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排序方式: 共有2606条查询结果,搜索用时 15 毫秒
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Alexandre Lafont MD Peter R Sinnaeve MD PhD Thomas Cuisset MD PhD Stéphane Cook MD PhD Giorgios Sideris MD PhD Sasko Kedev MD PhD Didier Carrie MD PhD Thomas Hovasse MD Philippe Garot MD Rami El Mahmoud MD Christian Spaulding MD Gérard Helft MD PhD José F Diaz Fernandez MD Salvatore Brugaletta MD Eduardo Pinar-Bermudez MD Josepa Mauri Ferre MD Philippe Commeau MD Emmanuel Teiger MD PhD Kris Bogaerts MD PhD Manel Sabate MD PhD Marie Claude Morice MD Olivier Varenne MD PhD for the SENIOR investigators 《Catheterization and cardiovascular interventions》2021,97(5):E607-E613
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Armstrong DS Hook SM Jamsen KM Nixon GM Carzino R Carlin JB Robertson CF Grimwood K 《Pediatric pulmonology》2005,40(6):500-510
Controversy exists over whether the lower airway inflammation that characterizes cystic fibrosis (CF) is initiated primarily by the genetic defect. To determine if inflammation precedes infection, we examined bronchoalveolar lavage (BAL) fluid cytology, cytokines (interleukin (IL)-1beta, IL-4, IL-5, IL-6, IL-8, IL-10, and tumor necrosis factor-alpha), and free neutrophil elastase activity from 70 CF (aged 1.5-71 months) children detected by newborn screening and 19 (aged 2.0-48 months) controls with chronic stridor. CF subjects were selected and categorized as pristine (13 aged = 6 months, lacking prior respiratory symptoms and exposure to antibiotics, and without respiratory pathogens on BAL), infected (42 with viruses or >/= 10(5) colony-forming units/ml of pathogenic bacteria in BAL), and uninfected (15 aged > 6 months, asymptomatic, not taking antibiotics at bronchoscopy, and free of pathogens in their BAL). To further resolve if inflammation develops without infection, inflammatory mediators in paired annual BAL samples from 38 CF subjects were measured, and results were grouped according to whether BAL showed persistence (n = 6), acquisition (n = 8), clearance (n = 13), or absence (n = 11) of infection. While pristine, uninfected, and control subjects had similar BAL profiles, infected patients showed elevated inflammatory indices, including increased IL-10 (P < 0.001). Pristine subjects had the fewest signs of inflammation. Analysis of BAL pairs found differences between the four infection groups for changes in neutrophil percentages, IL-8 (P < 0.001), and free neutrophil elastase (P = 0.009). Infection was associated with elevated inflammatory mediators in BAL fluid. In contrast, minimal or reduced signs of inflammation accompanied absence of eradication of infection from BAL fluid. We conclude that in CF, infection initiates and sustains airway inflammation. 相似文献
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Agamemnon Pericleous Mostafa Sadek Mary Fitzmaurice Constance Caldwell Kris Natividad Konstadinos A. Plestis 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2014,41(6):645-648
Heparin-induced thrombocytopenia is a well-recognized complication of anticoagulation with heparin. We present the case of a patient with recent heparin-induced thrombocytopenia who subsequently needed surgery on an emergency basis for acute type A aortic dissection. This article reports the successful use of bivalirudin, a direct thrombin inhibitor, as an alternative to heparin throughout cardiopulmonary bypass and deep hypothermic circulatory arrest. We contend that bivalirudin is a safe alternative to heparin when performing surgery for aortic dissection and should be considered as an option for use in patients who present with heparin-induced thrombocytopenia. 相似文献
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Kris?EversEmail author Sven?Panis Katrien?Torfs Jean?Steyaert Ilse?Noens Johan?Wagemans 《Journal of autism and developmental disorders》2014,44(4):801-815
Atypical visual processing in children with autism spectrum disorder (ASD) does not seem to reside in an isolated processing component, such as global or local processing. We therefore developed a paradigm that requires the interaction between different processes—an identification task with Gaborized object outlines—and applied this to two age groups of 6-to-10 and 10-to-14 year old children with and without ASD. Event history analyses demonstrated an identification disadvantage in the ASD group, which remained quite stable during the temporal unfolding of the outline. The typically developing group particularly outperformed the ASD group when more complex contours were shown. Together, our results suggest that the interplay between local and global processes and between bottom-up and top-down processes is disturbed in ASD. 相似文献
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