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951.
Congenital factor V deficiency is an uncommon bleeding disorder that necessitates hemostatic correction before surgery. We herein describe a patient with severe factor V deficiency who underwent successful off-pump coronary artery bypass grafting with a transfusion of fresh-frozen plasma. 相似文献
952.
Ohki K Yamamoto Y Matsukawa T Gouhara T Matsuzaki Y Oshibuchi T 《Masui. The Japanese journal of anesthesiology》2003,52(5):542-546
BACKGROUND: The measurement of infusion fluid temperature is important for patients' thermoregulatory management. However, we usually estimate the temperature by touching and feeling the surface of the infusion bag. Accordingly, there is increasing demand for more quantitative method to measure infusion fluid temperature. METHODS: In the operating room we evaluated the accuracy and precision of the infrared thermometer (Genius) for the measurement of infusion fluid temperature compared with the thermistor. RESULTS: The fluid temperature measured by Genius is accurate with sufficient precision compared with that measured by thermistor. CONCLUSIONS: The temperature measurement of infusion fluid by infrared thermometer is clinically helpful and useful for patients' safety. 相似文献
953.
Nobuhiro Koyanagi Kiyoshi Inokuchi Kazushige Beppu Kenji Nagamine Makoto Hashizume Keizo Sugimachi 《Surgery today》1985,15(2):134-139
The time of appearance of the left gastric vein on serial celiac arteriograms in patients with portal hypertension and esophageal
varices was compared with that of the portal vein to assess regional hemodynamics in the left venous portion of the stomach,
an area located in close proximity to the varices. In two thirds of all the patients with cirrhosis or non-cirrhotic idiopathic
portal hypertension (IPH), the left gastric vein was visualized earlier or simultaneously than or with the portal vein, while
in all but one patient with prehepatic portal obstruction, there was a delayed opacification of the left gastric vein. These
results suggest the presence of a hyperdynamic circulatory state which promotes venous hypertension in the left gastric venous
area of the stomach of a considerable number of patients with cirrhosis or IPH. In such a hemodynamic state, selective decompression
of varices can be achieved by a left gastric venous caval shunt. 相似文献
954.
Management of pancreatic mass accompanying chronic pancreatitis 总被引:1,自引:0,他引:1
Yoshioka M Shibata S Sato T Furuya T Asanuma Y Hashimoto M Koyama K 《Journal of Hepato-Biliary-Pancreatic Surgery》2002,9(3):376-378
We report two patients with focal, chronic pancreatitis that was diagnosed by dynamic computed tomography (CT) combined with
intraoperative biopsy. In case 1, serum carbohydrate antigen (CA) 19-9 level rose to 160 U/ml. Abdominal ultrasonography,
CT, and magnetic resonance imaging demonstrated a mass, of 4.5 cm in diameter, in the pancreatic head. On dynamic CT, the
mass was enhanced similarly to the normal pancreatic parenchyma. In case 2, dynamic CT demonstrated a mass, of 3.0 cm in diameter,
in the pancreatic head, which was enhanced similarly to the normal pancreatic parenchyma. From such characteristics of enhancement,
both masses were suspected to be chronic pancreatitis rather than cancer, and the diagnosis was confirmed by intraoperative
biopsy. Three years in case 1 and 2 years in case 2 have passed since their operations, and the size of each mass has not
changed. With the use of dynamic CT combined with intraoperative biopsy, focal chronic pancreatitis could be diagnosed more
accurately, and this may lead to a reduction in unnecessary pancreatic resection.
Received: November 16, 2001 / Accepted: February 8, 2002 相似文献
955.
An autopsy case of Balamuthia mandrillaris amoebic encephalitis,a rare emerging infectious disease,with a brief review of the cases reported in Japan 下载免费PDF全文
Kyoko Itoh Kenji Yagita Tomoyoshi Nozaki Harutaka Katano Hideki Hasegawa Koushun Matsuo Youhei Hosokawa So Tando Shinji Fushiki 《Neuropathology》2015,35(1):64-69
Balamuthia mandrillaris is an amoeba found in fresh water and soil that causes granulomatous amoebic encephalitis. We report herein an autopsy case of B. mandrillaris amoebic encephalitis, which was definitely diagnosed by PCR. An 81‐year‐old man, who had Sjögren's syndrome, manifested drowsiness 2 months before his death with progressive deterioration. Neuroimaging demonstrated foci of T2‐ and fluid‐attenuated inversion recovery high and T1 low‐intensity with irregular post‐contrast ring enhancement in the cerebral hemisphere, thalamus and midbrain. Pathologically, multiple hemorrhagic and necrotic lesions were found in the cerebrum, thalamus, midbrain, pons, medulla and cerebellum, which were characterized by liquefactive necrosis, marked edema, hemorrhage and necrotizing vasculitis associated with the perivascular accumulation of amoebic trophozoites, a few cysts, and the infiltration of numerous neutrophils and microglia/macrophages. The trophozoites were ovoid or round, 10–60 μm in diameter, and they showed foamy cytoplasm and a round nucleus with small karyosome in the center. The PCR and immunohistochemistry from paraffin‐embedded brain specimens revealed angioinvasive encephalitis due to B. mandrillaris. Human cases of B. mandrillaris brain infection are rare in Japan, with only a few brief reports in the literature. 相似文献
956.
