首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3760453篇
  免费   322358篇
  国内免费   14079篇
耳鼻咽喉   52250篇
儿科学   119723篇
妇产科学   96633篇
基础医学   593462篇
口腔科学   103187篇
临床医学   342380篇
内科学   669210篇
皮肤病学   96211篇
神经病学   318875篇
特种医学   150254篇
外国民族医学   354篇
外科学   582295篇
综合类   111501篇
现状与发展   24篇
一般理论   2351篇
预防医学   318713篇
眼科学   87281篇
药学   261993篇
  21篇
中国医学   10238篇
肿瘤学   179934篇
  2021年   55355篇
  2020年   35289篇
  2019年   58373篇
  2018年   72242篇
  2017年   54702篇
  2016年   60456篇
  2015年   74365篇
  2014年   108827篇
  2013年   173997篇
  2012年   99975篇
  2011年   102170篇
  2010年   119553篇
  2009年   122925篇
  2008年   89271篇
  2007年   93827篇
  2006年   103677篇
  2005年   99163篇
  2004年   101019篇
  2003年   91809篇
  2002年   81205篇
  2001年   127663篇
  2000年   122015篇
  1999年   116021篇
  1998年   68083篇
  1997年   64985篇
  1996年   63294篇
  1995年   58940篇
  1994年   52918篇
  1993年   49391篇
  1992年   84062篇
  1991年   81535篇
  1990年   78020篇
  1989年   76348篇
  1988年   70614篇
  1987年   69191篇
  1986年   65507篇
  1985年   65180篇
  1984年   56859篇
  1983年   51101篇
  1982年   44630篇
  1981年   41841篇
  1980年   39431篇
  1979年   48416篇
  1978年   41004篇
  1977年   36722篇
  1976年   34072篇
  1975年   33657篇
  1974年   35917篇
  1973年   34299篇
  1972年   32317篇
排序方式: 共有10000条查询结果,搜索用时 62 毫秒
171.
Erosive pustular dermatosis of the scalp (EPDS) is an uncommon chronic inflammatory response to scalp trauma that usually resolves with cicatricial alopecia. It most commonly affects elderly patients with a history of actinic damage. Herein, we describe a 16‐year‐old girl with acrofacial dysostosis type 1 presenting after surgery with crusting purulent scalp lesions, whose clinical presentation and histopathologic findings were consistent with EPDS. A review of the literature on EPDS in children is also detailed.  相似文献   
172.
173.
174.
175.
176.

Objective

Comparative survival between neoadjuvant chemotherapy and adjuvant chemotherapy for patients with cT2-4N0-1M0 non–small cell lung cancer has not been extensively studied.

Methods

Patients with cT2-4N0-1M0 non–small cell lung cancer who received platinum-based chemotherapy were retrospectively identified. Exclusion criteria included stage IV disease, induction radiotherapy, and targeted therapy. The primary end point was disease-free survival. Secondary end points were overall survival, chemotherapy tolerance, and ability of Response Evaluation Criteria In Solid Tumors response to predict survival. Survival was estimated using the Kaplan–Meier method, compared using the log-rank test and Cox proportional hazards models, and stratified using matched pairs after propensity score matching.

Results

In total, 330 patients met the inclusion criteria (n = 92/group after propensity-score matching; median follow-up, 42 months). Five-year disease-free survival was 49% (95% confidence interval, 39-61) for neoadjuvant chemotherapy versus 48% (95% confidence interval, 38-61) for adjuvant chemotherapy (P = .70). On multivariable analysis, disease-free survival was not associated with neoadjuvant chemotherapy or adjuvant chemotherapy (hazard ratio, 1.1; 95% confidence interval, 0.64-1.90; P = .737), nor was overall survival (hazard ratio, 1.21; 95% confidence interval, 0.63-2.30; P = .572). The neoadjuvant chemotherapy group was more likely to receive full doses and cycles of chemotherapy (P = .014/0.005) and had fewer grade 3 or greater toxicities (P = .001). Response Evaluation Criteria In Solid Tumors response to neoadjuvant chemotherapy was associated with disease-free survival (P = .035); 15% of patients receiving neoadjuvant chemotherapy (14/92) had a major pathologic response.

Conclusions

Timing of chemotherapy, before or after surgery, is not associated with an improvement in overall or disease-free survival among patients with cT2-4N0-1M0 non–small cell lung cancer who undergo complete surgical resection.  相似文献   
177.
178.
179.
180.
Metabolism describes the series of chemical reactions that are concerned with the provision of energy to biological systems. They may be divided into reactions involved in energy yield (catabolism: demand exceeds supply), and energy storage (anabolism: supply exceeds demand). Regulation of these pathways is critical for homeostasis, and derangements in metabolism are seen in a wide variety of pathological processes. Understanding metabolism is key to the treatment of many diseases, notably diabetes, as well as underpinning clinical nutritional support.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号