全文获取类型
收费全文 | 52608篇 |
免费 | 3942篇 |
国内免费 | 176篇 |
专业分类
耳鼻咽喉 | 544篇 |
儿科学 | 1715篇 |
妇产科学 | 1087篇 |
基础医学 | 7285篇 |
口腔科学 | 1483篇 |
临床医学 | 5684篇 |
内科学 | 10463篇 |
皮肤病学 | 1182篇 |
神经病学 | 4932篇 |
特种医学 | 1335篇 |
外国民族医学 | 1篇 |
外科学 | 6172篇 |
综合类 | 676篇 |
一般理论 | 33篇 |
预防医学 | 5746篇 |
眼科学 | 906篇 |
药学 | 3729篇 |
中国医学 | 160篇 |
肿瘤学 | 3593篇 |
出版年
2023年 | 491篇 |
2022年 | 931篇 |
2021年 | 1813篇 |
2020年 | 1043篇 |
2019年 | 1572篇 |
2018年 | 1801篇 |
2017年 | 1264篇 |
2016年 | 1371篇 |
2015年 | 1513篇 |
2014年 | 2048篇 |
2013年 | 2733篇 |
2012年 | 4085篇 |
2011年 | 4229篇 |
2010年 | 2276篇 |
2009年 | 1933篇 |
2008年 | 3204篇 |
2007年 | 3148篇 |
2006年 | 2943篇 |
2005年 | 2806篇 |
2004年 | 2482篇 |
2003年 | 2234篇 |
2002年 | 2064篇 |
2001年 | 752篇 |
2000年 | 643篇 |
1999年 | 583篇 |
1998年 | 365篇 |
1997年 | 303篇 |
1996年 | 321篇 |
1995年 | 242篇 |
1994年 | 229篇 |
1993年 | 204篇 |
1992年 | 395篇 |
1991年 | 388篇 |
1990年 | 402篇 |
1989年 | 357篇 |
1988年 | 290篇 |
1987年 | 295篇 |
1986年 | 240篇 |
1985年 | 264篇 |
1984年 | 233篇 |
1983年 | 171篇 |
1982年 | 154篇 |
1981年 | 116篇 |
1980年 | 122篇 |
1979年 | 175篇 |
1978年 | 147篇 |
1977年 | 113篇 |
1976年 | 101篇 |
1974年 | 130篇 |
1973年 | 111篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
Christina A. White Marshall R. Jones Melanie K. Kuester Kelly L. Myers Barbara A. Schnarr 《Hospital pharmacy》2015,50(5):370-375
Purpose:
To establish a cost-effective centralized pharmacy call center to serve the patients of Veterans Integrated Service Network (VISN) 11 that would meet established performance metrics.Methods:
A pilot project began in August 2011 with the Indianapolis VA Medical Center (VAMC) and the Health Resource Center (HRC) in Topeka, Kansas. The Indianapolis VAMC used a first-call resolution business model consisting of pharmacy technicians receiving tier 1 phone calls that could be escalated to a tier 2 line that consisted of lead technicians and pharmacists, while the HRC utilized general telephone agents that would transfer unresolved calls to the primary facility. Pre- and post-VISN 11 Pharmacy Call Center performance metrics were compared for each of the 7 facilities in the network with the goals being monthly average abandoned call rate less than 5% and average speed to answer less than 30 seconds. Cost per call was also compared.Results:
The average abandoned call rate for the network during the year prior to VISN 11 Pharmacy Call Center implementation (August 2010-July 2011) was 15.66% and decreased to 3% in July 2014. The average abandoned call rate decreased for each individual facility. In fiscal year 2014, the VISN 11 Pharmacy Call Center was operating at a cost of $4.35 per call while providing more services than the HRC, resulting in less workload being transferred back to the individual facilities.Conclusion:
A centralized VISN pharmacy call center is a reasonable alternative to individual facility call centers or the HRC. 相似文献992.