Okugawa G Nobuhara K Minami T Tamagaki C Takase K Sugimoto T Sawada S Kinoshita T 《Neuropsychobiology》2004,50(2):119-123
Diffusion tensor imaging (DTI) was used to investigate subtle disruption in the middle cerebellar peduncles in patients with schizophrenia. Fractional anisotropy (FA) was measured in 25 patients with schizophrenia and 21 healthy subjects using DTI. The FA of the right and left middle cerebellar peduncles was significantly lower in the schizophrenic patients compared to healthy subjects. FA in the left middle cerebellar peduncles was significantly correlated with the dosage of neuroleptics in patients with schizophrenia. There were no significant differences of mean diffusivity in the right and left middle cerebellar peduncles between patients with schizophrenia and healthy subjects. The findings of the study suggest that antipsychotics may improve the subtle disruption in the middle cerebellar peduncles in patients with schizophrenia. 相似文献
957.
Antithrombin reduces the ischemia/reperfusion-induced spinal cord injury in rats by attenuating inflammatory responses 总被引:5,自引:0,他引:5
Hirose K Okajima K Uchiba M Nakano KY Utoh J Kitamura N 《Thrombosis and haemostasis》2004,91(1):162-170
Antithrombin (AT) reveals its antiinflammatory activity by promoting endothelial release of prostacyclin (PGI(2)) in vivo. Since neuroinflammation is critically involved in the development of ischemia/reperfusion (I/R)-induced spinal cord injury (SCI), it is possible that AT reduces the I/R-induced SCI by attenuating the inflammatory responses. We examined this possibility using rat model of I/R-induced SCI in the present study. AT significantly reduced the mortality and motor disturbances by inhibiting reduction of the number of motor neurons in animals subjected to SCI. Microinfarctions of the spinal cord seen after reperfusion were markedly reduced by AT. AT significantly enhanced the I/R-induced increases in spinal cord tissue levels of 6-keto-PGFIalpha, a stable metabolite of PGI2. AT significantly inhibited the I/R-induced increases in spinal cord tissue levels of TNF-alpha, rat interleukin-8 and myeloperoxidase. In contrast,Trp(49) -modified AT did not show any protective effects. Pretreatment with indomethacin significantly reversed the protective effects of AT. An inactive derivative of factor Xa, which selectively inhibits thrombin generation, has been shown to fail to reduce SCI.Taken together, these observations strongly suggested that AT might reduce I/R-induced SCI mainly by the antiinflammatory effect through promotion of endothelial production of PGI(2). These findings also suggested that AT might be a potential neuroprotective agent. 相似文献
958.
Quantitative analysis of the spinal cord motoneuron under chronic compression: an experimental observation in the mouse 总被引:5,自引:0,他引:5
Hisatoshi Baba Yasuhisa Maezawa Shinichi Imura Norio Kawahara Kenji Nakahashi Katsuro Tomita 《Journal of neurology》1996,243(2):109-116
We investigated quantitative changes in spinal cord motoneurons following chronic compression using a mouse model of cervical
cord compression. Twenty-five tiptoe-walking Yoshimura (twy) mice with calcified mass lesions compressing the spinal cord
posterolaterally at the C1–C2 vertebral levels were compared with five Institute of Cancer Research (ICR) mice that served
as controls. Spinal cord motoneurons in the anterior grey horn between the C1 and C3 spinal cord segments were Nissl-stained
and counted topographically and then analysed in relation to the extent of spinal cord compression. The number of motoneurons
in C1–C3 spinal cord segments decreased significantly with a linear correlation with the transverse area of the spinal cord
when the cord was compressed to 50–70% of control values. A significant reduction in the number of motoneurons occurred at
the C2–C3 spinal cord segment compressed at the C1–C2 vertebral level. In contrast, at the level rostral to the C1 vertebra,
the number of motoneurons increased significantly in proportion to the magnitude of compression. The current study demonstrates
that a number of neurons, morphologically consistent with anterior horn cells, were observed at a rostral site absolutely
free of external compression where no such cells normally exist. 相似文献
959.
Katsuaki Suzuki Kenji Hashimoto Yasuhide Iwata Kazuhiko Nakamura Masatsugu Tsujii Kenji J Tsuchiya Yoshimoto Sekine Shiro Suda Genichi Sugihara Hideo Matsuzaki Toshiro Sugiyama Masayoshi Kawai Yoshio Minabe Nori Takei Norio Mori 《Neuropsychopharmacology》2007,62(3):267-269
BACKGROUND: The neurobiological basis for autism remains poorly understood. Given the role of growth factors in brain development, we hypothesized that epidermal growth factor (EGF) may play a role in the pathophysiology of autism. In this study, we examined whether serum levels of EGF are altered in adult subjects with high-functioning autism. METHODS: We measured serum levels of EGF in the 17 male subjects with high-functioning autism and 18 age-matched healthy male subjects. RESULTS: The serum levels of EGF in the subjects with high-functioning autism (72.4 +/- 102.8 pg/mL [mean +/- SD]) were significantly lower (Mann-Whitney U = 22.0, p < .001) than those of normal control subjects (322.3 +/- 122.0 pg/mL [mean +/- SD]). However, there were no correlations between serum EGF levels and clinical variables in the subjects with autism. CONCLUSIONS: This study suggests that decreased levels of EGF might be implicated in the pathophysiology of high-functioning autism. 相似文献
960.