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991.
992.
Mariko Yamashita Tetsuro Tominaga Takashi Nonaka Akiko Fukda Masaaki Moriyama Syosaburo Oyama Kenji Tanaka Kiyoaki Hamada Masato Araki Yorihisa Sumida Hiroaki Takeshita Makoto Hisanaga Hidetoshi Fukuoka Hideo Wada Kazuo Tou Terumitsu Sawai Takeshi Nagayasu 《Asian journal of endoscopic surgery》2021,14(3):432-442
993.
994.
995.
Iikubo Masahiro Kagawa Toyohiro Fujisawa Junya Kumasaka Akira Nishioka Takashi Kojima Ikuho Sakamoto Maya Kobayashi Kaoru Yuasa Kenji 《Oral Radiology》2020,36(4):344-348
Oral Radiology - To ascertain the effects of exposure parameters (tube current and tube voltage) and the gutta-percha cone (GPC) size on root fracture-like artifacts obtained with cone-beam... 相似文献
996.
Eisuke Suganuma Hideaki Sakata Nodoka Adachi Satoshi Asanuma Mihoko Furuichi Yoji Uejima Satoshi Sato Tomoya Abe Daigo Matsumoto Ryohei Takahashi Sachi Yamamoto Yutaka Kawano Takashi Arai Tsutomu Oh-ishi 《Journal of infection and chemotherapy》2021,27(2):185-191
ObjectivesValganciclovir (VGCV) has been shown to improve sensorineural hearing loss (SNHL) and neurological outcomes in patients with neonatal symptomatic congenital cytomegalovirus (cCMV) infection. However, reports on the pharmacokinetics, efficacy and safety of oral VGCV are limited. The aim of this study is to evaluate the pharmacokinetics of VGCV for use in the treatment of cCMV.MethodsThis was a single-center, retrospective observational study conducted at Saitama Children's Medical Center in Japan between 2012 and 2017. CMV DNA copy number, maximum plasma VGCV concentration (Cmax), and adverse events (ADEs) during treatment were evaluated.ResultsA total of 26 patients with cCMV who received VGCV were included in this study. The median age at VGCV initiation was 9.5 months (range 0–46). Twenty-one patients (81%) had SNHL at baseline. Of these, five patients (19%) presented with improved SNHL, and none experienced worsened SNHL during treatment. The mean VGCV Cmax was 3.5 μg/mL (range 2–5.3), with no significant variation among individual values, and the values were maintained during treatment. Furthermore, there were no correlations between the Cmax values and age, sex, SNHL improvement or ADEs. Neutropenia (<1000/mm3) was observed in six patients (23%); however, no serious ADEs occurred.ConclusionsVGCV prevented the progression of SNHL without serious ADEs due to its stable pharmacokinetics. This study provides safety and tolerability of VGCV for the treatment of cCMV patients. 相似文献
997.
Satoshi Kutsuna Yusuke Asai Kei Yamamoto Michinori Shirano Keiji Konishi Tomohiro Asaoka Masaya Yamato Yukiko Katsuragi Yudai Yamamoto Toshinori Sahara Aya Tamiya Fukumi Nakamura-Uchiyama Naoya Sakamoto Atsushi Kosaka Takuya Washino Ryota Hase Haruki Mito Takashi Kurita Norio Ohmagari 《Journal of infection and chemotherapy》2021,27(4):632-638
IntroductionThe epidemiology of infectious diseases in Japan remains undefined despite the increasing tourism. GeoSentinel, an epidemiological surveillance system for reporting imported infectious diseases, has only two participating facilities in Japan. Although the number of infectious diseases is reported by the National Institute of Infectious Diseases, there is no detailed clinical information about these cases. Therefore, we established J-RIDA (Japan Registry for Infectious Diseases from Abroad) to clarify the status of imported infectious diseases in Japan and provide detailed information.MethodsJ-RIDA was started as a registry of imported infectious diseases. Case registration began in October 2017. Between October 2017 and September 2019, 15 medical institutions participated in this clinical study. The registry collected information about the patient's age, sex, nationality, chief complaint, consultation date, date of onset, whether visit was made to a travel clinic before travel, blood test results (if samples were collected), travel history, and final diagnosis.ResultsOf the 3046 cases included in this study, 46.7% to Southeast Asia, 13.0% to Africa, 13.7% to East Asia, 11.5% to South Asia, 7.5% to Europe, 3.8% to Central and South America, 4.6% to North America, 3.9% to Oceania, and 2.8% to Central and west Asia. More than 85% of chief complaints were fever and general symptoms, gastrointestinal symptoms, respiratory symptoms, or dermatologic problems. The most common diseases were travelers’ diarrhea, animal bite, upper respiratory infection, influenza, and dengue fever.ConclusionsWe summarized two-year cases registered in Japan's imported infectious disease registry. These results will significantly contribute to the epidemiology in Japan. 相似文献
998.
Miwa Haruo Numata Kazushi Sugimori Kazuya Kaneko Takashi Maeda Shin 《Journal of Medical Ultrasonics》2021,48(2):159-173
Journal of Medical Ultrasonics - Ultrasound (US) is a cost-effective and noninvasive procedure without radiation exposure, with real-time evaluation and high spatial resolution. Although it is... 相似文献
999.
Takashi Ueda Yoshio Takesue Tetsuya Matsumoto Kazuhiro Tateda Shinya Kusachi Hiroshige Mikamo Junko Sato Hideaki Hanaki Toru Mizuguchi Keita Morikane Minako Kobayashi Yasushi Harihara Shiko Seki Yuichi Ishida Ryoji Fukushima Masahiro Hada Yoichi Matsuo Shoji Kubo Hideki Kawamura 《Journal of infection and chemotherapy》2021,27(7):931-939
Inappropriate antimicrobial therapy for surgical site infections (SSIs) can lead to poor outcomes and an increased risk of antibiotic resistance. A nationwide survey was conducted in Japan from 2018 to 2019 to investigate the antimicrobial susceptibility of pathogens isolated from SSIs. The data were compared with those obtained in 2010 and 2014–2015 surveillance studies. Although the rate of detection of extended-spectrum β-lactamase producing strains of Escherichia coli was increased from 9.5% in 2010 to 23% in 2014–2015, the incidence decreased to 8.7% in 2018–2019. Although high susceptibility rates were detected to piperacillin/tazobactam (TAZ), the geometric mean MICs were substantially higher than to meropenem (2.67 vs 0.08 μg/mL). By contrast, relatively low geometric mean MICs (0.397 μg/mL) were demonstrated for ceftolozane/TAZ. Although the MRSA incidence rate decreased from 72% in the first surveillance to 53% in the second, no further decrease was detected in 2018–2019. For the Bacteroides fragilis group species, low levels of susceptibility were observed for moxifloxacin (65.3%), cefoxitin (65.3%), and clindamycin (CLDM) (38.9%). In particular, low susceptibility against cefoxitin was demonstrated in non-fragilis Bacteroides, especially B. thetaiotaomicron. By contrast, low susceptibility rates against CLDM were demonstrated in both B. fragilis and non-fragilis Bacteroides species, and a steady decrease in susceptibility throughout was observed (59.3% in 2010, 46.9% in 2014–2015, and 38.9% in 2018–2019). In conclusion, Japanese surveillance data revealed no significant lowering of antibiotic susceptibility over the past decade in organisms commonly associated from SSIs, with the exception of the B. fragilis group. 相似文献