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51.
As many as two-thirds of multiple sclerosis (MS) patients are unable to retain employment. Neurological and cognitive status
are known to be significant predictors of unemployment, but the relationship between the two is unclear. Furthermore, the
association between employment status and depression, anxiety, and personality has not been adequately explored in MS patients.
This study examined the demographic, neurological, neuropsychological, and personality factors associated with unemployment
in MS. We also sought to determine the utility of the Multiple Sclerosis Functional Composite (MSFC), a measure of MS-related
disability incorporating physical and cognitive measures, in predicting employment status. A consecutive sample of 106 MS
patients (61.3% unemployed) completed the Brief Repeatable Battery of Neuropsychological Tests (BRBN), Hospital Anxiety and
Depression Scale (HADS), and NEO Five-Factor Personality Inventory. The MSFC emerged as the most robust predictor of employment
status in MS patients, exceeding the predictive value of the EDSS. Together with NEO “Agreeableness” and HADS Depression subscore,
the MSFC accounted for 49.8% of the variance in employment status. Unemployment was also associated with a progressive disease
course, longer disease duration, and being female. While Global Cognitive Impairment did not differentiate between groups,
unemployed patients scored significantly lower on three of five BRBN indices: Symbol Digit Modality Test, Paced Auditory Serial
Addition Test, and Word List Generation. The findings highlight the utility of the MSFC as a predictor of unemployment in
MS. Furthermore, a strong association was found between unemployment and the personality construct “Agreeableness”, and severity
of depression. 相似文献
52.
Norouzi V Azizi H Fattahi Z Esteghamat F Bazazzadegan N Nishimura C Nikzat N Jalalvand K Kahrizi K Smith RJ Najmabadi H 《American journal of medical genetics. Part A》2011,(10):2453-2458
Mutations in GJB2 are a major cause of autosomal recessive non-syndromic hearing loss (ARNSHL) in many populations. A single mutation of this gene (35delG) accounts for approximately 70% of GJB2 mutations that are associated with ARNSHL in Caucasians in many European countries and also in Iranian. In this study, we used PCR and restriction digestion to genotype five single nucleotide polymorphisms (SNPs) that define the genetic background of the 35delG mutation over an interval of 98 Kbp that includes the coding and flanking regions of GJB2. Two microsatellite markers, D13S175 and D13S141, were also analyzed in patients and controls. These data suggest that the 35delG mutation originated in northern Iran. 相似文献
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Nuri Kaydıhan Kimia Çepni Şefika Arzu Ergen Mustafa Şükrü Şenocak Didem Çolpan Öksüz 《Japanese journal of radiology》2017,35(12):733-739
Purpose
Our objective was to analyze kidney damage using glomerular filtration rate (GFR) and dynamic renal scintigraphy (DRS) compared with dose volume histogram (DVH) parameters in gastric cancer patients.Materials and methods
Twenty-two gastric cancer patients treated with postoperative chemoradiotherapy were retrospectively evaluated. Student’s t test was used to compare pre- and posttreatment GFR and creatinine values. The relative contribution of the left and right kidney in DRS results was expressed as left-to-right ratio (L/R), and the percentage of initial and control participation ratio difference was calculated. Spearman’s correlation analysis was used to compare the percentage difference of L/R ratio with DVH parameters of each kidney.Results
In DRS analysis, decrease in left kidney cortical function was observed in one patient. V5–V10 of the left and bilateral kidneys were significantly associated with GFR decline. None of the DVH parameter was significantly associated with L/R ratio. However, the V15 and Dmean of the bilateral kidney were significantly correlated with greater decrease in L/R ratio in seven patients whose posttreatment DRS period was > 12 months.Conclusions
Decline in renal function, even with current renal constraints, was observed. Minimization of V5, V10, and V15 and mean dose (Dmean) to the kidney should be considered.57.
Tony Liu Wei Liu Aaron Leung Sangyang Jia Patsy Lee Luke Liu Adam Mutsaers Sue Miller Kimia Honarmand Shiraz Malik Melody Qu Ian Ball 《Current oncology (Toronto, Ont.)》2022,29(12):9407
Background: Medical assistance in dying (MAID) was legislatively enacted in Canada in June 2016. Most studies of patients who received MAID grouped patients with cancer and non-cancer diagnoses. Our goal was to analyze the characteristics of oncology patients who received MAID in a Canadian tertiary care hospital. Methods: We conducted a retrospective review of all patients with cancer who received MAID between June 2016 and July 2020 at London Health Sciences Centre (LHSC). We describe patients’ demographics, oncologic characteristics, symptoms, treatments, and palliative care involvement. Results: Ninety-two oncology patients received MAID. The median age was 72. The leading cancer diagnoses among these patients were lung, colorectal, and pancreatic. At the time of MAID request, 68% of patients had metastatic disease. Most patients (90%) had ECOG performance status of 3 or 4 before receiving MAID. Ninety-nine percent of patients had distressing symptoms at time of MAID request, most commonly pain. One-third of patients with metastatic or recurrent cancer received early palliative care. The median time interval between the first MAID assessment and receipt of MAID was 7 days. Interpretation: Most oncology patients who received MAID at LHSC had poor performance status and almost all had distressing symptoms. The median time interval between first MAID assessment and receipt of MAID was shorter than expected. Only one-third of patients with metastatic or recurrent cancer received early palliative care. Improving access to early palliative care is a priority in patients with advanced cancer. Study registration: We received research approval from Western University’s Research Ethics Board (REB) with project ID number 115367, and from Lawson’s Research Database Application (ReDA) with study ID number 9579. 相似文献
58.
Mohsen Pourazizi Bahram Eshraghi Roya Azad Kimia Afshar Iman Mohammadbeigy 《Clinical Case Reports》2022,10(9)
In this report, a father with a history of diabetes mellitus and his son without a remarkable past medical history, both got COVID‐19‐ associated mucormycosis (CAM) as evidenced by their clinical and radiological findings. This suggests the possible role of genetics in combination with the environment in susceptibility to CAM. 相似文献
59.
Streptococcus‐related acute suppurative thyroiditis in a COVID‐19‐positive child: A rare case report
Elham Maleki Kimia Iranmanesh Mohammad Javad Najafzadeh Amir Baniasad 《Clinical Case Reports》2023,11(1)
In this case report, we present a 10‐year‐old girl with acute suppurative thyroiditis (AST) symptoms, such as fever, sore throat, and swelling in the suprasternal region, who had a positive PCR test for COVID‐19. The result of the secretions culture obtained from the abscess drainage was positive for nonhemolytic Streptococcus. 相似文献
60.