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排序方式: 共有3234条查询结果,搜索用时 15 毫秒
91.
Suhayl Dhib-Jalbut Sumandeep Sumandeep Reuben Valenzuela Kouichi Ito Payal Patel Mark Rametta 《Journal of neuroimmunology》2013,254(1-2):131-140
We measured immune markers in subjects with multiple sclerosis (MS) treated with IFNβ-1b for 12 months. IL-17 levels were significantly higher at Month 6 (p = 0.036) in relapsing subjects while BDNF levels were significantly higher at Month 3 (p = 0.028) in relapse-free subjects. Change from baseline in IL-4 levels inversely correlated with disability score whereas change from baseline in IL-10/IFN-gamma ratio inversely correlated with occurrence of relapses. CXCR3 + CD8 + T-cells tended to be higher but declined with treatment in relapse-free compared with relapsing subjects. Findings show the potential of cytokine and neurotrophic factors as biomarkers of clinical response to IFNβ-1b. 相似文献
92.
Uno Takehiro Misaki Kouichi Futami Kazuya Nambu Iku Yoshikawa Akifumi Kamide Tomoya Uchiyama Naoyuki Nakada Mitsutoshi 《Neurological sciences》2022,43(3):1849-1857
Neurological Sciences - Although bleb formation increases the risk of rupture of intracranial aneurysms, previous computational fluid dynamic (CFD) studies have been unable to identify robust... 相似文献
93.
Sato Ryosuke Matsuzawa Yasushi Ogawa Hisao Kimura Kazuo Tsuboi Nobuo Yokoo Takashi Okada Hirokazu Konishi Masaaki Kirigaya Jin Fukui Kazuki Tsukahara Kengo Shimizu Hiroyuki Iwabuchi Keisuke Yamada Yu Saka Kenichiro Takeuchi Ichiro Kashihara Naoki Tamura Kouichi 《Clinical and experimental nephrology》2022,26(10):974-981
Clinical and Experimental Nephrology - Identifying predictive factors for coronavirus disease 2019 (COVID-19) is crucial for risk stratification and intervention. Kidney dysfunction contributes to... 相似文献
94.
Komiya Shiro Katsumata Mari Ozawa Moe Haze Tatsuya Kawano Rina Ohki Yuki Suzuki Shota Kobayashi Yusuke Fujiwara Akira Saka Sanae Tamura Kouichi Hirawa Nobuhito 《Clinical and experimental nephrology》2022,26(9):851-858
Clinical and Experimental Nephrology - Tolvaptan (TLV) is reported to improve diuretic effects in patients with chronic kidney disease (CKD) when furosemide (FUR) is not sufficiently effective.... 相似文献
95.
BACKGROUND: Excessive thinness has been glamorized among Japanese adolescent girls, and unhealthy dieting to lose weight has become a popular practice among them. The prevalence of underweight in contemporary Japanese girls in comparison with that of boys, however, remains to be studied. AIM: The purpose of this study was to determine the prevalence and trends of underweight in contemporary Japanese teenagers of both sexes using nationally representative cross-sectional data. SUBJECTS AND METHODS: Underweight was defined as BMI < 3rd percentile by age and sex of the 1978-1981 reference population as previously reported. These reference values were compared with BMIs of the contemporary population based on the 2001 Cross-sectional National Survey data of Japanese teenagers (215 972 boys and 216 496 girls). RESULTS: The prevalence of underweight was approximately 2-3% in junior high school students of both sexes, 12.5-14.5 years of age, approximately 3% in senior high school students of both sexes, 15.5-16.5 years of age, and approximately 4% in senior high school students of both sexes, 17.5 years of age. CONCLUSION: The prevalence of underweight decreased among Japanese teenage students of both sexes during the past decades. Female preponderance in the prevalence of underweight was not confirmed. 相似文献
96.
Ohkawa N Hashimoto K Hino T Migishima R Yokoyama M Kano M Inokuchi K 《Neuroscience research》2007,59(1):93-100
The proper regulation of microtubule (MT) structure is important for dendritic and neural circuit development. However, the relationship between the regulation of the MTs in dendrites and the formation of neural function is still unclear. Stathmin is a MT destabilizer, and we have previously reported that the expression and the activity of stathmin is downregulated during cerebellar Purkinje cell (PC) development. In this study, we generated transgenic mice that specifically overexpress the constitutively active form of stathmin in the PCs. These mutant mice did not show any obvious morphological or excitatory transmission abnormalities in the cerebellum. In contrast, we observed a decline in the expression of MAP2 and KIF5 signal in the PC dendrites and a discoordination of motor function in the mutant mice, although they displayed normal general behavior. These data indicate that the overexpression of stathmin disrupts dendritic MT organization, motor protein distribution, and neural function in PCs. 相似文献
97.
