and Fallopian tube and changes in G alpha(i2) expression in human endometrium during the menstrual cycle. METHODS: The expression of G alpha(i2) was identified by Polymerase chain reaction (PCR), and localization confirmed by immunostaining. Cyclic changes in G alpha(i2) expression during the menstrual cycle were evaluated by quantitative real-time PCR. RESULTS: We found G alpha(i2) to be expressed in human endometrium, Fallopian tube tissue and in primary cultures of Fallopian tube epithelial cells. Our studies revealed enriched localization of G alpha(i2) in Fallopian tube cilia and in endometrial glands. We showed that G alpha(i2) expression in human endometrium changes significantly during the menstrual cycle, with a higher level in the secretory versus proliferative and menstrual phases (P < 0.05). CONCLUSIONS: G alpha(i2) is specifically localized in human Fallopian tube epithelial cells, particularly in the cilia, and is likely to have a cilia-specific role in reproduction. Significantly variable expression of G alpha(i2) during the menstrual cycle suggests G alpha(i2) might be under hormonal regulation in the female reproductive tract in vivo. 相似文献
62.
Chen GW Shih SR Hsiao MR Chang SC Lin SH Sun CF Tsao KC 《Journal of clinical microbiology》2007,45(5):1515-1522
An influenza B outbreak occurred in Taiwan in 2004 and 2005, during which both Victoria (Vic) and Yamagata (Ya) lineages cocirculated. This study examined 36 influenza B viral genomes isolated during the outbreak to reveal their reassortment patterns. According to the isolate groupings in phylogenetic analysis, we were able to categorize those 36 isolates as being of either the Victoria or Yamagata lineage for all eight influenza B virus genomic segments, except for the NS gene, in which clades A and B existed. Based on these groupings, three genome patterns clearly emerged, namely, pattern I (Vic+Vic+Ya+Vic+Ya+Ya+Ya+A, from segments 1 to 8), pattern II (Ya+Ya+Ya+Ya+Ya+Ya+Ya+B), and pattern III (Ya+Ya+Ya+Ya+Ya+Ya+Ya+A). According to the timeline of those isolates under investigation, it appears that pattern I and II viruses could have generated pattern III via reassortment of the NS gene. On the other hand, a genomewide comparison of all six pattern III Taiwanese viruses with 37 international influenza B viral genomes showed that two international strains, B/Oslo/71/04 and B/England/23/04, were consistently clustered with the pattern III viruses isolated in Taiwan in 2004 and 2005, suggesting that Taiwanese pattern III viruses might also have been imported due to their matching genomic composition. 相似文献
63.
The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas 总被引:7,自引:0,他引:7
64.
65.
Tsao PN Chan FT Wei SC Hsieh WS Chou HC Su YN Chen CY Hsu WM Hsieh FJ Hsu SM 《Critical care medicine》2007,35(8):1955-1960
OBJECTIVE: To determine the putative role in the modulation of inflammation of a soluble form of Flt-1 (sFlt), a potent vascular endothelial growth factor antagonist, in experimental endotoxemia and sepsis. DESIGN: Randomized prospective experimental study. SETTING: University medical laboratory. SUBJECTS: Male C56BL/6 strain mice. INTERVENTIONS: We investigated the expression patterns and the effects of vascular endothelial growth factor and soluble Flt-1 in experimental endotoxic shock and sepsis. The possible anti-inflammatory mechanism of soluble Flt-1 was also evaluated. MEASUREMENTS AND MAIN RESULTS: Both vascular endothelial growth factor and sFlt-1 were rapidly released from macrophages activated in vitro by lipopolysaccharide and in the plasma of endotoxemic mice. Administration of vascular endothelial growth factor enhanced proinflammatory cytokine production and mediated a dramatic increase in mortality in endotoxemic mice. Treatment with sFlt-1 attenuated inflammatory responses, inhibited recruitment of inflammatory cells into the peritoneal cavity, and improved survival in a lethal endotoxemia and cecal ligation and puncture-induced sepsis model, even when administered as late as 24 hrs after the onset of sepsis. CONCLUSIONS: These findings support a critical protective role of sFlt-1 in endotoxic shock and sepsis. sFlt-1 may therefore have utility as an adjunctive agent for the treatment of sepsis syndrome. 相似文献
66.
67.
Seshadri Balaji Ankana Daga David J. Bradley Susan P. Etheridge Ian H. Law Anjan S. Batra Shubayan Sanatani Anoop K. Singh Kelly K. Gajewski Sabrina Tsao Harinder R. Singh Svjetlana Tisma-Dupanovic Shigeru Tateno Motoki Takamuro Hiromichi Nakajima Jolien W. Roos-Hesselink Maully Shah 《The Journal of thoracic and cardiovascular surgery》2014
68.
69.
Yu-Cing Juho Seng-Tang Wu En Meng Chih-Wei Tsao Tai-Lung Cha Dah-Shyong Yu Guang-Huan Sun Cheng-Ping Ma Sun-Yran Chang Shou-Hung Tang 《Urological Science》2014,25(4):137-138
For patients who are suffering from neurogenic lower urinary tract dysfunction, intermittent urinary catheterization is an efficient way to empty the bladder.1 However, the method may result in various complications. Herein we present a rare complication of extraperitoneal abscess owing to intermittent urinary catheterization in a 62-year-old male who had cervical spine injury and was treated with intermittent urethral catheterization for neurogenic lower urinary tract dysfunction. Treatment and a literature review are also described. 相似文献
70.
Bryan E. Tsao MD Mark A. Ferrante MD Asa J. Wilbourn MD Robert W. Shields JR MD 《Muscle & nerve》2014,49(5):724-727
Introduction: We report the electrodiagnostic (EDX) features of 32 patients with surgically verified true neurogenic thoracic outlet syndrome (TN‐TOS). Methods: Retrospective record review. Results: We found uniform EDX evidence of a chronic axon loss process that affected the lower portion of the brachial plexus and disproportionately involved the T1 more than the C8 sensory and motor fibers. Because of this relationship, the medial antebrachial cutaneous sensory nerve (T1) and median motor (T1 > C8) study combination was abnormal in 89%, whereas response combinations that primarily assessed the C8 fibers were less frequently affected. Conclusions: The characteristic EDX features of TN‐TOS are T1 > C8 nerve fiber involvement. A comprehensive EDX examination of the lower plexus with contralateral comparison studies is imperative to diagnose this disorder accurately. Muscle Nerve 49 : 724–727, 2014 相似文献