R B Laprairie A M Bagher M E M Kelly E M Denovan‐Wright 《British journal of pharmacology》2015,172(20):4790-4805
Background and Purpose
Cannabidiol has been reported to act as an antagonist at cannabinoid CB1 receptors. We hypothesized that cannabidiol would inhibit cannabinoid agonist activity through negative allosteric modulation of CB1 receptors.Experimental Approach
Internalization of CB1 receptors, arrestin2 recruitment, and PLCβ3 and ERK1/2 phosphorylation, were quantified in HEK 293A cells heterologously expressing CB1 receptors and in the STHdh Q7/Q7 cell model of striatal neurons endogenously expressing CB1 receptors. Cells were treated with 2‐arachidonylglycerol or Δ9‐tetrahydrocannabinol alone and in combination with different concentrations of cannabidiol.Key Results
Cannabidiol reduced the efficacy and potency of 2‐arachidonylglycerol and Δ9‐tetrahydrocannabinol on PLCβ3‐ and ERK1/2‐dependent signalling in cells heterologously (HEK 293A) or endogenously (STHdh Q7/Q7) expressing CB1 receptors. By reducing arrestin2 recruitment to CB1 receptors, cannabidiol treatment prevented internalization of these receptors. The allosteric activity of cannabidiol depended upon polar residues being present at positions 98 and 107 in the extracellular amino terminus of the CB1 receptor.Conclusions and Implications
Cannabidiol behaved as a non‐competitive negative allosteric modulator of CB1 receptors. Allosteric modulation, in conjunction with effects not mediated by CB1 receptors, may explain the in vivo effects of cannabidiol. Allosteric modulators of CB1 receptors have the potential to treat CNS and peripheral disorders while avoiding the adverse effects associated with orthosteric agonism or antagonism of these receptors.Abbreviations
- 2‐AG
- 2‐arachidonyl glycerol
- BRETEff
- BRET efficiency
- CBD
- cannabidiol
- FAAH
- fatty acid amide hydrolase
- NAM
- negative allosteric modulator
- THC
- Δ9‐tetrahydrocannabinol
993.
994.
995.
996.
997.
998.
Elsa Balleydier Guillaume Camuset Cristina Socolovschi Marie-Pierre Moiton Barbara Kuli Aurélie Foucher Patrice Poubeau Gianandrea Borgherini Guillaume Wartel Héla Audin Didier Raoult Laurent Filleul Philippe Parola Fréderic Pagès 《Emerging infectious diseases》2015,21(2):316-319
Murine typhus case was initially identified in Reunion, France, in 2012 in a tourist. Our investigation confirmed 8 autochthonous cases that occurred during January 2011–January 2013 in Reunion. Murine typhus should be considered in local patients and in travelers returning from Reunion who have fevers of unknown origin. 相似文献
999.
Anthony Fok Cristina Mateevici Belinda Lin Ronil V. Chandra Victor H.T. Chong 《Emerging infectious diseases》2015,21(11):2074-2076
Human metapneumovirus pneumonia, most commonly found in children, was diagnosed in an adult with encephalitis. This case suggests that testing for human metapneumovirus RNA in nasopharyngeal aspirate and cerebrospinal fluid samples should be considered in adults with encephalitis who have a preceding respiratory infection, 相似文献
1000.
There is an increasing expectation that children, young people and their parents should participate in decisions that affect them. This includes decisions about their health and social care and collective or public decisions about the way in which such services are designed, delivered and evaluated. Indeed this has become a policy priority across the United Kingdom. The participation of disabled children and young people, however, has been slow to develop in the United Kingdom and concerns have been expressed about progress in this area. Drawing on the results of an Economic and Social Research Council-funded, mixed-methods study, the aim of this article is to explore the participation of disabled children and young people through a social justice lens. Participants, recruited by purposeful sampling, included 18 disabled children and young people, 77 parents and 90 professionals from one health and social care trust in Northern Ireland. There were four phases of data collection: surveys to parents and professionals, parent interviews, interviews with children and young people using creative and participatory techniques, and a focus group with professionals. Results showed that for most disabled children and young people, decision-making was firmly grounded in a family-centred model. However, when children and young people were drawn into participatory processes by adults and recognised as partners in interactions with professionals, they wanted more say and were more confident about expressing their views. Choices, information and resources were at times limited and this had a key impact on participation and the lives of these children, young people and their parents. The article concludes by exploring implications for further research and practice. The need for a two-pronged, social justice approach is recommended as a mechanism to advance the participation agenda. 相似文献