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排序方式: 共有144条查询结果,搜索用时 31 毫秒
51.
52.
NB Pitts KR Ekstrand The ICDAS Foundation 《Community dentistry and oral epidemiology》2013,41(1):e41-e52
53.
54.
55.
Andrea Wilcken Flavia Miiro-Nakayima Ramadhan NB Hizaamu Thomas Keil Dorothy Balaba-Byansi 《BMC public health》2010,10(1):209
Background
Medical male circumcision is now part of a comprehensive approach to HIV prevention. It has been shown that awareness of the protective effect of male circumcision leads to high acceptability towards the introduction of medical male circumcision services within countries. The objective of this survey was to identify factors determining awareness of male circumcision for HIV prevention. 相似文献56.
K. P. Ward N. B. Kuemmerle R. J. Krieg P. Saborio E. P. Norkus J. C. M. Chan 《Clinical and experimental nephrology》2000,4(3):187-192
Background. We have previously shown that α-tocopherol prevents oxidative stress in experimental IgA nephropathy (IgAN) when administered
before or concurrent with the induction of IgAN. We now seek to determine whether α-tocopherol can ameliorate the disease
after IgAN is established.
Methods. Using the classic IgAN model, 25 male Lewis rats were sorted into five groups of five animals each: 4-week control, 4-week
bovine gamma globulin (BGG) treatment, 6-week control, 6-week BGG treatment, and 6-week BGG treatment with α-tocopherol administration
started after 4 weeks. Serum α-tocopherol concentrations, kidney and plasma malondialdehyde concentrations, and kidney transforming
growth factor beta-1 (TGFβ1) mRNA were analyzed.
Results.α-Tocopherol modulated IgAN after the disease was established in the 4-week BGG model, as indicated by the reduction in tissue
oxidative stress, dampening of fibrogenic cytokine (TGFβ1), and abatement of proteinuria in α-tocopherol-treated animals compared
with untreated rats.
Conclusions. These results substantiate the anti-oxidant role of α-tocopherol in diminishing the indices associated with progression of
experimental IgAN. The ability of α-tocopherol to reduce the progression of injury after establishment of the disease reflects
the clinical situation, and thus holds promise for human therapy.
Received: October 13, 1999 / Accepted: February 3, 2000 相似文献
57.
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. 总被引:24,自引:0,他引:24
R J Ferrante O A Andreassen B G Jenkins A Dedeoglu S Kuemmerle J K Kubilus R Kaddurah-Daouk S M Hersch M F Beal 《The Journal of neuroscience》2000,20(12):4389-4397
Huntington's disease (HD) is a progressive neurodegenerative illness for which there is no effective therapy. We examined whether creatine, which may exert neuroprotective effects by increasing phosphocreatine levels or by stabilizing the mitochondrial permeability transition, has beneficial effects in a transgenic mouse model of HD (line 6/2). Dietary creatine supplementation significantly improved survival, slowed the development of brain atrophy, and delayed atrophy of striatal neurons and the formation of huntingtin-positive aggregates in R6/2 mice. Body weight and motor performance on the rotarod test were significantly improved in creatine-supplemented R6/2 mice, whereas the onset of diabetes was markedly delayed. Nuclear magnetic resonance spectroscopy showed that creatine supplementation significantly increased brain creatine concentrations and delayed decreases in N-acetylaspartate concentrations. These results support a role of metabolic dysfunction in a transgenic mouse model of HD and suggest a novel therapeutic strategy to slow the pathological process. 相似文献
58.
Detection of intraventricular thrombi by computed tomography 总被引:2,自引:0,他引:2
Godwin JD; Herfkens RJ; Skioldebrand CG; Brundage BH; Schiller NB; Lipton MJ 《Radiology》1981,138(3):717
59.
Biliary obstruction after cholecystectomy: diagnosis with quantitative cholescintigraphy 总被引:3,自引:0,他引:3
Kloiber R; AuCoin R; Hershfield NB; Logan K; Molnar CP; Blair KM; Shaffer EA 《Radiology》1988,169(3):643-647
Fifty patients with recurrent post-cholecystectomy pain underwent hepatobiliary scintigraphy. Time-activity curves were generated from regions of interest over the liver, bile duct, duodenum, and bowel. Patients were divided into obstructed and unobstructed groups with endoscopic retrograde cholangiopancreatography criteria. Measurements from the liver, duodenum, and bowel curves contributed little to the analysis. The washout phase of the bile duct curve showed intermittent emptying in both obstructed and unobstructed groups. Less than one-third of peak activity remained in both groups at 90 minutes. Retention fell more rapidly in the later portion of the sequence in patients with obstruction. Quantification was essential, since differences were subtle and could not be appreciated visually. In the absence of hepatocellular disease, the most reliable criterion was the time at which maximal bile duct activity occurred. A cutoff level of 29 minutes or more was used in the diagnosis of obstruction. A sensitivity of 93% with an adequate specificity of 64% and an overall accuracy of 80% was achieved in the prediction of obstruction. 相似文献
60.
Barium enema examination following biopsy of the rectum or colon 总被引:3,自引:1,他引:2