全文获取类型
收费全文 | 134篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
妇产科学 | 10篇 |
基础医学 | 7篇 |
口腔科学 | 1篇 |
临床医学 | 8篇 |
内科学 | 17篇 |
外科学 | 25篇 |
预防医学 | 40篇 |
药学 | 18篇 |
中国医学 | 7篇 |
肿瘤学 | 8篇 |
出版年
2022年 | 4篇 |
2021年 | 1篇 |
2019年 | 3篇 |
2018年 | 7篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 8篇 |
2013年 | 7篇 |
2012年 | 7篇 |
2011年 | 8篇 |
2009年 | 4篇 |
2008年 | 4篇 |
2007年 | 6篇 |
2006年 | 2篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2003年 | 6篇 |
2002年 | 5篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 5篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1968年 | 5篇 |
1967年 | 2篇 |
1966年 | 2篇 |
排序方式: 共有141条查询结果,搜索用时 15 毫秒
91.
92.
Georg Wiltberger Yan Wu Undine Lange Hans‐Michael Hau Elliot Tapper Felix Krenzien Georgi Atanasov Christian Benzing Linda Feldbrügge Eva Csizmadia Johannes Broschewitz Michael Bartels Daniel Seehofer Sven Jonas Thomas Berg Phillip Hessel Rudi Ascherl Ulf P. Neumann Johann Pratschke Simon C. Robson Moritz Schmelzle 《Alimentary pharmacology & therapeutics》2019,49(6):779-788
93.
94.
Anna Pitschmann Martin ZehlAtanas G. Atanasov Verena M. DirschElke Heiss Sabine Glasl 《Journal of ethnopharmacology》2014
Ethnopharmacological relevance
Walnut, Juglans regia L. (Juglandaceae), is one of the medicinal plants used to treat diabetic symptoms in Austrian folk medicine. The air-dried green leaves are either used as aqueous decoctions or liquor preparations and are consumed on a daily basis. We investigated the hypoglycemic effect of a methanolic Juglans regia leaf extract on glucose uptake, protein tyrosine phosphatase 1B (PTP1B) inhibition and peroxisome proliferator-activated receptor gamma (PPARγ) activation.Material and methods
Hypoglycemic activity was assessed by glucose-uptake in C2C12 myocytes, inhibition of PTP1B and activation of PPARγ. Phytochemical characterization of the extract was carried out by LC–MS and GC–MS.Results
Methanolic Juglans regia leaf extract enhanced the glucose uptake rate in C2C12 myocytes at concentrations of 25 µg/mL compared to untreated cells. This activity may partly be explained by the inhibition of PTP1B but not PPARγ agonism. LC–MS analyses revealed chlorogenic acid (1), 3-p-coumaroylquinic acid (2), a trihydroxynaphthalene-hexoside (3), as well as eight flavonoids (4–11) as main phenolic constituents in the active extract.Conclusions
The finding that Juglans regia leaf extract enhances glucose uptake and inhibits PTP1B provides an in vitro-based rationale for the traditional use of walnut leaf preparations against elevated blood-glucose levels. 相似文献95.
Prasanta Dey Amit Kundu Hirak Jyoti Chakraborty Babli Kar Wahn Soo Choi Byung Mu Lee Tejendra Bhakta Atanas G. Atanasov Hyung Sik Kim 《International journal of cancer. Journal international du cancer》2019,145(7):1731-1744
Discovery and development of new potentially selective anticancer agents are necessary to prevent a global cancer health crisis. Currently, alternative medicinal agents derived from plants have been extensively investigated to develop anticancer drugs with fewer adverse effects. Among them, steroidal alkaloids are conventional secondary metabolites that comprise an important class of natural products found in plants, marine organisms and invertebrates, and constitute a judicious choice as potential anti-cancer leads. Traditional medicine and modern science have shown that representatives from this compound group possess potential antimicrobial, analgesic, anticancer and anti-inflammatory effects. Therefore, systematic and recapitulated information about the bioactivity of these compounds, with special emphasis on the molecular or cellular mechanisms, is of high interest. In this review, we methodically discuss the in vitro and in vivo potential of the anticancer activity of natural steroidal alkaloids and their synthetic and semi-synthetic derivatives. This review focuses on cumulative and comprehensive molecular mechanisms, which will help researchers understand the molecular pathways involving steroid alkaloids to generate a selective and safe new lead compound with improved therapeutic applications for cancer prevention and therapy. In vitro and in vivo studies provide evidence about the promising therapeutic potential of steroidal alkaloids in various cancer cell lines, but advanced pharmacokinetic and clinical experiments are required to develop more selective and safe drugs for cancer treatment. 相似文献
96.
