全文获取类型
收费全文 | 13219篇 |
免费 | 855篇 |
国内免费 | 227篇 |
专业分类
耳鼻咽喉 | 232篇 |
儿科学 | 114篇 |
妇产科学 | 137篇 |
基础医学 | 2329篇 |
口腔科学 | 213篇 |
临床医学 | 1133篇 |
内科学 | 3085篇 |
皮肤病学 | 599篇 |
神经病学 | 1048篇 |
特种医学 | 585篇 |
外科学 | 1590篇 |
综合类 | 113篇 |
现状与发展 | 1篇 |
预防医学 | 547篇 |
眼科学 | 307篇 |
药学 | 1158篇 |
中国医学 | 190篇 |
肿瘤学 | 920篇 |
出版年
2024年 | 12篇 |
2023年 | 118篇 |
2022年 | 376篇 |
2021年 | 587篇 |
2020年 | 273篇 |
2019年 | 378篇 |
2018年 | 441篇 |
2017年 | 335篇 |
2016年 | 494篇 |
2015年 | 641篇 |
2014年 | 772篇 |
2013年 | 837篇 |
2012年 | 1382篇 |
2011年 | 1278篇 |
2010年 | 698篇 |
2009年 | 595篇 |
2008年 | 781篇 |
2007年 | 738篇 |
2006年 | 598篇 |
2005年 | 589篇 |
2004年 | 436篇 |
2003年 | 408篇 |
2002年 | 350篇 |
2001年 | 233篇 |
2000年 | 216篇 |
1999年 | 169篇 |
1998年 | 81篇 |
1997年 | 65篇 |
1996年 | 36篇 |
1995年 | 34篇 |
1994年 | 35篇 |
1993年 | 26篇 |
1992年 | 47篇 |
1991年 | 29篇 |
1990年 | 36篇 |
1989年 | 25篇 |
1988年 | 24篇 |
1987年 | 11篇 |
1986年 | 13篇 |
1985年 | 16篇 |
1984年 | 11篇 |
1983年 | 12篇 |
1981年 | 4篇 |
1980年 | 5篇 |
1979年 | 7篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1974年 | 4篇 |
1971年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
131.
Soojin Kim Seong-Wook Kim Mai Anh Thi Bui Yeji Kim Minsoo Kim Jung-Cheol Park Nam-Heon Kim Gyeong Hee Pyeon Yong Sang Jo Jaewon Jang Hae-Young Koh Chae-Hong Jeong Moonkyung Kang Hyo Jung Kang Yong-Woo Lee Craig A. Stockmeier Je Kyung Seong Dong Ho Woo Jung-Soo Han Yeon-Soo Kim 《Proceedings of the National Academy of Sciences of the United States of America》2022,119(51)
132.
133.
PurposeThis study evaluated the effect of the excision of redundant skin and pretarsal orbicularis muscle, without vertical or horizontal tarsal fixation, on the correction of involutional entropion.MethodsThis retrospective interventional case series recruited patients with involutional entropion who underwent excision of redundant skin and pretarsal orbicularis muscle, without vertical or horizontal tarsal fixation, from May 2018 to December 2021. Preoperative clinical characteristics and surgical outcomes, including recurrence at 1, 3, and 6 months, were determined by reviewing the medical charts. Surgical treatment included the excision of redundant skin and pretarsal orbicularis muscle, without any tarsal fixation, and simple skin suture.ResultsAll 52 patients (58 eyelids) attended every follow-up visit and were thus included in the analysis. Among 58 eyelids, 55 (94.8%) had satisfactory results. The recurrence rate was 3.45% (two eyelids) and the overcorrection rate was 1.7% (one eyelid).ConclusionsExcision of only redundant skin and the pretarsal orbicularis muscle, without capsulopalpebral fascia reattachment or horizontal lid laxity correction, is a simple surgery for correcting involutional entropion. 相似文献
134.
Hwe Hoon Chung Seung Hee Seo Hyemin Kim Yuil Kim Dong Wuk Kim Kwang Hyuck Lee Kyu Taek Lee Jin Seok Heo In Woong Han Seon Mee Park Kee-Taek Jang Jong Kyun Lee Joo Kyung Park 《Gut and liver》2023,17(1):159
Background/AimsCholangiocarcinoma frequently recurs even after curative resection. Expression levels of proteins such as epidermal growth factor receptor (EGFR), Snail, epithelial cadherin (E-cadherin), and interleukin-6 (IL-6) examined by immunohistochemistry have been studied as potential prognostic factors for cholangiocarcinoma. The aim of this study was to investigate significant factors affecting the prognosis of resectable cholangiocarcinoma.MethodsNinety-one patients who underwent surgical resection at Samsung Medical Center for cholangiocarcinoma from 1995 to 2013 were included in this study. Expression levels of E-cadherin, Snail, IL-6, membranous EGFR, and cytoplasmic EGFR were analyzed by immunohistochemistry using tissue microarray blocks made from surgical specimens.ResultsPatients with high levels of membranous EGFR in tissue microarrays had significantly shorter overall survival (OS) and disease-free survival (DFS) high membranous EGFR (score 0–2) 38.0 months versus low membranous EGFR (score 3) 14.4 months (p=0.008) and high membranous EGFR (score 0–2) 23.2 months versus low membranous EGFR (score 3) 6.1 months (p=0.004), respectively. On the other hand, E-cadherin, Snail, cytoplasmic EGFR, and IL-6 did not show significant association with OS or DFS. Patients with distant metastasis had significantly higher IL-6 levels than those with locoregional recurrence (p=0.01).ConclusionsThis study showed that overexpression of membranous EGFR was significantly associated with shorter OS and DFS in surgically resected bile duct cancer patients. In addition, higher IL-6 expression was a predictive marker for recurrence in cholangiocarcinoma patients with distant organ metastasis after surgical resection. 相似文献
135.
