全文获取类型
收费全文 | 2542篇 |
免费 | 139篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 29篇 |
妇产科学 | 26篇 |
基础医学 | 273篇 |
口腔科学 | 154篇 |
临床医学 | 130篇 |
内科学 | 661篇 |
皮肤病学 | 32篇 |
神经病学 | 190篇 |
特种医学 | 89篇 |
外科学 | 468篇 |
综合类 | 10篇 |
预防医学 | 32篇 |
眼科学 | 18篇 |
药学 | 224篇 |
中国医学 | 3篇 |
肿瘤学 | 331篇 |
出版年
2023年 | 13篇 |
2022年 | 38篇 |
2021年 | 47篇 |
2020年 | 29篇 |
2019年 | 45篇 |
2018年 | 71篇 |
2017年 | 55篇 |
2016年 | 62篇 |
2015年 | 52篇 |
2014年 | 85篇 |
2013年 | 87篇 |
2012年 | 127篇 |
2011年 | 159篇 |
2010年 | 96篇 |
2009年 | 80篇 |
2008年 | 134篇 |
2007年 | 137篇 |
2006年 | 159篇 |
2005年 | 129篇 |
2004年 | 106篇 |
2003年 | 138篇 |
2002年 | 140篇 |
2001年 | 94篇 |
2000年 | 77篇 |
1999年 | 73篇 |
1998年 | 36篇 |
1997年 | 27篇 |
1996年 | 20篇 |
1995年 | 26篇 |
1994年 | 13篇 |
1993年 | 25篇 |
1992年 | 35篇 |
1991年 | 28篇 |
1990年 | 35篇 |
1989年 | 31篇 |
1988年 | 15篇 |
1987年 | 19篇 |
1986年 | 22篇 |
1985年 | 18篇 |
1984年 | 9篇 |
1983年 | 12篇 |
1982年 | 17篇 |
1981年 | 6篇 |
1980年 | 8篇 |
1979年 | 14篇 |
1978年 | 14篇 |
1977年 | 5篇 |
1971年 | 4篇 |
1969年 | 6篇 |
1968年 | 4篇 |
排序方式: 共有2700条查询结果,搜索用时 11 毫秒
61.
Oyama K Tsujimoto A Otsuka E Shimizu Y Shiratsuchi K Tsubota K Takamizawa T Miyazaki M 《Dental materials journal》2012,31(1):26-31
We compared the surface free energies and enamel bond strengths of single-step self-etch adhesives with and without an oxygen-inhibited layer. The adhesives were applied to the enamel surfaces of bovine incisors, light irradiated, and the oxygen-inhibited layer was either retained or removed with ethanol. The surface free energies and their components (γ(S)(LW), γ(S)(+), and γ(S)(-)) were determined by measuring the contact angles of three test liquids placed on the cured adhesives. The enamel bond strengths of specimens with and without the oxygen-inhibited layer were measured. For all surfaces, the value of the estimated surface tension component γ(S)(LW) was relatively constant. The value of the γ(S)(+) component increased slightly when the oxygen-inhibited layer was removed, whereas that of the γ(S)(-) component decreased significantly. The enamel bond strengths of the self-etch adhesives were significantly lower in the specimens without an oxygen-inhibited layer. The oxygen-inhibited layer therefore appeared to promote higher enamel bond strength. 相似文献
62.
Kenji Ishido Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Tohru Sasaki Chikatoshi Katada Shouko Komori Kazushige Hayakawa Kei Hosoda Keishi Yamashita Natsuya Katada Wasaburo Koizumi 《Japanese journal of radiology》2016,34(1):35-42
Objectives
Whether chemoradiotherapy (CRT) is clinically beneficial for the management of postoperative recurrence of advanced gastric cancer remains unclear. We retrospectively studied treatment outcomes in patients who had unresectable localized recurrence after surgery for advanced gastric cancer and evaluated the safety and efficacy of CRT.Methods
The study group comprised 21 patients who received concurrent CRT for unresectable localized recurrence after undergoing R0 resection for stage II/III advanced gastric cancer. Localized recurrence was defined as a few or limited recurrent lesions.Results
The recurrence pattern was anastomotic recurrence in 7 patients, abdominal lymph-node recurrence in 12, and anastomotic recurrence plus abdominal lymph-node recurrence in 2. The median total dose of radiotherapy was 48.6 Gy (range 39.6–56.0), and the CRT completion rate was 100 % (21 of 21 patients). CRT-related grade 3 or higher toxicity comprised neutropenia in 33.3 % of patients and anorexia in 9.5 %. The response rate was 61.9 % (complete response 38.1 %, partial response 23.8 %). The median overall survival was 35.0 months.Conclusions
We conclude that CRT may become one treatment strategy for the management of unresectable localized recurrence after curative resection of advanced gastric cancer.63.
