The effect of tubular penetration of root canal sealers on dye microleakage

An in vitro study of a possible correlation between penetration of dentinal tubules by four root canal sealers and microleakage of external fluids into the canal was done using a dye leakage method and scanning electron microscopy. The root canals of 45 teeth were instrumented and the smear layer removed prior to obturation of root canals with gutta-percha and one of four sealers: Diaket, Endomethasone, CRCS or Ketac-Endo. The extent of leakage was scored after immersion in India ink for 72 h. The same specimens were also used for scanning electron microscopic evaluation. There was a statistical difference in leakage patterns between the groups ( P <0.05). Diaket had lower microleakage scores than the other sealers ( P <0.05). When the scores for penetration of sealers into the tubules were analysed, Ketac-Endo demonstrated the least penetration ( P <0.01). There appeared to be a converse relation between tubular penetration and dye leakage, but the correlation was not statistically significant ( P <0.05).     

SLE患者生长激素和泌乳素对促甲状腺激素释放激素的反应及与下丘 -垂体 -肾上腺皮质轴间的相互作用

为了探讨垂体分泌泌乳素（PRL）和生长激素（GH）以及下丘－垂体－肾上腺皮质轴活动。采用RIA法测定未治疗SLE活动期和正常对照组、SLE静止期血清PRL、GH、促甲状腺激素释放激素（TSH），促肾上腺皮质激素（ACTH）和皮质醇水平。结果显示SLE患者活动期血清PRL和GH水平与静止期患者及年龄性别配对的正常对照组比较显著升高，而血清ACTH和皮质醇水平显著下降；SLE患者活动期（PRL＋GH）／皮质醇比值与dsDNA抗体滴度正相关。提示SLE活动期患者存在垂体GH和PRL的分泌与下丘－垂体－肾上腺皮质轴活动失衡。     

复杂粉碎性髋臼骨折关节面手术重建方法的临床研究

目的 探讨复杂粉碎性髋臼骨折的手术修复方法.方法 髋臼复杂粉碎性骨折患者148例,其中关节脱位状态下手术组(对照组)46例,关节复位状态下手术组(观察组)102例,比较两组手术时间、出血量、输血量、骨折复位质量、术后并发症.结果 观察组手术时间短于对照组,术中出血量及输血量少于对照组、术后不良反应发生率低于对照组,差异...     

中西医结合治疗胆石症

目的：探讨体外震波碎石（ESWL）结合消石利胆合剂在治疗胆石症中的疗效。方法：对387例胆石症患者,随机分组对照,治疗组在ESWL基础上加消石利胆合剂,每日一剂;对照组在ESWL基础上加复方胆通及熊去氧胆酸,疗程2周。结果：治疗组：治愈47例、显效123例、有效45例、无效16例、显效率73.59%(170/231）,总有效率93.07%（215／231）。对照组：治愈15例、显效37例、有效59例、无效45例,显效率33.34%（52／156）,总有效率71.16%(111/156)。两组疗效有显著性差异,治疗组优于对照组。结论：ESWL加中药专方专药在胆石溶石排石治疗中具有一定优势,值得进一步研究及推广。     

Identification and characterization of a high-affinity granulocyte- macrophage colony-stimulating factor receptor on primary rat oligodendrocytes

We previously showed the presence of receptors for granulocyte- macrophage colony-stimulating factor (GM-CSF) on tumor tissues and tumor cell lines that are derived from the neural crest. To determine whether normal neural cells express functional GM-CSF receptors, we isolated and analyzed primary rat brain cells, including microglia, astrocytes, and oligodendrocytes. Scatchard analysis of equilibrium binding of 125I-GM-CSF to primary rat oligodendrocytes showed an average of 1,110 GM-CSF binding sites per cell, with a kd of 20 pmol/L. In six separate experiments, no specific binding was detectable on the astrocyte population. Microglia were used in competitive binding experiments with oligodendrocytes, and addition of microglia did not increase the specific binding of labeled ligand to oligodendrocytes. In dose-response assays, we measured 3H-thymidine uptake in rat oligodendrocytes, microglia and control murine 32D cells stimulated with various concentrations of GM-CSF. Over concentration ranges of 0.025 to 1000 pmol/L, cell proliferation and peak 3H-thymidine incorporation was observed at approximately 30 pmol/L for both the control cells and the oligodendrocytes. However, the microglial cells did not proliferate in response to GM-CSF. These data indicate the presence of a functional receptor for GM-CSF on primary rat oligodendrocytes, and suggest that hematopoietic growth factors such as GM-CSF may play a role in nerve cell development, function, or response to injury.     

Coexistence of diffuse plane normolipaemic xanthoma and amyloidosis in a patient with monoclonal gammopathy

Diffuse plane normolipaemic xanthomatosis (DPNX) is a well-defined clinicopathological entity that characteristically presents with yellow–orange plaques in the periorbital areas, the neck, the upper trunk and the flexural folds. DPNX has been reported in association with lymphoproliferative disorders and, occasionally, with miscellaneous, probably coincidental disorders. A case of DPNX in a patient with an IgGλ monoclonal gammopathy and systemic amyloidosis is reported. Clinical and histopathological findings revealed typical features of DPNX and amyloidosis coexisting in the cutaneous lesions. To our knowledge this is the first reported case showing coexistence of xanthoma and amyloidosis in cutaneous lesions in a patient with a monoclonal gammopathy.