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61.
Seoung‐Jin Hong Hyeonjong Lee Janghyun Paek Ahran Pae Hyeong‐Seob Kim Kung‐Rock Kwon Kwantae Noh 《Journal of prosthodontics》2019,28(5):592-595
The conventional method for impressions of flabby tissue uses modified trays and highly flowable materials, but mucostatic impressions are difficult to achieve due to the viscous and the elastic natures of impression materials. In this report, a technique is presented in which conventional impression and intraoral scanning for a fully edentulous patient with flabby tissue are combined. The definitive impression was obtained by applying appropriate pressure to each tissue area, and the denture can be maintained passively and stable at rest and during function. 相似文献
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Kuo LJ Chiou JF Tai CJ Chang CC Kung CH Lin SE Hung CS Wang W Tam KW Lee HC Liang HH Chang YJ Wei PL 《International journal of colorectal disease》2012,27(5):613-621
Background
Pathologic complete response has been proven to have oncological benefits for locally advanced rectal cancer treated with chemoradiation therapy. The aims of this study are to analyze and determine the factors to predict pathologic complete response for patients treated with preoperative neoadjuvant therapy.Methods
Patients with biopsy-proven, locally advanced rectal cancer were treated neoadjuvantly followed by radical surgical resection. Tumors were re-assessed after completing chemoradiation, including pelvic magnetic resonance images, colonoscopic examination, and re-biopsy. The results of examination were compared with the final pathologic status.Results
A retrospective chart review of 166 patients was conducted. Twenty-five patients (15.1%) had pathologic complete response after chemoradiation. The 5-year overall survival rates were better in the complete response group than the residual tumor group (91.1% vs. 70.8%; P?=?0.047), and there were also significant differences in the 5-year disease-free survival rates between these two groups (91.1% vs. 70.2%; P?=?0.027). The prediction rates for pathologic complete response by re-biopsy, magnetic resonance images, and colonoscopy were 21.4%, 33.3%, and 53.8%, respectively. In addition, when we further combine the results of colonoscopic findings and re-biopsy, the prediction rate for pathologic complete response reached 77.8% (P?=?0.009).Conclusions
Combining the results of the re-biopsy and post-treatment colonoscopic findings, we can achieve a good prediction rate for pathologic complete response. Post-treatment magnetic resonance images are not useful tools in predicting tumor clearance following chemoradiation. 相似文献65.
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A. M. Aiken J. B. Haddow N. R. A. Symons S. Kaptanis A. C. Katz-Summercorn D. Debnath H. Dent S. Tayeh V. Kung S. Clark J. Gahir S. Dindyal S. Farag A. Lazaridis C. P. Bretherton S. Williams A. Currie H. West J. Davies S. Arora A. Kheraj B. M. Stubbs N. Yassin S. Mallappa G. Garrett S. Hislop A. Bhangu Y. Abbey I. Al-Shoek U. Ahmad G. Sharp A. Memarzadeh A. Patel F. Ali H. Kaderbhai C. H. Knowles 《Hernia》2013,17(5):657-664
Purpose
Evidence regarding whether or not antibiotic prophylaxis is beneficial in preventing post-operative surgical site infection in adult inguinal hernia repair is conflicting. A recent Cochrane review based on 17 randomised trials did not reach a conclusion on this subject. This study aimed to describe the current practice and determine whether clinical equipoise is prevalent.Methods
Surgeons in training were recruited to administer the Survey of Hernia Antibiotic Prophylaxis usE survey to consultant-level general surgeons in London and the south-east of England on their practices and beliefs regarding antibiotic prophylaxis in adult elective inguinal hernia repair. Local prophylaxis guidelines for the participating hospital sites were also determined.Results
The study was conducted at 34 different sites and received completed surveys from 229 out of a possible 245 surgeons, a 93 % response rate. Overall, a large majority of hospital guidelines (22/28) and surgeons’ personal beliefs (192/229, 84 %) supported the use of single-dose pre-operative intravenous antibiotic prophylaxis in inguinal hernia repair, although there was considerable variation in the regimens in use. The most widely used regimen was intravenous co-amoxiclav (1.2 g). Less than half of surgeons were adherent to their own hospital antibiotic guidelines for this procedure, although many incorrectly believed that they were following these.Conclusion
In the south-east of England, there is a strong majority of surgical opinion in favour of the use of antibiotic prophylaxis in this procedure. It is therefore likely to be extremely difficult to conduct further randomised studies in the UK to support or refute the effectiveness of prophylaxis in this commonly performed procedure. 相似文献67.
An enzymatic approach to configurationally rare trans‐androsteronyl‐α‐glucoside and Its potential anticancer application
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Feng‐Pai Chou Chia‐Tse Tsai Ya‐Sheng Chiou Yi‐Ju Chen Meng‐Erh Li Ting‐Wei Guo Jason WenJay Lyu Sheng‐Hao Chou Tung‐Kung Wu 《Chemical biology & drug design》2017,89(1):61-66
Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl‐α‐glucosides. Investigation of trans‐androsteronyl‐α‐glucoside on tamoxifen‐treated MCF‐7 breast cancer cells shows dose‐dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl‐α‐glucosides with useful biological activities. 相似文献
68.
No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children
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