全文获取类型
收费全文 | 63461篇 |
免费 | 4680篇 |
国内免费 | 333篇 |
专业分类
耳鼻咽喉 | 643篇 |
儿科学 | 1606篇 |
妇产科学 | 1543篇 |
基础医学 | 7845篇 |
口腔科学 | 1537篇 |
临床医学 | 6384篇 |
内科学 | 14402篇 |
皮肤病学 | 809篇 |
神经病学 | 5013篇 |
特种医学 | 1928篇 |
外国民族医学 | 2篇 |
外科学 | 9860篇 |
综合类 | 1016篇 |
现状与发展 | 1篇 |
一般理论 | 103篇 |
预防医学 | 5254篇 |
眼科学 | 1850篇 |
药学 | 4442篇 |
中国医学 | 139篇 |
肿瘤学 | 4097篇 |
出版年
2023年 | 269篇 |
2022年 | 386篇 |
2021年 | 1155篇 |
2020年 | 729篇 |
2019年 | 1012篇 |
2018年 | 1246篇 |
2017年 | 849篇 |
2016年 | 975篇 |
2015年 | 1138篇 |
2014年 | 1779篇 |
2013年 | 2816篇 |
2012年 | 3782篇 |
2011年 | 4127篇 |
2010年 | 2349篇 |
2009年 | 2196篇 |
2008年 | 4016篇 |
2007年 | 4212篇 |
2006年 | 4041篇 |
2005年 | 4121篇 |
2004年 | 3848篇 |
2003年 | 3460篇 |
2002年 | 3429篇 |
2001年 | 741篇 |
2000年 | 634篇 |
1999年 | 724篇 |
1998年 | 741篇 |
1997年 | 611篇 |
1996年 | 494篇 |
1995年 | 493篇 |
1994年 | 466篇 |
1993年 | 442篇 |
1992年 | 544篇 |
1991年 | 521篇 |
1990年 | 422篇 |
1989年 | 443篇 |
1988年 | 402篇 |
1987年 | 378篇 |
1986年 | 360篇 |
1985年 | 426篇 |
1984年 | 439篇 |
1983年 | 397篇 |
1982年 | 533篇 |
1981年 | 448篇 |
1980年 | 493篇 |
1979年 | 308篇 |
1978年 | 333篇 |
1977年 | 330篇 |
1976年 | 272篇 |
1975年 | 296篇 |
1974年 | 254篇 |
排序方式: 共有10000条查询结果,搜索用时 671 毫秒
251.
Marika A. Artz Johannes M. M. Boots Gerry Ligtenberg Joke I. Roodnat Maarten H. L. Christiaans Pieter F. Vos Philip Moons George Borm Luuk B. Hilbrands 《American journal of transplantation》2004,4(6):937-945
Long-term use of cyclosporine after renal transplantation results in nephrotoxicity and an increased cardiovascular risk profile. Tacrolimus may be more favorable in this respect. In this randomized controlled study in 124 renal transplant patients, the effects of conversion from cyclosporine to tacrolimus on renal function, cardiovascular risk factors, and perceived side-effects were investigated after a follow-up of 2 years. After conversion from cyclosporine to tacrolimus renal function remained stable, whereas continuation of cyclosporine was accompanied by a rise in serum creatinine from 142 +/- 48 micromol/L to 157 +/- 62 micromol/L (p < 0.05 comparing both groups). Conversion to tacrolimus resulted in a sustained reduction in systolic and diastolic blood pressure, and a sustained improvement in the serum lipid profile, leading to a reduction in the Framingham risk score from 5.7 +/- 4.3 to 4.8 +/- 5.3 (p < 0.05). Finally, conversion to tacrolimus resulted in decreased scores for occurrence of and distress due to side-effects. In conclusion, conversion from cyclosporine to tacrolimus in stable renal transplant patients is beneficial with respect to renal function, cardiovascular risk profile, and side-effects. Therefore, for most renal transplant patients tacrolimus will be the drug of choice when long-term treatment with a calcineurin inhibitor is indicated. 相似文献
252.
Pelvic floor muscle training with biofeedback and bladder training in elderly women: a feasibility study. 总被引:1,自引:0,他引:1
Louise Perrin Sharon Wood Dauphinée Jacques Corcos James A Hanley George A Kuchel 《Journal of wound, ostomy, and continence nursing》2005,32(3):186-199
OBJECTIVE: It is generally assumed that interventions used to treat urinary incontinence (UI) in young women could simply be applied to older competent and motivated women, but these assumptions have not been formally tested. The purpose of this study was to determine the feasibility of using physical therapies to treat UI in older women. DESIGN: Twelve-week time series. SETTINGS AND SUBJECTS: We recruited women older than 75 years with UI from an outpatient urology clinic and a waiting list for incontinence surgery. METHODS: After a baseline evaluation, the women collected data on their incontinence symptoms and bladder habits for 3 weeks using the 72-hour voiding diary and the 24-hour pad test. They then received 6 physical therapy treatments consisting of a combination of bladder training and pelvic floor muscle training assisted with biofeedback for 6 weeks. This was followed by another 3-week period of data collection and a final evaluation. RESULTS: Ten women participated in the study; 7 completed it. They were all comfortable with the treatment. They complied with the study demands in terms of attendance at treatment session (100%), data collection (96%), and completion of exercises at home (82%). The authors observed a decrease in the number of incontinent and urgency episodes. CONCLUSION: This preliminary study demonstrates that some women older than 75 years are good candidates to undertake physical therapies for UI and follow study demands. Random controlled studies that include this population will provide evidence regarding the effectiveness of these therapies. 相似文献
253.