Vasil N. Atanasov Kamen P. Kanev Mariana Io. Mitewa 《Central European Journal of Medicine》2008,3(3):327-331
Quetiapine fumarate (Seroquel®) is an atypical antipsychotic dibenzothiazepine derivative. Due to its extensive hepatic metabolism and low level of unchanged excretion (< 1%) the routine toxicological drug-screening analyses of urine often leads to false negative results. In the present study, we report that a newly identified metabolite of quetiapine, N-desalkylquetiapine, can be used as an indicative marker of quetiapine-intake in urine using common GC-MS screening procedure. The structure of the mentioned metabolite was solved from the mass-spectrum obtained and the quetiapine presence was proved by consequent HPLC plasma analysis. 相似文献
97.
98.
Mathias Teichmann Nicole Kretschy Sabine Kopf Kanokwan Jarukamjorn Atanas G. Atanasov Katharina Viola Benedikt Giessrigl Philipp Saiko Thomas Szekeres Wolfgang Mikulits Verena M. Dirsch Nicole Huttary Sigurd Krieger Walter Jäger Michael Grusch Helmut Dolznig Georg Krupitza 《Archives of toxicology》2014,88(3):691-699
Metastatic breast cancer is linked to an undesired prognosis. One early and crucial metastatic step is the interaction of cancer emboli with adjacent stroma or endothelial cells, and understanding the mechanisms of this interaction provides the basis to define new targets as well as drugs for therapy and disease management. A three-dimensional (3D) co-culture model allowing the examination of lymphogenic dissemination of breast cancer cells was recently developed which facilitates not only the study of metastatic processes but also the testing of therapeutic concepts. This 3D setting consists of MCF-7 breast cancer cell spheroids (representing a ductal and hormone-dependent subtype) and of hTERT-immortalised lymph endothelial cell (LEC; derived from foreskin) monolayers. Tumour spheroids repel the continuous LEC layer, thereby generating “circular chemorepellent-induced defects” (CCIDs) that are reminiscent to the entry gates through which tumour emboli intravasate lymphatics. We found that the ion channel blocker carbamazepine (which is clinically used to treat epilepsy, schizophrenia and other neurological disorders) inhibited CCID formation significantly. This effect correlated with the inhibition of the activities of NF-κB, which contributes to cell motility, and with the inactivation of the mobility proteins MLC2, MYPT1 and FAK which are necessary for LEC migration. NF-κB activity and cell movement are prerequisites of CCID formation. On the other hand, the expression of the motility protein paxillin and of the NF-κB-dependent adhesion mediator ICAM-1 was unchanged. Also the activity of ALOX12 was unaffected. ALOX12 is the main enzyme synthesising 12(S)-HETE, which then triggers CCID formation. The relevance of the inhibition of CYP1A1, which is also involved in the generation of mid-chain HETEs such as 12(S)-HETE, by carbamazepine remains to be established, because the constitutive level of 12(S)-HETE did not change upon carbamazepine treatment. Nevertheless, the effect of carbamazepine on the inhibition of CCID formation as an early step of breast cancer metastasis was significant and substantial (~30 %) and achieved at concentrations that are found in the plasma of carbamazepine-treated adults (40–60 μM). The fact that carbamazepine is a drug approved by the US Food and Drug Administration facilitates a “from-bench-to-bedside” perspective. Therefore, the here presented data should undergo scrutiny in vivo. 相似文献
99.
100.