全文获取类型
收费全文 | 1361篇 |
免费 | 146篇 |
国内免费 | 52篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 102篇 |
妇产科学 | 19篇 |
基础医学 | 110篇 |
口腔科学 | 49篇 |
临床医学 | 110篇 |
内科学 | 407篇 |
皮肤病学 | 29篇 |
神经病学 | 21篇 |
特种医学 | 192篇 |
外科学 | 143篇 |
综合类 | 97篇 |
预防医学 | 76篇 |
眼科学 | 9篇 |
药学 | 69篇 |
中国医学 | 3篇 |
肿瘤学 | 114篇 |
出版年
2024年 | 3篇 |
2023年 | 17篇 |
2022年 | 14篇 |
2021年 | 29篇 |
2020年 | 22篇 |
2019年 | 15篇 |
2018年 | 23篇 |
2017年 | 48篇 |
2016年 | 44篇 |
2015年 | 34篇 |
2014年 | 74篇 |
2013年 | 79篇 |
2012年 | 39篇 |
2011年 | 47篇 |
2010年 | 73篇 |
2009年 | 77篇 |
2008年 | 44篇 |
2007年 | 83篇 |
2006年 | 62篇 |
2005年 | 40篇 |
2004年 | 30篇 |
2003年 | 15篇 |
2002年 | 14篇 |
2001年 | 34篇 |
2000年 | 18篇 |
1999年 | 17篇 |
1998年 | 78篇 |
1997年 | 64篇 |
1996年 | 59篇 |
1995年 | 50篇 |
1994年 | 45篇 |
1993年 | 42篇 |
1992年 | 14篇 |
1991年 | 7篇 |
1990年 | 17篇 |
1989年 | 22篇 |
1988年 | 27篇 |
1987年 | 15篇 |
1986年 | 19篇 |
1985年 | 20篇 |
1984年 | 9篇 |
1983年 | 12篇 |
1982年 | 10篇 |
1981年 | 4篇 |
1980年 | 8篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 12篇 |
1975年 | 9篇 |
排序方式: 共有1559条查询结果,搜索用时 16 毫秒
91.
Shinichi Hasegawa MD Takaki Yoshikawa MD PhD Yasushi Rino MD Takashi Oshima MD PhD Toru Aoyama MD Tsutomu Hayashi MD Tsutomu Sato MD Norio Yukawa MD Yoichi Kameda MD PhD Takeshi Sasaki MD PhD Hidetaka Ono MD PhD Kazuhito Tsuchida MD Haruhiko Cho MD Chikara Kunisaki MD PhD Munetaka Masuda MD PhD Akira Tsuburaya MD 《Annals of surgical oncology》2013,20(13):4252-4259
Objective
The purpose of this study was to clarify the priority of nodal dissection in Siewert types II and III adenocarcinoma of the esophagogastric junction (AEG).Methods
The priority of nodal dissection was evaluated based on the therapeutic value index calculated by multiplying of the frequency of metastasis to each station and the 5-year survival rate of patients with metastasis to that station.Results
A total of 176 patients (95 type II and 81 type III) were examined. Among the lymph nodes that had a metastatic incidence exceeding 10 %, the stations showing the first to fourth highest index were the paracardial and lesser curvature nodes (Nos. 1, 2, and 3) and the node at the root of the left gastric artery (No. 7) in the total cohort, as well as in each type. The next station was the lower thoracic paraesophageal lymph node (No. 110), followed by the nodes along the proximal splenic artery (No. 11p) in type II, whereas it was the nodes along the proximal splenic artery (No. 11p) followed by the para-aortic nodes (No. 16a2), the nodes at the celiac artery (No. 9), and the nodes around the splenic hilum (No. 10) in type III.Conclusions
These results suggest that the highest priority nodal stations to be dissected were the paracardial and lesser curvature nodes (Nos. 1, 2, and 3) and the nodes at the root of the left gastric artery (No. 7), regardless of the Siewert subtype, but the subsequent priority was different depending on the subtype. 相似文献92.