254.
Dr. Steven A. Curley MD Robert A. Newman PhD Thomas B. Dougherty MD PhD George M. Fuhrman MD Diana L. Stone BS Jeffrey A. Mikolajek CRNA Sal Guercio CCP Ann Guercio CCP C. Humberto Carrasco MD M. Tien Kuo PhD David C. Hohn MD 《Annals of surgical oncology》1994,1(5):389-399
Background: We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in
patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could
be limited after high-dose hepatic arterial infusion (HAI), and (b) the hepatic maximum tolerated dose (MTD) of doxorubicin.
Methods: Ten patients with biopsy-proven HCC were treated with 20-min HAI of doxorubicin (17 total treatments). Two patients were
treated with doxorubicin 60 mg/m2, three patients were treated at 90 mg/m2, and five patients received 120 mg/m2. A newly developed dual-balloon vena cava catheter was advanced from the femoral vein, and the balloons were inflated to
isolate and capture total hepatic venous outflow. The hepatic venous blood was pumped through extracorporeal carbon chemofilters
before return of the blood to the systemic circulation.
Results: Peak systemic doxorubicin levels were an average 85.6% lower than were peak prefilter levels (p<0.01). Because all catheters
were placed percutaneously and because the chemofiltration markedly limited systemic chemotherapy exposure, patients were
discharged 1 day after 16 of the 17 treatments. The hepatic and systemic MTD of doxorubicin in this treatment protocol was
120 mg/m2.
Conclusions: This novel system of complete hepatic venous isolation and chemofiltration limits systemic chemotherapy toxicity and will
allow use of higher doses of chemotherapeutic agents to treat HCC.
The results of this study were presented at the 46th Annual Cancer Symposium of The Society of Surgical Oncology, Los Angeles,
California, March 18–21, 1993. 相似文献
255.
George M. Smith H.David Shine 《International journal of developmental neuroscience》1992,10(5):387-392
Tight junctions may play an important role in maintaining the integrity of the blood-brain barrier. These junctions can be individually visualized using electron microscopy but no current technique is able to provide a more global picture of the presence and density of tight junctions in central nervous system tissue. We used an antibody that recognizes a high molecular weight protein (ZO-1) associated with tight junctions, to identify these specialized junctions within the rat brain and spinal cord. Immunofluorescent labeling showed a network of tight junctions between cells in the brain vasculature, leptomeninges and choroid plexus, and between tanycytes lining the floor of the third ventricle and the central canal of the spinal cord. Anti-ZO-1 labeled the majority of cells associated with the blood-brain barrier and may prove a useful marker, possibly in conjunction with functional dye studies, in evaluating the anatomical and functional integrity of the blood-brain barrier. 相似文献
256.
257.
Pierre man John Gordon Hkan Mellstedt Peter Biberfeld George Klein 《European journal of haematology》1988,40(2):142-148
Leukemic cells from a series of patients with chronic B-lymphocytic leukemia (CLL) were analyzed for their buoyant density on discontinuous Percoll gradients. The density profile varied markedly between different patients and also between samples from different body compartments within the same patient. A good correlation was observed between buoyant density and maturation stage of the leukemic clones as judged by Ig-expression and their reactivity with a panel of monoclonal antibodies. Phorbol-ester-induced changes in the leukemic cells were found to be accompanied by a general decrease in their buoyant density. No correlation between density and clinical parameters such as cell counts, clinical stage and survival could be noted. Buoyant density characterization of leukemic B-cell populations is seen as a useful, rapid and simple marker of compartmentalization within the B-lymphocyte maturation spectrum but its clinical relevance remains to be established. 相似文献
258.
259.
The presence of class 1 and class 2 histocompatibility antigens on murine sperm was investigated by flow microfluorometry. Monoclonal anti-H-2Kk (class 1), anti-Iak (specificity 2, class 2) and allo-anti-Iak (class 2) antisera were used in direct or indirect fluorescence labelling experiments to probe the expression of class 1 and class 2 antigens on epididymal mouse spermatozoa. Sperm-specific antibodies were generated by intraperitoneal immunization of both male and female C3H/HeN mice with syngeneic spermatozoa. Sperm-specific antigens were detected in 68-85% of syngeneic mouse sperm and 65-90% of allogeneic mouse sperm examined. Conversely, these antibodies did not stain syngeneic or allogeneic lymphocytes above the background of the negative control. Mouse sperm samples failed to exhibit specific fluorescence above the background of negative control values with antibodies against either class 1 or class 2 MHC antigens. We have established the sensitive, objective and economical assay of sperm membrane antigens with fluorochrome-labelled antibodies by flow microfluorometry. By use of this sensitive and objective technique we have not detected MHC antigens on murine sperm. We conclude that these MHC antigens are not expressed on sperm at a level to be practically detectable. 相似文献
260.
Homicide inflicts massive injury upon the intrapsychic and interpersonal realities of the surviving kin of murder victims. A New York City pilot program of outreach and counselling to 1182 families of Brooklyn homicide victims suggests that surviving kin undergo the symptoms of traumatic stress disorder. Recovery is prolonged by knowledge that the perpetrator is usually alive and in some cases unpunished, by repetitive confrontations with the criminal justice system and by the multiple losses endured: loss of a family member, loss of illusions of safety and invulnerability, loss of a sense of trust in the surrounding community, and loss of a belief system. Effective help to survivors requires interventions that respond to all aspects of the survivors' losses. 相似文献