麻痹性斜视183例临床分析

目的:探讨近年来麻痹性斜视的病因、麻痹肌分布和对视功能的影响。方法:对我院2009-03/2012-03住院行斜视矫正术的183例麻痹性斜视患者的病历资料进行回顾性研究。结果:先天性麻痹性斜视占80.87%,后天性麻痹性斜视占19.13%;原因不明者最多(77.60%),其次为外伤(14.21%)。垂直斜视中上斜肌麻痹占81.19%,下直肌麻痹占8.26%,上直肌麻痹占6.88%,下斜肌麻痹占2.29%,双上转肌麻痹占0.92%,双下转肌麻痹占0.46%。水平斜视中外直肌麻痹占54.17%,内直肌麻痹占45.83%。166例患者术前进行同视机检查,有双眼视功能患者占28.92%。结论:麻痹性斜视病因复杂,眼外肌中上斜肌最常累及,对双眼视功能有明显的影响,应尽早进行手术治疗。     

Fertility regulating agents from traditional Chinese medicines

Chinese scientists have capitalized on the rich flora and the ethnomedical experience in China, in their pursuit of fertility regulating agents from natural products. Discoveries range from anti-implantation agents to abortifacient and pregnancy-terminating compounds, as well as a male contraceptive. Chemistry and bioactivity of these compounds and materials are reviewed in this paper, with the hope that further research and collaboration will take place to help solve the problem of population explosion.     

Emerging Roles of Human Prostatic Acid Phosphatase

Prostate cancer is one of the most prevalent non-skin related cancers. It is the second leading cause of cancer deaths among males in most Western countries. If prostate cancer is diagnosed in its early stages, there is a higher probability that it will be completely cured. Prostatic acid phosphatase (PAP) is a non-specific phosphomonoesterase synthesized in prostate epithelial cells and its level proportionally increases with prostate cancer progression. PAP was the biochemical diagnostic mainstay for prostate cancer until the introduction of prostate-specific antigen (PSA) which improved the detection of early-stage prostate cancer and largely displaced PAP. Recently, however, there is a renewed interest in PAP because of its usefulness in prognosticating intermediate to high-risk prostate cancers and its success in the immunotherapy of prostate cancer. Although PAP is believed to be a key regulator of prostate cell growth, its exact role in normal prostate as well as detailed molecular mechanism of PAP regulation is still unclear. Here, many different aspects of PAP in prostate cancer are revisited and its emerging roles in other environment are discussed.     

小檗胺在升高白细胞的同时对乳酸脱氢酶的影响

采用酶细胞化学及平板聚丙烯酰胺凝胶电泳法观察小檗胺(Ber)在升高白细胞的同时,是否对细胞内酶代谢及其同工酶有影响。结果表明:ip Ber的小鼠粒细胞内LDH酶反应明显增强,酶反应的强弱与用药时间长短成正比。LDH同工酶谱分析,所有标本均显示5条区带,LDH_2比例发生变化,对照组及Ber组中出现LDH’_5亚带。提示,Ber在升高白细胞的同时对细胞内酶的代谢有一定影响,同时伴有同工酶谱比例改变。     

胆碱乙酰化酶在人体耳蜗的定位

应用免疫细胞化学方法，研究胆碱乙酰化酶在人体耳蜗的定位。结果发现，胆碱乙酰化酶定位于人体耳蜗传出神经系统。实验表明，乙酰胆碱是人体耳蜗的传出神经递质     

Template-Mediated Synthesis of Hierarchically Porous Metal–Organic Frameworks for Efficient CO2/N2 Separation

Carbon dioxide (CO₂) is generally unavoidable during the production of fuel gases such as hydrogen (H₂) from steam reformation and syngas composed of carbon monoxide (CO) and hydrogen (H₂). Efficient separation of CO₂ from these gases is highly important to improve the energetic utilization efficiency and prevent poisoning during specific applications. Metal–organic frameworks (MOFs), featuring ordered porous frameworks, high surface areas and tunable pore structures, are emerging porous materials utilized as solid adsorbents for efficient CO₂ capture and separation. Furthermore, the construction of hierarchical MOFs with micropores and mesopores could further promote the dynamic separation processes, accelerating the diffusion of gas flow and exposing more adsorptive pore surface. Herein, we report a simple, efficient, one-pot template-mediated strategy to fabricate a hierarchically porous CuBTC (CuBTC-Water, BTC = 1,3,5-benzenetricarboxylate) for CO₂ separation, which demonstrates abundant mesopores and the superb dynamic separation ability of CO₂/N₂. Therefore, CuBTC-Water demonstrated a CO₂ uptake of 180.529 cm³ g⁻¹ at 273 K and 1 bar, and 94.147 cm³ g⁻¹ at 298 K and 1 bar, with selectivity for CO₂/N₂ mixtures as high as 56.547 at 273 K, much higher than microporous CuBTC. This work opens up a novel avenue to facilely fabricate hierarchically porous MOFs through one-pot synthesis for efficient dynamic CO₂ separation.     

HMG-CoA还原酶抑制剂对X综合征血管内皮功能的影响

目的 :通过应用HMG -CoA还原酶抑制剂 (普伐他汀 )对x综合浆内征患者的血管内皮功能的影响 ,观察微血管病变引起的心肌缺血的改善作用。方法 :严格筛选 17例临床表现为胸痛并已作冠脉造影正常的患者服用普伐他汀 10mg。每晚睡前服 1次 ,疗程 3个月 ,用药前后进行血浆内皮素 (ET)的检测及活动平板运动试验 ,比较用药前后各项指标的变化情况。结果 :血浆ET水平较治疗前明显降低 (P <0 .0 1) ,运动出现心绞痛ST段改变的时间明显延长 (P <0 .0 5 ) ;ST段恢复时间显著缩短 (P <0 .0 5 )运动后 4分时相各导联运动诱发的ST段缺血型下降之和 (∑ST)明显减少。结论 :HMG -CoA还原酶抑制剂 (普伐他汀 )可显著改善X综合征患者的血管内皮功能异常 ,减轻心肌缺血 ,对X综合征有治疗作用     

聚维酮在阿霉素诱导膀胱癌EJ细胞凋亡模型中的作用机制

目的:探讨聚维酮(PVP)在体外加阿霉素(ADM)后诱导EJ细胞发生凋亡的情况以及一些相关机制。方法:应用流式细胞仪(FCM)检测ADM诱导EJ细胞的凋亡率、PVP EJ细胞的凋亡率以及PVP ADM对EJ细胞的诱导凋亡率的情况。结果:PVP对ADM诱导膀胱癌EJ细胞凋亡无影响。结论:PVP在整个诱导过程中并没有协同作用,只起到粘附作用,使得药物停留在EJ细胞表面的作用时间延长,从而达到大量杀伤EJ细胞的作用。