Kunisaki C Makino H Kosaka T Oshima T Fujii S Takagawa R Kimura J Ono HA Akiyama H Taguri M Morita S Endo I 《Surgical endoscopy》2012,26(3):804-810
Background
The aim of this study was to clarify the technical feasibility and oncological efficacy of laparoscopy-assisted gastrectomy (LAG) for gastric cancer compared with open gastrectomy (OG).Methods
Between April 2002 and March 2008, a series of 623 patients with gastric cancer underwent R0 gastrectomy (314 LAG patients and 309 OG patients). Age, gender, lymph node dissection, and pathological stage were matched by propensity scoring, and 212 patients (106 LAG and 106 OG) were selected for analysis after the exclusion of 40 patients who had proximal gastrectomy. Intraoperative factors, postoperative morbidity, long-term quality of life (QOL), and survival were evaluated. Moreover, these outcomes were also compared between the laparoscopy-assisted total gastrectomy (LATG) and the open total gastrectomy (OTG).Results
There was no significant difference in preoperative characteristics between the two patient groups. Regarding intraoperative characteristics, blood loss was significantly lower in the LAG group (143?ml) than in the OG group (288?ml), while operation time was significantly longer in the LAG group (273?min) than the OG group (231?min). The degree of lymph node dissection and number of retrieved lymph nodes did not differ between the two groups. There were no significant differences in postoperative courses or overall and disease-specific survival (89.8% vs. 83.6%, P?=?0.0886; 100% vs. 95.2%, P?=?0.1073) except time to first flatus and time to use of nonsteroidal anti-inflammatory derivatives between the two groups. Significantly fewer patients felt wound pain in the LAG group 1?year after surgery. Analyses between the LATG and OTG groups showed similar results.Conclusions
LAG for gastric cancer may be both feasible and safe. However, it will be necessary to conduct a well-designed randomized controlled trial comparing short-term and long-term outcomes between LAG and OG in a larger number of patients. 相似文献93.
Takagawa R Fujii S Ohta M Nagano Y Kunisaki C Yamagishi S Osada S Ichikawa Y Shimada H 《Annals of surgical oncology》2008,15(12):3433-3439
Background We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colorectal
cancer (CRC).
Patients and Methods The study group comprised 638 patients. The optimal cutoff value for the preoperative serum CEA level was determined. Predictive
factors of recurrence were evaluated using multivariate analyses. The relapse-free time was investigated according to the
CEA level.
Results All patients underwent potentially curative resection for CRC without distant metastasis, classified as stage I, II, or III.
The optimal cutoff value for preoperative serum CEA level was 10 ng/ml. Elevated preoperative serum CEA level was observed
in 92 patients. Multivariate analysis identified tumor–node–metastasis (TNM) stage and preoperative serum CEA level as independent
predictive factors of recurrence. The relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml significantly differed
in patients with stage II and III. However, there was no significant difference in relapse-free survival between CEA levels
>10 ng/ml and <10 ng/ml in patients with stage I.
Conclusion Preoperative serum CEA is a reliable predictive factor of recurrence after curative surgery in CRC patients and a useful indicator
of the optimal treatment after resection, particularly for cases classified as stage II or stage III. 相似文献
94.
95.
96.
97.
98.
Background
Despite extensive research, the five-year survival rate of oral squamous cell carcinoma (OSCC) patients has not improved. Effective treatment of OSCC requires the identification of molecular targets and signaling pathways to design appropriate therapeutic strategies. Several genes from the mTOR signaling pathway are known to be dysregulated in a wide spectrum of cancers. However, not much is known about the involvement of this pathway in tumorigenesis of OSCC. We therefore investigated the role of the tumor suppressor genes, TSC1 and TSC2, and other members of this pathway in tumorigenesis of OSCC. 相似文献99.
100.
Carriage of Haemophilus influenzae and Streptococcus pneumoniae in healthy Chinese and Vietnamese children in Hong Kong 总被引:1,自引:0,他引:1
RYT Sung JM Ling SM Fung SJ Oppenheimer DW Crook JTF Lau AFB Cheng 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(11):1262-1267
Nasopharyngeal carriage of Haemophilus influenzae and Streptococcus pneumoniae was studied in 621 healthy Chinese children and 300 healthy Vietnamese children aged from 2 months to 5 years in Hong Kong. The carriage rate of H, influenzae type b in Vietnamese children was 1.3% (CI 0.04-2.63%); it was zero in Chinese. The carriage rate of non-typable H. influenzae was 5.8% (CI 1.4-7.6%) in Chinese and 65.4% (CI 58.9-69.8%) in Vietnamese. The carriage rates of S. pneumoniae were 10.8% (CI 8.3-13.2%) and 55.7% (CI 50.1-61.3%) in Chinese and Vietnamese children, respectively. Univariate and multivariate logistic regression analyses were performed to search for factors associated with differences in carriage rates of both H. influenzae and S. pneumoniae between Chinese and Vietnamese children. Although older age, smaller living area and parental smoking were associated with higher carriage rates, these could not explain the remarkably low carriage rates of both bacteria in Chinese children. 相似文献