全文获取类型
收费全文 | 251篇 |
免费 | 13篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 2篇 |
妇产科学 | 2篇 |
基础医学 | 32篇 |
临床医学 | 22篇 |
内科学 | 18篇 |
皮肤病学 | 1篇 |
神经病学 | 42篇 |
特种医学 | 9篇 |
外科学 | 87篇 |
综合类 | 2篇 |
预防医学 | 30篇 |
药学 | 13篇 |
肿瘤学 | 5篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 4篇 |
2020年 | 2篇 |
2019年 | 2篇 |
2018年 | 7篇 |
2017年 | 2篇 |
2016年 | 8篇 |
2015年 | 9篇 |
2014年 | 10篇 |
2013年 | 7篇 |
2012年 | 10篇 |
2011年 | 6篇 |
2010年 | 7篇 |
2009年 | 1篇 |
2008年 | 2篇 |
2007年 | 9篇 |
2006年 | 7篇 |
2005年 | 9篇 |
2004年 | 11篇 |
2003年 | 9篇 |
2002年 | 8篇 |
2001年 | 9篇 |
2000年 | 13篇 |
1999年 | 9篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1993年 | 3篇 |
1992年 | 11篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1989年 | 10篇 |
1988年 | 13篇 |
1987年 | 9篇 |
1986年 | 10篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 5篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1972年 | 2篇 |
1971年 | 2篇 |
排序方式: 共有265条查询结果,搜索用时 15 毫秒
261.
Alison Klasen Romain Kessari Lionel Mercier Cyril Valade Jacques Grill Romain Desmaris Angelo Paci 《Drugs in R&D》2014,14(1):13-23
In a context of day hospital care of cancer patients, a protocol combining etoposide and carboplatin is used in paediatrics. Disposable infusion devices can be used to improve patient quality of life and to optimize nursing time. Stability data are available for carboplatin in these devices but not for etoposide. The aim of this study was to determine the stability of etoposide solutions in these devices by monitoring the changing etoposide concentration. To study the changing etoposide concentration, we investigated three different concentrations, each in two different solvents: sodium chloride (NaCl) 0.9 % and dextrose 5 %, in Intermate® disposable infusion devices. Quantitative analyses were performed by high-performance liquid chromatography coupled with ultraviolet (UV) detection on samples collected over a 24-h study period. The results showed that 100 mg/L etoposide solutions were stable for 24 h in NaCl 0.9 % and for 12 h in dextrose 5 %, whatever the temperature. The 400-mg/L solutions were stable for 24 h in both diluents, whatever the temperature, whereas the 600-mg/L solutions when diluted in NaCl 0.9 % and dextrose 5 % in water were stable for 8 and 6 h, respectively. We found that precipitation was the main phenomenon responsible for decreased etoposide concentrations. This study allowed us to conclude that etoposide solutions prepared in Intermate® infusion devices are stable for day hospital administration in paediatrics. It will also allow us to conduct a future clinical study that will focus on the medico-economic feasibility of this protocol and on the evaluation of patient and nurse satisfaction. 相似文献
262.
A.-M.?LangenmaierEmail author E.?Metje B.?Klasen T.?Brinkschmidt M.?Karst V.?Amelung 《Schmerz (Berlin, Germany)》2018,32(6):456-463
Background
The subjective state of health with respect to pain and psyche was surveyed utilizing validated pain questionnaires in patients undergoing special pain therapy and represents the basis for targeted treatment measures.Objective
The purpose of this study was to investigate the possible distortion of answers due to social desirability of responses in chronic pain patients.Material and methods
During two survey periods assessing patient satisfaction using both anonymized and personalized questionnaires, the effects arising from socially desirable response patterns were analyzed. The sample consisted of chronic pain patients being treated in an inpatient therapy setting.Results
In both periods of observation no significant impact on the response behavior of chronic pain patients was found in personalized or anonymized questionnaires.Conclusion
The results of the study suggest that the responses of chronic pain patients with respect to their subjective state of health are not influenced by social desirability. Thus, scoring systems such as the German pain questionnaire will not be influenced by social desirability in chronic pain patients and can therefore be used as a part of diagnostics and therapy planning.263.
Klasen M Kenworthy CA Mathiak KA Kircher TT Mathiak K 《The Journal of neuroscience》2011,31(38):13635-13643
Supramodal representation of emotion and its neural substrates have recently attracted attention as a marker of social cognition. However, the question whether perceptual integration of facial and vocal emotions takes place in primary sensory areas, multimodal cortices, or in affective structures remains unanswered yet. Using novel computer-generated stimuli, we combined emotional faces and voices in congruent and incongruent ways and assessed functional brain data (fMRI) during an emotional classification task. Both congruent and incongruent audiovisual stimuli evoked larger responses in thalamus and superior temporal regions compared with unimodal conditions. Congruent emotions were characterized by activation in amygdala, insula, ventral posterior cingulate (vPCC), temporo-occipital, and auditory cortices; incongruent emotions activated a frontoparietal network and bilateral caudate nucleus, indicating a greater processing load in working memory and emotion-encoding areas. The vPCC alone exhibited differential reactions to congruency and incongruency for all emotion categories and can thus be considered a central structure for supramodal representation of complex emotional information. Moreover, the left amygdala reflected supramodal representation of happy stimuli. These findings document that emotional information does not merge at the perceptual audiovisual integration level in unimodal or multimodal areas, but in vPCC and amygdala. 相似文献
264.
265.
E. C. Klasen M. H. Hofker H. M. B. van Paassen M. Verlaan-de Vries J. L. Bos R. R. Frants 《Clinica chimica acta; international journal of clinical chemistry》1987,170(2-3):201-207
Oligonucleotide probes, specific for the two most common deficiency variants, Z and S, of alpha-1-antitrypsin have been successfully applied for the diagnosis at the DNA-level. The possible presence of silent alleles necessitates a careful study of the parents both at the protein- and DNA-level in prenatal diagnostic cases. 相似文献