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971.
972.
Tohi Yoichiro Kato Takuma Fukuhara Hideo Kobayashi Keita Ohira Shin Ikeda Kenichiro Daizumoto Kei Katayama Satoshi Shimizu Ryutaro Nishimura Kenichi Nagami Taichi Hayashida Yushi Hirama Hiromi Takamoto Atsushi Dainichi Teruki Sugimoto Mikio 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(8):1348-1355
International Journal of Clinical Oncology - Apalutamide-associated skin adverse events are more common in the Japanese than in the global population. However, limited clinical data have hampered... 相似文献
973.
Niu John Yun Yin Iris Xiaoxue Wu William Ka Kei Li Quan-Li Mei May Lei Chu Chun Hung 《Clinical oral investigations》2022,26(3):2441-2451
Clinical Oral Investigations - To investigate the antibiofilm and remineralising effects of the dual-action peptide GA-KR12 on artificial enamel caries. Enamel blocks with artificial caries were... 相似文献
974.
975.
Outdoor air pollution has been recently classified as a class I human carcinogen by the World Health Organization (WHO). Cumulative evidence from across the globe shows that polluted air is associated with increased risk of lung, head and neck, and nasopharyngeal cancers--all of which affect the upper aerodigestive tract. Importantly, these cancers have been previously linked to smoking. In this article, we review epidemiologic and experimental evidence of the genotoxic and mutagenic effects of air pollution on DNA, purportedly a key mechanism for cancer development. The alarming increase in cancers of the upper aerodigestive tract in Asia suggests a need to focus government efforts and research on reducing air pollution, promoting clean energy, and investigating the carcinogenic effects of air pollution on humans. 相似文献
976.
Tolerance of organs at risk in small-volume,hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers 总被引:10,自引:0,他引:10
Onimaru R Shirato H Shimizu S Kitamura K Xu B Fukumoto S Chang TC Fujita K Oita M Miyasaka K Nishimura M Dosaka-Akita H 《International journal of radiation oncology, biology, physics》2003,56(1):126-135
PURPOSE: To determine the organ at risk and the maximum tolerated dose (MTD) of radiation that could be delivered to lung cancer using small-volume, image-guided radiotherapy (IGRT) using hypofractionated, coplanar, and noncoplanar multiple fields. MATERIALS AND METHODS: Patients with measurable lung cancer (except small-cell lung cancer) 6 cm or less in diameter for whom surgery was not indicated were eligible for this study. Internal target volume was determined using averaged CT under normal breathing, and for patients with large respiratory motion, using two additional CT scans with breath-holding at the expiratory and inspiratory phases in the same table position. Patients were localized at the isocenter after three-dimensional treatment planning. Their setup was corrected by comparing two linacographies that were orthogonal at the isocenter with corresponding digitally reconstructed images. Megavoltage X-rays using noncoplanar multiple static ports or arcs were used to cover the parenchymal tumor mass. Prophylactic nodal irradiation was not performed. The radiation dose was started at 60 Gy in 8 fractions over 2 weeks (60 Gy/8 Fr/2 weeks) for peripheral lesions 3.0 cm or less, and at 48 Gy/8 Fr/2 weeks at the isocenter for central lesions or tumors more than 3.0 cm at their greatest dimension. RESULTS: Fifty-seven lesions in 45 patients were treated. Tumor size ranged from 0.6 to 6.0 cm, with a median of 2.6 cm. Using the starting dose, 1 patient with a central lesion died of a radiation-induced ulcer in the esophagus after receiving 48 Gy/8 Fr at isocenter. Although the contour of esophagus received 80% or less of the prescribed dose in the planning, recontouring of esophagus in retrospective review revealed that 1 cc of esophagus might have received 42.5 Gy, with the maximum dose of 50.5 Gy. One patient with a peripheral lesion experienced Grade 2 pain at the internal chest wall or visceral pleura after receiving 54 Gy/8 Fr. No adverse respiratory reaction was noted in the symptoms or respiratory function tests. The 3-year local control rate was 80.4% +/- 7.1% (a standard error) with a median follow-up period of 17 months for survivors. Because of the Grade 5 toxicity, we have halted this Phase I/II study and are planning to rearrange the protocol setting accordingly. The 3-year local control rate was 69.6 +/- 10.6% for patients who received 48 Gy and 100% for patients who received 60 Gy (p = 0.0442). CONCLUSIONS: Small-volume IGRT using 60 Gy in eight fractions is highly effective for the local control of lung tumors, but MTD has not been determined in this study. The organs at risk are extrapleural organs such as the esophagus and internal chest wall/visceral pleura rather than the pulmonary parenchyma in the present protocol setting. Consideration of the uncertainty in the contouring of normal structures is critically important, as is uncertainty in setup of patients and internal organ in the high-dose hypofractionated IGRT. 相似文献
977.
Nobuhiro Asai Masahiro Aoshima Yoshihiro Ohkuni Haruki Kobayashi Ryo Matsunuma Kei Nakashima Naoko Katsurada Norihiro Kaneko Hiroto Nakano Kazuo Matsui Yoshihito Otsuka Yasutaka Kawamura 《Journal of infection and chemotherapy》2012,18(6):965-969
Pneumocystis pneumonia (PCP) can occur in patients with many causes of the immunocompromised state other than human immunodeficiency virus (HIV). It is quite difficult to diagnose PCP without HIV because there is no method for detecting Pneumocystis jirovecii. Thus, non-HIV PCP continues to have high mortality. Recently, loop-mediated isothermal amplification (LAMP) is becoming an established nucleic acid amplification method offering rapid, accurate, and cost-effective diagnosis of infectious diseases. We report a non-HIV PCP case successfully diagnosed by the LAMP method. It was previously reported that PCR in BALF specimens had been the most sensitive method in the diagnosis of PCP without HIV. The LAMP method would be more sensitive than conventional PCR and an effective tool in the early diagnosis of PCP. 相似文献
978.
Shigeyoshi Kijima Kiyoka Omoto Kenichi Utano Atsuko Sakamoto Hiroaki Matsunaga Harumi Koibuchi Yasutomo Fujii Nobuyuki Taniguchi Kei Konno Hideharu Sugimoto 《Journal of Medical Ultrasonics》2012,39(1):29-31
Sister Mary Joseph’s nodule (SMJN), which is known as a malignant tumor metastasized to the umbilicus, is a rare condition.
We report ultrasonic findings of SMJN secondary to ovarian cancer in a 66-year-old woman. The umbilical tumor was observed
as a hypoechoic mass with punctate hyperechoic foci. A pathological specimen obtained by needle biopsy confirmed adenocarcinoma
with psammoma bodies. A comparison of the ultrasonographic findings with the pathological findings of the resected specimen
suggested that the hyperechoic foci corresponded to psammoma bodies. When hyperechoic foci are observed inside SMJN by ultrasonography,
adenocarcinoma from ovarian cancer should be included in the differential diagnosis. 相似文献
979.
980.