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Sendhil M Kumaran Ishwara P Bhat J Madhukara Pritilata Rout J Elizabeth 《Indian journal of dermatology》2015,60(1):51-54
Background:
As the world moves toward elimination of leprosy, persistence of infective cases in endemic pockets remains a significant problem. The use of clinical criteria to decide the paucibacillary (PB) versus multibacillary (MB) regimens has greatly simplified therapy at the field setting. However, a small but significant risk of under-treatment of so-called “PB” cases which actually have significant bacillary load exists. This study was undertaken to assess this risk and compare two methods of assessment of bacillary load, namely bacillary index on slit skin smear (BIS) versus bacillary index of granuloma (BIG).Aims:
To compare BIS with BIG on skin biopsy in consecutive untreated cases of leprosy.Materials and Methods:
This prospective study was conducted over a period of 12 months, wherein new untreated patients with leprosy were consecutively recruited. After a thorough clinical examination, each patient underwent slit skin smear (SSS) where the BIS was calculated. The same patient also underwent a skin biopsy from a clinical lesion where, the BIG was calculated. SSS and skin biopsy for BIS and BIG respectively were repeated for all patients at the end of therapy for comparison. All patients received therapy according to World Health Organization-Multidrug Therapy Guidelines.Results:
The BIG was positive in all cases where the BIS was positive. Significantly, BIG was positive in three cases of borderline tuberculoid leprosy with <5 lesions who received PB regimen, whereas the BIS was negative in all three cases.Conclusion:
This study suggests that BIG may be a better indicator of the true bacillary load in leprosy as compared to BIS. Its role in management is significant, at least in tertiary care centers to prevent “under-treatment” of so called PB cases, which may actually warrant MB regimens. 相似文献76.
Biomimetic and bioactive biomaterials are desirable as tissue engineering scaffolds by virtue of their capability to mimic natural environments of the extracellular matrix. Biomimeticity has been achieved by the incorporation of synthetic short peptide sequences into suitable materials either by surface modification or by bulk incorporation. Research in this area has identified several novel synthetic peptide segments, some of them with cell-specific interactions, which may serve as potential candidates for use in explicit tissue applications. This review focuses on the developments and prospective directions of incorporating short synthetic peptide sequences onto scaffolds for tissue engineering, with emphasis on the chemistry of peptide immobilization and subsequent cell responses toward modified scaffolds. The article provides a decision-tree-type flow chart indicating the most probable cellular events on a given peptide-modified scaffold along with the consolidated list of synthetic peptide sequences, supports as well as cell types used in various tissue engineering studies, and aims to serve as a quick reference guide to peptide chemists and material scientists interested in the field. 相似文献
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Ashutosh K. Tewari Abhishek Srivastava Kumaran Mudaliar Gerald Y. Tan Sonal Grover Youssef El Douaihy David Peters Robert Leung Rajiv Yadav Majnu John James Wysock E. Daracott Vaughan Sara Muir Mahul B. Amin Mark Rubin Jiangling Tu Mohammed Akthar Maria Shevchuk 《BJU international》2010,106(9):1364-1373
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Kyung Park Scott A Tomlins Kumaran M Mudaliar Ya-Lin Chiu Raquel Esgueva Rohit Mehra Khalid Suleman Sooryanarayana Varambally John C Brenner Theresa MacDonald Abhishek Srivastava Ashutosh K Tewari Ubaradka Sathyanarayana Dea Nagy Gary Pestano Lakshmi P Kunju Francesca Demichelis Arul M Chinnaiyan Mark A Rubin 《Neoplasia (New York, N.Y.)》2010,12(7):590-598
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