64.
Factors affecting N‐terminal pro‐brain natriuretic peptide elevation in the acute phase of Kawasaki disease 下载免费PDF全文
65.
66.
Uptake and intracellular activity of NM394, a new quinolone, in human polymorphonuclear leukocytes. 总被引:3,自引:0,他引:3 下载免费PDF全文
M Ozaki K Komori M Matsuda R Yamaguchi T Honmura Y Tomii I Nishimura T Nishino 《Antimicrobial agents and chemotherapy》1996,40(3):739-742
The uptake of NM394, a new quinolone, by and its subsequent elution from human polymorphonuclear leukocytes were studied and compared with those of ofloxacin and ciprofloxacin. The kinetics of the uptake of NM394 was similar to that of ciprofloxacin. The maximum intracellular-to-extracellular concentration ratio was 12.3, compared with 8.6 for ciprofloxacin and 4.9 for ofloxacin at the extracellular concentration of 20 micrograms/ml. The elution of NM394 from human polymorphonuclear leukocytes occurs relatively slowly; 5 min after the removal of extracellular NM394, nearly 100% still remained in polymorphonuclear leukocytes, compared with ofloxacin, which was so rapidly eluted that only 12% remained. The uptake of NM394 was significantly decreased at 4 degrees C and by the presence of NaCN but was not affected by the presence of L-glycine, L-leucine, L-serine, adenosine, or NaF. NM394 showed intracellular activity at a concentration of 0.1 microgram/ml that significantly reduced the number of phagocytosed Pseudomonas aeruginosa cells with 2 h of incubation. These results suggest that uptake of NM394 by human polymorphonuclear leukocytes occurs via an active transport system differing from that of ofloxacin, whose uptake is affected by the presence of L-glycine and L-leucine, and that once accumulated, NM394 remains intracellularly active and participates in protection against bacterial infection. 相似文献
67.
Mitsuru Saito Yoshikuni Kida Soki Kato Keishi Marumo 《Current osteoporosis reports》2014,12(2):181-188
Diabetes increases risk of fracture, although type 2 diabetes is characterized by normal or high bone mineral density (BMD) compared with the patients without diabetes. The fracture risk of type 1 diabetes as well as type 2 diabetes increases beyond an explained by a decrease of BMD. Thus, diabetes may reduce bone strength without change in BMD. Whole bone strength is determined by bone density, structure, and quality, which encompass the micro-structural and tissue material properties. Recent literature showed that diabetes reduces bone material properties rather than BMD. Collagen intermolecular cross-linking plays an important role in the expression of bone strength. Collagen cross-links can be divided into beneficial enzymatic immature divalent and mature trivalent cross-links and disadvantageous nonenzymatic cross-links (Advanced glycation end products: AGEs) induced by glycation and oxidation. The formation pathway and biological function are quite different. Not only hyperglycemia, but also oxidative stress induces the reduction in enzymatic cross-links and the formation of AGEs. In this review, we describe the mechanism of low bone quality in diabetes and the usefulness of the measurement of plasma or urinary level of AGEs for estimation of fracture risk. 相似文献
68.
69.
Kazuo Tsunoda M.D. Ph.D. Keishi Abe Ken Omata Takeshi Hagino Naoyoshi Minami Masanori Munakata Kazunori Yoshida Hiromichi Sakuma Seiichi Misawa Syuuji Arima Yutaka Imai Kaoru Yoshinaga 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》1993,7(2):253-256
Summary The effects of cicletanine, a new antihypertensive agent, on the prostaglandin-kallikrein system and the reninangiotensin system were studied. A single oral dose of 200 mg cicletanine or placebo was administered to 9 healthy male volunteers, with samples of blood and urine obtained before and 2 hours after drug administration. Cicletanine increased the urine flow, urinary excretion of sodium, and fractional excretion of sodium by 47%, 115%, and 104%, respectively. While the excretion of 6-keto-prostaglandin-F1 was enhanced significantly, urinary excretion of thromboxane-B2, prostaglandin-E2, and kallikrein were unchanged. Cicletanine also did not alter plasma renin activity, plasma aldosterone concentration, or creatinine clearance. These observations suggest that cicletanine may suppress sodium reabsorption at the nephron, and it may stimulate prostacyclin generation with no effect on that of thromboxane-A2. Thus cicletanine may be beneficial in the management of cardiovascular disorders in which the equilibrium between prostacyclin and thromboxane is disturbed. 相似文献
70.
Hisato Nakazawa Masataka Komori Yuta Shibamoto Takahiko Tsugawa Yoshimasa Mori Tatsuya Kobayashi 《Acta neurochirurgica》2014,156(8):1483-1489