经前路行颈椎后纵韧带骨化切除33例

对Ｃ_４水平以下节段性颈椎后纵韧带骨化（ＯＰＬＬ）３３例行前路骨化韧带切除术。２９例随访１～１０ａ，按ＪＯＡ标准评定疗效。结果：优（术后改善率８０％以上）１３例；良（５０％～７９％）１０例；改进（５％～４９％）３例；无变化（５％以下）２例；加重１例，有效率８９．６％。提示：Ｃ_４以下节段性ＯＰＬＬ适合前路开槽切除；Ｃ_４以上的节段性ＯＰＬＬ或连续型ＯＰＬＬ适合后路椎板成形椎管扩大术。充分暴露骨化灶的范围，才能将其完整切除。     

Determinants of Short-Term Weight Gain Following Surgical Treatment for Craniopharyngioma in Adults

ObjectiveCraniopharyngiomas (CPs) are associated with hypothalamic damage that causes hypothalamic obesity, however, the mechanisms underlying CP-related postoperative weight gain remain debatable. This study aimed to elucidate whether the major determinant of postoperative weight gain in patients with CP is hypothalamic injury or steroid replacement therapy. MethodsWe included 48 adult patients with CP (age ≥18 years) who underwent transsphenoidal surgery between 2010 and 2018 in a single tertiary center, and whose body weight was measured pre- and postoperatively (<120 days after the surgery). We recruited 144 age- and body mass index-matched patients with non-functioning pituitary adenoma (NFPA) as controls. ResultsPatients with CP experienced greater postoperative weight gain than patients with NFPA (3.0±5.1 vs. 0.1±3.6 kg, p<0.001). The prevalence of postoperative steroid use was significantly higher in patients with CP than in those with NFPA (89.6% vs. 34.0%, p<0.001). Steroid replacement therapy and CP were associated with postoperative weight gain after adjusting for covariates in overall patients (p=0.032 and 0.007, respectively). In subgroup analysis with postoperative steroid users, weight gain was significantly greater in patients with CP (n=43, 0.96±0.25 kg/month) than in patients with NFPA (n=49, 0.26±0.23 kg/month) even after adjusting for the daily steroid dose (p=0.048). ConclusionPatients with CP experience greater postoperative weight gain than those with NFPA. Hypothalamic damage itself as well as steroid replacement may contribute to the postoperative weight gain in patients with CP.     

IGF-I对子宫切除所致大鼠卵巢颗粒细胞凋亡的抑制作用

目的 探讨IGF-I对子宫切除所致大鼠卵巢颗粒细胞凋亡的抑制作用。方法 采用子宫切除术方法建立子宫切除Sprague-Dawley大鼠模型(保留卵巢)。向体外培养的子宫切除大鼠卵巢颗粒细胞施加60ng刖浓度外源性IGF-I。应用流式细胞仪检测细胞凋亡率。应用荧光显微镜观察细胞凋亡形态学特征。结果 模型组(子宫切除)较正常组(子宫未切除)凋亡增加;IGF-I组(子宫切除 IGF-I)能减缓子宫切除引起的凋亡升高。结论 外源性IGF-I抑制子宫切除大鼠卵巢颗粒细胞凋亡。     

Lipomatous meningioma: Diagnostic pitfalls and pathological updates

We present a case of histologically confirmed lipomatous meningioma, the first to our knowledge reported in Hong Kong. A 75‐year‐old woman presented to us with on and off dizziness for 1 month. Computed tomography (CT) of the brain showed an extra‐axial mass lesion containing fat and solid enhancing foci at her right frontal region. The definitive diagnosis could be made preoperatively. Postoperative histological examination of the tumour revealed the diagnosis of lipomatous meningioma. We have reviewed the literature and discussed the diagnostic clues, clinical presentation and pathology of this rare tumour.     

A study on improvement of expression of human G－CSF cDNA transferred with retroviral double－copy vector

ＡｓｔｕｄｙｏｎｉｍｐｒｏｖｅｍｅｎｔｏｆｅｘｐｒｅｓｓｉｏｎｏｆｈｕｍａｎＧ－ＣＳＦｃＤＮＡｔｒａｎｓｆｅｒｒｅｄｗｉｔｈｒｅｔｒｏｖｉｒａｌｄｏｕｂｌｅ－ｃｏｐｙｖｅｃｔｏｒＧｕｏＢａｏｙｕ（郭葆玉）；ＺｈａｎｇＳｕｙｉｎｇ（张淑英）；ＸｕＨｕｉ...