Miyazaki K Kikukawa M Kiuchi A Shin K Iwamoto T Ohyashiki K 《Cancer Genetics and Cytogenetics》2007,176(2):127-130
We report the case of an elderly man with an acute promyelocytic leukemia variant carrying complex variant translocations. The Q-banded karyotype and spectral karyotyping method revealed a typical t(15;17), and two complex rearrangements caused by stepwise translocation derived from a typical t(15;17). Chromosomes 8 and 14 were related to these rearrangements. The patient received induction chemotherapy using all-trans retinoic acid and achieved complete remission. To our knowledge, a case with complex rearrangements, caused by apparent stepwise translocation, at diagnosis, has not been reported previously. 相似文献
98.
Horiguchi S Matsuoka T Okamoto Y Sakurai D Kobayashi K Chazono H Hanazawa T Tanaka Y 《Journal of clinical immunology》2007,27(6):598-604
Tumor-specific peptide-pulsed dendritic cells (DC) were administered via different routes to a group of patients with head
and neck cancers. The migration and homing patterns of such antigen-stimulated cells was carefully studied employing single
photon emission computed tomography (SPECT). The DC administered directly into the nasal submucosa quickly migrated very rapidly
to the regional neck lymph nodes in the neck. However, after inoculation of the cells into the palatine tonsils, the DCs remained
close to the site of administration and did not migrate to the regional lymph nodes or to other mucosal regions. After nasal
submucosal administration of the DC, tumor-antigen-specific cytotoxic T cells were detected in the ipsilaterals but not in
the contra lateral lymph nodes. These results suggest that after antigen processing, the regional lymph nodes serve as inductive
sites for development of mucosal immune responses and for induction of memory cells during the local immunological responses
in the nasopharyngeal-associated lymphoid tissue in man. 相似文献
99.
Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis 总被引:1,自引:0,他引:1 下载免费PDF全文
Hashimoto T Kihara M Imai N Yoshida S Shimoyamada H Yasuzaki H Ishida J Toya Y Kiuchi Y Hirawa N Tamura K Yazawa T Kitamura H Fukamizu A Umemura S 《The American journal of pathology》2007,171(5):1705-1712
The recently identified endogenous peptide apelin and its specific apelin receptor (APJ) are currently being considered as potential regulators in vascular tissue. Previously, we reported apelin mediates phosphorylation of myosin light chain and elicits vasoconstriction in vascular smooth muscle. In this study, physiological roles of the apelin-APJ system were investigated on atherosclerosis. In APJ and apolipoprotein E double-knockout (APJ(-/-)ApoE(-/-)) mice fed a high-cholesterol diet, atherosclerotic lesions were dramatically reduced when compared with APJ(+/+) ApoE(-/-) mice, in the absence of an effect of cholesterol levels. Immunohistochemical detection of smooth muscle cells, using a smooth muscle alpha-actin antibody, showed greatly reduced staining for these cells in lesions of APJ(-/-)ApoE(-/-) mice fed a high-cholesterol diet. Vascular production of superoxide radicals and the expression of nicotinamide-adenine dinucleotide phosphate oxidase subunits were decreased in APJ(-/-)ApoE(-/-) mice compared with APJ(+/+)ApoE(-/-) mice fed a standard normal diet. In vascular smooth muscle cells, apelin induced nicotinamide-adenine dinucleotide phosphate oxidase subunit expression. Apelin also induced vascular smooth muscle cell proliferation, which was inhibited by superoxide dismutase or diphenylene iodonium. The apelin-APJ system is a mediator of oxidative stress in vascular tissue, and thus we propose it to be a critical factor in atherogenesis under high-cholesterol dietary conditions. APJ deficiency is preventative against oxidative stress-linked atherosclerosis. 相似文献
100.
Mika Nagai Takuomi Hosaka Masahiro Satsukawa Kouichi Yoshinari 《Journal of pharmaceutical sciences》2018,107(9):2479-2488
CYP2C enzymes play key roles in drug metabolism, and clinical drug-drug interactions caused by CYP2C induction have been reported. The aim of this study was to establish a method to predict the potency of CYP2C inductions considering the mechanism. We first investigated the relations of CYP2C induction with CYP3A4 or CYP2B6 induction in human hepatocytes after 48-h exposure with 19 inducers. The fold-induction values of CYP2C8 and CYP2C9 were well correlated with those of CYP3A4, whereas the inducers were separated into 2 groups showing different correlations with CYP2B6 induction for CYP2C8 and CYP2C9 induction. In the regression models established, the fold-induction values of CYP2C8 and CYP2C9 were well expressed as the functions of those of CYP3A4 and CYP2B6, while no such obvious correlation was observed for CYP2C19 induction. These results suggest that CYP2Cs are not simply coinduced with CYP3A4 and that CYP2C8 and CYP2C9 inductions are regulated by both pregnane X receptor and constitutive androstane receptor with different contributions. Finally, simple correlations were proposed using the experimental Emax values obtained and plasma concentrations of CYP2C9 substrates from the literature, and positive correlations were observed. These data provide methods to estimate the clinical impact of CYP2C9 induction from in vitro data. 相似文献