Wolhwa Song Sung Hwan Yoo Jinsun Jang Su Jung Baik Byoung Kwon Lee Hyun Woong Lee Jong Suk Park 《Gut and liver》2023,17(1):130
Background/AimsThere are no data regarding the association between sarcopenic obesity status and nonalcoholic fatty liver disease (NAFLD) and NAFLD-associated liver fibrosis. Therefore, we aimed to investigate the relationship between sarcopenic obesity status (sarcopenia only, obesity only, and sarcopenic obesity) and NAFLD and liver fibrosis in Korean adults.MethodsIn total, 2,191 subjects completed a health checkup program, including abdominal ultrasonography and FibroScan. Subjects were classified into the following four categories optimal body composition (nonobese and nonsarcopenic), sarcopenia only (nonobese), obesity only (nonsarcopenic), and sarcopenic obesity. Sarcopenic obesity was stratified by the skeletal muscle mass index and body fat using bioelectrical impedance analysis. NAFLD was diagnosed by ultrasonography, and liver fibrosis was assessed using transient elastography in subjects with NAFLD.ResultsThe prevalence of NAFLD and liver fibrosis significantly increased according to the sarcopenic obesity status. In the logistic regression analysis, after adjusting for multiple risk factors, the odds ratio (OR) for the risk of NAFLD was largest in the sarcopenic obesity group (OR, 3.68; 95% confidence interval [CI], 2.94 to 4.60), followed by the obesity only (OR, 2.25; 95% CI, 1.67 to 3.03) and sarcopenia only (OR, 1.92; 95% CI, 1.30 to 2.84) groups, when compared with the optimal group. Additionally, liver fibrosis was independently associated with sarcopenic obesity status (OR 4.69, 95% CI 1.95 to 11.29; OR 4.17, 95% CI 1.56 to 11.17; OR 3.80, 95% CI 0.86 to 16.75, respectively).ConclusionsThese results demonstrated that sarcopenic obesity was independently associated with NAFLD and liver fibrosis and increased the risk of NAFLD and liver fibrosis more than obesity or sarcopenia alone. 相似文献
136.
137.
138.
Bei Liu Sae Hoon Kim Young Hoon Jang Sung-Min Rhee Jae Chul Yoo Su Cheol Kim Yong Girl Rhee Joo Han Oh 《Clinics in Orthopedic Surgery》2023,15(1):118
BackgroundSynovial osteochondromatosis (SOC) of the shoulder is a rare condition with unclear characteristics. This study evaluated the clinical features and postoperative functional outcomes of SOC of the shoulder that are distinct from SOC of other joints.MethodsThe characteristics of 28 shoulders with SOC that underwent arthroscopy were retrospectively assessed. Ten shoulders (35.7%) had rotator cuff tears (RCTs) and underwent concomitant arthroscopic rotator cuff repair. The mean follow-up period was 83.6 months (range, 24–154 months). Demographic characteristics and loose bodies localized under arthroscopy were compared between cases with and without concomitant RCTs. Radiography, ultrasonography, or magnetic resonance imaging were performed preoperatively and postoperatively. Visual analog scale (VAS) scores for pain and satisfaction were evaluated for all cases, and functional scores were assessed in shoulders with concomitant RCTs.ResultsThe average age was 36.2 ± 15.6 years among patients without RCTs and 58.3 ± 7.2 years among patients with RCTs. Seven shoulders (7%) had osteoarthritis. Arthroscopy revealed loose bodies in multiple spaces, including the glenohumeral joint, subacromial (SA) space, and biceps tendon sheath. Overall, loose bodies were found in multiple spaces in 12 shoulders (42.9%). Loose bodies were found in the SA space only in 4 shoulders (22.2%) without RCTs and in 7 shoulders (70.0%) with RCTs. VAS for pain decreased significantly from 3.9 ± 2.3 to 1.1 ± 1.3 (p < 0.001). The functional scores increased significantly after arthroscopic management for patients with concurrent RCTs (all p < 0.05). Recurrence of SOC occurred in 3 of the 22 shoulders (13.6%) who underwent postoperative imaging, but no patient had a recurrent RCT.ConclusionsPain relief and patient satisfaction were achieved via arthroscopic management. Unlike in other joints, loose bodies can occur simultaneously in several spaces in the shoulder, including the glenohumeral joint, SA space, and biceps tendon sheath. Early diagnosis of SOC of the SA space can help prevent osteoarthritis and RCT progression. 相似文献
139.
