Teratologic evaluation of Alcide liquid in rats and mice. I

Alcide, a liquid sterilizer, was evaluated for teratogenic potential in rats and mice. Sodium chlorite and lactic acid, the active ingredients of this compound, form chlorine dioxide when mixed. Pregnant rats and mice were administered 1 ml and 0.1 ml, respectively, of Alcide liquid by gavage on days 6-15 of gestation. The general health of the dams was evaluated and the fetuses examined for external, visceral and skeletal malformations. There was no evidence of maternal toxicity among treated rats and mice. Fetal viability, weight, length and number of resorptions were comparable with control groups. Teratogenic toxicity was not detected in either species. There was some incidence of skeletal and visceral anomalies; however, these variances were not significantly different from control animals.     

Ein Latex-Agglutinationstest (LA-Test) zur Typenbestimmung von Enteroviren

Zusammenfassung In vorliegender Arbeit wird ein Latex-Agglutinationstest zum Nachweis und zur Typenbestimmung von Enteroviren beschrieben. In der Gewebekultur vermehrte Enteroviren konnten ohne vorherige Konzentration oder Reinigung typisiert werden. Zur Sensibilisierung der Latexpartikeln dienten -Globuline aus Hyperimmunseren gegen Poliovirus Typ 1, Coxsackievirus Typ A9, B4, B5 und Echovirus Typ 9.

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A latex agglutination test for typing enteroviruses

Summary A Latex agglutination test for the identification and typing of enteroviruses is described. Enteroviruses grown in tissue cultures could be tested without previous concentration or purification. For the sensibilization of Latex particles IgG fractions from hyperimmune sera against poliovirus type 1, Coxsackievirus type A9, B4, B5 and Echovirus type 9 were used.

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Wir danken Herrn Prof. Dr. R. Bercks und Frau Gertrud Querfurth, Biologische Bundesanstalt für Land- und Forstwirtschaft, Institut für Virusserologie, Braunsehweig, für wertvolle Hinweise bei der Erarbeitung des Testes, Herrn Volker Thieme und Fräulein Angela Kammerlander für technische Assistenz.     

Zur Wertigkeit der Phonokardiographie und einiger anderer Untersuchungsverfahren in der postoperativen Beurteilung angeborener Angiokardiopathien

Zusammenfassung An Hand eines größeren Krankengutes von bereits operierten, angeborenen Herzfehlern werden die postoperativen klinischen Befunde (Ekg, PKG und Röntgenbild) besprochen. Durch Nachkatheterisierungen wurde das klinische Bild mit der Hämodynamik korreliert und auf seine Wertigkeit geprüft.Dabei fand sich, daß bei der isolierten Pulmonalstenose, beim persistierenden Ductus Botalli und eventuell auch beim Ventrikelseptumdefekt die klinische Nachuntersuchung den Herzkatheterismus ersetzen kann, da genügend genaue Kriterien für die Beurteilung des Operationserfolges existieren.Bei der Aortenstenose, dem Vorhofseptumdefekt und dem Mb. Fallot hingegen empfiehlt es sich, bei Persistieren oder Wiederauftreten von Beschwerden eine Nachkatheterisierung vorzunehmen und im Fall von Scheidewanddefekten auch die Wasserstoff-Platin Technik anzuwenden, um die hämodynamischen Verhältnisse abzuklären und die Indikation zu einer eventuell notwendigen Reoperation zu stellen.

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Summary On a greater number of patients who have been operated on congenital anomalies of the heart the postoperative clinical findings (ecg, peg and chest x-ray) are discussed. They were correlated with the hemodynamic data by repeated cardiac catheterization.It was found that in patients with pulmonary stenosis, persistent Ductus arterious and ventricular septal defects the postoperative clinical examination is sufficiently accurate for the estimation of the operative results.On the other hand, in aortie stenosis, atrial septal defect and tetralogy of Fallot patients should be catheterized again if complaints persist or appear again. In patients with septal defects the hydrogen technic should be used to detect small residual shunts.

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Mit 7 Abbildungen in 11 Einzeldarstellungen und 1 Tabelle     

SURFACE MARKERS ON HUMAN B AND T LYMPHOCYTES : II. PRESENCE OF EPSTEIN-BARR VIRUS RECEPTORS ON B LYMPHOCYTES

Human peripheral lymphocytes were investigated for receptors binding Epstein-Barr virus (EBV) because of the regular association of this virus with infectious mononucleosis and Burkitt's lymphoma. This was done by a cytoadherence technique where virus-producing cells, displaying fresh viral determinants in their cytoplasmatic membrane, were mixed with lymphocytes. Unfractionated lymphocytes were found to adhere to these cells in contrast to column-purified T lymphocytes. The specificity of the binding was confirmed by blocking experiments that showed that sera containing high titers of antibodies directed against the virus could partially inhibit the adherence in contrast to low-titer sera. It is concluded that B lymphocytes, in contrast to T lymphocytes, have receptors for EBV. In a second line of experiments it was found that established human lymphoblastoid lines that carry the EBV genome had receptors characteristic for B lymphocytes and did not form T-lymphocyte rosettes. In contrast, a line of known T-lymphocyte origin that did not carry the EBV genome had receptors characteristic for T lymphocytes. EBV-transformed simian lymphoblastoid lines had surface markers indicating a B-lymphocyte origin in contrast to HVS-transformed simian lines that lacked surface immunoglobulin but carried receptors for sheep red blood cells.     

Synthesis and pharmacological activities of cyclic analogues of fentanyl (author's transl)]

Synthesis and Pharmacological Activities of Cyclic Analogues of Fentanyl . Cyclic analogues of fentanyl were synthesized and pharmacologically tested. Cyclisation of the acyl group with C-2 of the aromatic ring yielded a change in stereochemical structure. Therefore the analgesic activity of fentanyl was lost and strong antihistaminic activities appeared.