Jung-Won Choi Kee Ook Lee Ye-Ji Jang Hyun-Kyung Kim Taeho Seo Yoo Jeong Roh Seung-Ook Choo Seung-Hun Oh 《Yonsei medical journal》2023,64(1):35
PurposeThe mean platelet volume (MPV) is regarded as a marker for thrombosis, atherosclerosis, and inflammation in various vascular diseases. However, it still remains unclear whether plasma MPV is associated with cerebral white matter hyperintensities (WMH) and cerebral microvascular pathology in the elderly population.Materials and MethodsWe examined whether MPV level is associated with the presence of cerebral WMH on brain magnetic resonance imaging from 870 non-stroke outpatient subjects. The subjects were divided into three groups according to the consecutive level of MPV (low T1, middle T2, and high T3 MPV tertile groups). To determine the association of MPV levels with the WMH, logistic regression and receiver operating characteristic curve analyses were conducted.ResultsSubjects with higher MPV level were older and more likely to have hypertension, diabetes mellitus, and low renal function. Cerebral WMH were more prevalent in subjects with higher MPV level. After adjusting for confounding factors, moderate to severe cerebral WMH were significantly associated with high MPV tertile level. This association remained significant after adjusting for other cerebral vascular pathologies. T2 [odds ratio (OR): 1.49, 95% confidence interval (CI): 1.03–2.15] and T3 MPV tertile groups (OR: 1.51, 95%CI: 1.04–2.20) had more cerebral WMH lesions compared to T1 MPV tertile group. In addition, the subjects with higher Fazekas scores showed higher MPV level (p=0.020).ConclusionWe found that high MPV level is independently associated with cerebral WMH. This result suggests that platelet activation plays a role in the development of cerebral WMH. 相似文献
140.
Joo Myung Lee Hyun Sung Joh Ki Hong Choi David Hong Taek Kyu Park Jeong Hoon Yang Young Bin Song Jin-Ho Choi Seung-Hyuk Choi Jin-Ok Jeong Jong-Young Lee Young Jin Choi Jei-Keon Chae Seung-Ho Hur Jang-Whan Bae Ju-Hyeon Oh Kook-Jin Chun Hyun-Joong Kim Byung Ryul Cho Doosup Shin Seung Hun Lee Doyeon Hwang Hyun-Jong Lee Ho-Jun Jang Hyun Kuk Kim Sang Jin Ha Eun-Seok Shin Joon-Hyung Doh Joo-Yong Hahn Hyeon-Cheol Gwon 《Journal of Korean medical science》2023,38(5)
BackgroundThe risk of device thrombosis and device-oriented clinical outcomes with bioresorbable vascular scaffold (BVS) was reported to be significantly higher than with contemporary drug-eluting stents (DESs). However, optimal device implantation may improve clinical outcomes in patients receiving BVS. The current study evaluated mid-term safety and efficacy of Absorb BVS with meticulous device optimization under intravascular imaging guidance.MethodsThe SMART-REWARD and PERSPECTIVE-PCI registries in Korea prospectively enrolled 390 patients with BVS and 675 patients with DES, respectively. The primary endpoint was target vessel failure (TVF) at 2 years and the secondary major endpoint was patient-oriented composite outcome (POCO) at 2 years.ResultsPatient-level pooled analysis evaluated 1,003 patients (377 patients with BVS and 626 patients with DES). Mean scaffold diameter per lesion was 3.24 ± 0.30 mm in BVS group. Most BVSs were implanted with pre-dilatation (90.9%), intravascular imaging guidance (74.9%), and post-dilatation (73.1%) at proximal to mid segment (81.9%) in target vessel. Patients treated with BVS showed comparable risks of 2-year TVF (2.9% vs. 3.7%, adjusted hazard ratio [HR], 1.283, 95% confidence interval [CI], 0.487–3.378, P = 0.615) and 2-year POCO (4.5% vs. 5.9%, adjusted HR, 1.413, 95% CI, 0.663–3.012, P = 0.370) than those with DES. The rate of 2-year definite or probable device thrombosis (0.3% vs. 0.5%, P = 0.424) was also similar. The sensitivity analyses consistently showed comparable risk of TVF and POCO between the 2 groups.ConclusionWith meticulous device optimization under imaging guidance and avoidance of implantation in small vessels, BVS showed comparable risks of 2-year TVF and device thrombosis with DES.Trial RegistrationClinicalTrials.gov Identifier: , NCT02601404 NCT04265443相似文献